24,210 research outputs found
Diffractive charged meson pair production
We investigate the possibility to measure the nonforward gluon distribution
function by means of diffractively produced \pi^+\pi^- and K^+K^- pairs in
polarized lepton nucleon scattering. The resulting cross sections are small and
are dominated by the gluonic contribution. We find relatively large spin
asymmetries, both for \pi^+\pi^- and for K^+K^- pairs.Comment: 15 pages, version with changed kinematical cuts, to be pubished in
Phys.Lett.
Observational manifestations of solar magneto-convection -- center-to-limb variation
We present the first center-to-limb G-band images synthesized from high
resolution simulations of solar magneto-convection. Towards the limb the
simulations show "hilly" granulation with dark bands on the far side, bright
granulation walls and striated faculae, similar to observations. At disk center
G-band bright points are flanked by dark lanes. The increased brightness in
magnetic elements is due to their lower density compared with the surrounding
intergranular medium. One thus sees deeper layers where the temperature is
higher. At a given geometric height, the magnetic elements are cooler than the
surrounding medium. In the G-band, the contrast is further increased by the
destruction of CH in the low density magnetic elements. The optical depth unity
surface is very corrugated. Bright granules have their continuum optical depth
unity 80 km above the mean surface, the magnetic elements 200-300 km below. The
horizontal temperature gradient is especially large next to flux
concentrations. When viewed at an angle, the deep magnetic elements optical
surface is hidden by the granules and the bright points are no longer visible,
except where the "magnetic valleys" are aligned with the line of sight. Towards
the limb, the low density in the strong magnetic elements causes unit
line-of-sight optical depth to occur deeper in the granule walls behind than
for rays not going through magnetic elements and variations in the field
strength produce a striated appearance in the bright granule walls.Comment: To appear in ApJL. 6 pages 4 figure
Development of Protacs to Target Cancer-promoting Proteins for Ubiquitination and Degradation
The proteome contains hundreds of proteins that in theory could be excellent therapeutic targets for the treatment of human diseases. However, many of these proteins are from functional classes that have never been validated as viable candidates for the development of small molecule inhibitors. Thus, to exploit fully the potential of the Human Genome Project to advance human medicine, there is a need to develop generic methods of inhibiting protein activity that do not rely on the target proteinâs function. We previously demonstrated that a normally stable protein, methionine aminopeptidase-2 or MetAP-2, could be artificially targeted to an Skp1-Cullin-F-box (SCF) ubiquitin ligase complex for ubiquitination and degradation through a chimeric bridging molecule or Protac (proteolysis targeting chimeric molecule). This Protac consisted of an SCFĂ-TRCP-binding phosphopeptide derived from I{kappa}B{alpha} linked to ovalicin, which covalently binds MetAP-2. In this study, we employed this approach to target two different proteins, the estrogen (ER) and androgen (AR) receptors, which have been implicated in the progression of breast and prostate cancer, respectively. We show here that an estradiol-based Protac can enforce the ubiquitination and degradation of the {alpha} isoform of ER in vitro, and a dihydroxytestosterone-based Protac introduced into cells promotes the rapid disappearance of AR in a proteasome-dependent manner. Future improvements to this technology may yield a general approach to treat a number of human diseases, including cancer
Research review: young people leaving care
This paper reviews the international research on young people leaving care. Set in the context of a social exclusion framework, it explores young people's accelerated and compressed transitions to adulthood, and discusses the development and classification of leaving care services in responding to their needs. It then considers the evidence from outcome studies and argues that adopting a resilience framework suggests that young people leaving care may fall into three groups: young people 'moving on', 'survivors' and 'victims'. In concluding, it argues that these three pathways are associated with the quality of care young people receive, their transitions from care and the support they receive after care
Solar Oscillations and Convection: II. Excitation of Radial Oscillations
Solar p-mode oscillations are excited by the work of stochastic,
non-adiabatic, pressure fluctuations on the compressive modes. We evaluate the
expression for the radial mode excitation rate derived by Nordlund and Stein
(Paper I) using numerical simulations of near surface solar convection. We
first apply this expression to the three radial modes of the simulation and
obtain good agreement between the predicted excitation rate and the actual mode
damping rates as determined from their energies and the widths of their
resolved spectral profiles. We then apply this expression for the mode
excitation rate to the solar modes and obtain excellent agreement with the low
l damping rates determined from GOLF data. Excitation occurs close to the
surface, mainly in the intergranular lanes and near the boundaries of granules
(where turbulence and radiative cooling are large). The non-adiabatic pressure
fluctuations near the surface are produced by small instantaneous local
imbalances between the divergence of the radiative and convective fluxes near
the solar surface. Below the surface, the non-adiabatic pressure fluctuations
are produced primarily by turbulent pressure fluctuations (Reynolds stresses).
The frequency dependence of the mode excitation is due to effects of the mode
structure and the pressure fluctuation spectrum. Excitation is small at low
frequencies due to mode properties -- the mode compression decreases and the
mode mass increases at low frequency. Excitation is small at high frequencies
due to the pressure fluctuation spectrum -- pressure fluctuations become small
at high frequencies because they are due to convection which is a long time
scale phenomena compared to the dominant p-mode periods.Comment: Accepted for publication in ApJ (scheduled for Dec 10, 2000 issue).
17 pages, 27 figures, some with reduced resolution -- high resolution
versions available at http://www.astro.ku.dk/~aake/astro-ph/0008048
Effect of Intermolecular Interactions between CH Frequencies on the Infrared Spectra of NâParaffins and Polythene
A systematic study has been made of the infrared absorption band near 725 cmâ1 which arises from the rocking vibration of methylene groups in nâparaffins and in polyethylene. In unoriented crystals of nâparaffins, this band exhibits two components of equal intensity below the transition point; above the transition temperature and in the liquid state only the higher frequency component is found. In solid coldâdrawn polyethylene the two components are of unequal intensity, the low frequency component being the stronger; in liquid polyethylene only the lower frequency component is found. Studies were made of polyethylene in various states of crystallinity and orientation, using both polarized and unpolarized radiation. The results obtained can be consistently interpreted, if the higher frequency component is attributed to crystallites in the polyethylene and the lower frequency component is assumed to be due partly to the crystalline and partly to the amorphous form of the polyethylene. It is concluded that the doubling of this frequency arises from some interaction between methylene groups which is peculiar to the crystalline state of long chain nâparaffins below their transition points.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/69988/2/JCPSA6-22-12-1993-1.pd
Making a home, finding a job: investigating early housing and employment outcomes for young people leaving care
This paper presents findings from a new study of outcomes for young people leaving care funded by the Department for Education and Skills. It reports findings for a sample of 106 young people in relation to progress made in housing and employment some 12-15 months after leaving care. The generally poor employment outcomes of care leavers are acknowledged, but ingredients that make for success are also highlighted, including the value of settled care and post-care careers, sound career planning and, significantly, the value of delaying young people's transitions from care. Early career paths also interconnect with how young people fare in housing, in developing life skills and with other problems in their lives after leaving care. Housing outcomes were more encouraging and predominantly shaped by events after leaving care, and faring well in housing was the factor most closely associated with positive mental well-being in young people. Some groups that are at risk of faring badly are identified, including young people with mental-health problems, young people with persistent offending or substance misuse problems and, in some respects, young disabled people. The implications of these findings for leaving care services are considered
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