Forbidden ordinal patterns in higher dimensional dynamics

Forbidden ordinal patterns are ordinal patterns (or `rank blocks') that cannot appear in the orbits generated by a map taking values on a linearly ordered space, in which case we say that the map has forbidden patterns. Once a map has a forbidden pattern of a given length $L_{0}$, it has forbidden patterns of any length $L\ge L_{0}$ and their number grows superexponentially with $L$. Using recent results on topological permutation entropy, we study in this paper the existence and some basic properties of forbidden ordinal patterns for self maps on n-dimensional intervals. Our most applicable conclusion is that expansive interval maps with finite topological entropy have necessarily forbidden patterns, although we conjecture that this is also the case under more general conditions. The theoretical results are nicely illustrated for n=2 both using the naive counting estimator for forbidden patterns and Chao's estimator for the number of classes in a population. The robustness of forbidden ordinal patterns against observational white noise is also illustrated.Comment: 19 pages, 6 figure

Anteseden employee performance BPS DKI Jakarta

Tujuan dari penelitian ini adalah untuk menganalisis Anteseden Employee Performance Pada Badan Pusat Statistik DKI Jakarta. Metode analisis data menggunakan metode SEM dengan program AMOS 26. Teknik pengumpulan data adalah survei dengan membagikan kuesioner yang dikembangkan dari peneliti terlebih dahulu. Teknik pengambilan sampel menggunakan purposive sampling dengan jumlah responden 107 orang. dan yang menjadi fokus dari penelitian ini adalah untuk mengetahui besarnya pengaruh antar variabel yang diteliti. Berdasarkan dari hasil penelitian, terdapat pengaruh Work life balance, Reward and Recognition, Artificial Intelligence terhadap Employee Engagement; terdapat pengaruh Employee Engagement terhadap Employee Performance; Employee Engagement memediasi pengaruh Work Life Balance, Artificial Intelligence terhadap Employee Performance. Saran Untuk penelitian selanjutnya disarankan untuk mengambil sampel yang lebih luas dari beberapa kantor Badan Pusat Statistik dari provinsi lainnya di Indonesia sehingga dapat diperoleh gambaran yang lebih komprehensif mengenai variabel-variabel yang diteliti

categoryCompare, an analytical tool based on feature annotations

Assessment of high-throughput—omics data initially focuses on relative or raw levels of a particular feature, such as an expression value for a transcript, protein, or metabolite. At a second level, analyses of annotations including known or predicted functions and associations of each individual feature, attempt to distill biological context. Most currently available comparative- and meta-analyses methods are dependent on the availability of identical features across data sets, and concentrate on determining features that are differentially expressed across experiments, some of which may be considered “biomarkers.” The heterogeneity of measurement platforms and inherent variability of biological systems confounds the search for robust biomarkers indicative of a particular condition. In many instances, however, multiple data sets show involvement of common biological processes or signaling pathways, even though individual features are not commonly measured or differentially expressed between them. We developed a methodology, categoryCompare, for cross-platform and cross-sample comparison of high-throughput data at the annotation level. We assessed the utility of the approach using hypothetical data, as well as determining similarities and differences in the set of processes in two instances: (1) denervated skin vs. denervated muscle, and (2) colon from Crohn's disease vs. colon from ulcerative colitis (UC). The hypothetical data showed that in many cases comparing annotations gave superior results to comparing only at the gene level. Improved analytical results depended as well on the number of genes included in the annotation term, the amount of noise in relation to the number of genes expressing in unenriched annotation categories, and the specific method in which samples are combined. In the skin vs. muscle denervation comparison, the tissues demonstrated markedly different responses. The Crohn's vs. UC comparison showed gross similarities in inflammatory response in the two diseases, with particular processes specific to each disease

Preformulation and stability in biological fluids of the retrocyclin RC-101, a potential anti-HIV topical microbicide

<p>Abstract</p> <p>Background</p> <p>RC-101, a cationic peptide retrocyclin analog, has <it>in vitro </it>activity against HIV-1. Peptide drugs are commonly prone to conformational changes, oxidation and hydrolysis when exposed to excipients in a formulation or biological fluids in the body, this can affect product efficacy. We aimed to investigate RC-101 stability under several conditions including the presence of human vaginal fluids (HVF), enabling the efficient design of a safe and effective microbicide product. Stability studies (temperature, pH, and oxidation) were performed by HPLC, Circular Dichroism, and Mass Spectrometry (LC-MS/MS). Additionally, the effect of HVF on formulated RC-101 was evaluated with fluids collected from healthy volunteers, or from subjects with bacterial vaginosis (BV). RC-101 was monitored by LC-MS/MS for up to 72 h.</p> <p>Results</p> <p>RC-101 was stable at pH 3, 4, and 7, at 25 and 37°C. High concentrations of hydrogen peroxide resulted in less than 10% RC-101 reduction over 24 h. RC-101 was detected 48 h after incubation with normal HVF; however, not following incubation with HVF from BV subjects.</p> <p>Conclusions</p> <p>Our results emphasize the importance of preformulation evaluations and highlight the impact of HVF on microbicide product stability and efficacy. RC-101 was stable in normal HVF for at least 48 h, indicating that it is a promising candidate for microbicide product development. However, RC-101 stability appears compromised in individuals with BV, requiring more advanced formulation strategies for stabilization in this environment.</p

Rapid development of individual identification and presence systems for a critically endangered antelope, the Mountain bongo

Monitoring of species, particularly remnant populations requiring urgent conservation is often hampered by the lack of reliable tools for individual identification (using images or their spoor). Here, we develop rapid monitoring tools for individual animals of the Mountain bongo (Tragelaphus eurycerus isaaci), a critically endangered subspecies of the bongo only found in Kenya. We developed and tested an individual identification system using camera trap footage, as well as a quantitative tool to identify bongo spoor in the field, both useable by naïve observers. We implemented an information content approach to assess the importance of different visual elements in 61 individual bongos to optimise our identification system. We tested the reliability of the system with 15 naïve observers. We conclude that an optimal identification system should rely on three main visual features (stripe pattern, facial markings and horns appearance). We show that reliability amongst observers is high (κ = 0.64). We also developed a field scheme to identify footprint and spoor sign. Measurements of bongo footprints were compared with those of waterbuck (Kobus ellypsiprimnus), a syntopic antelope. Confusion occurs between spoor and footprints of both species. We find that differences in the aspect ratio of bongo and waterbuck footprints can identify the two species, 1.22 (±0.08) for bongo and 1.49 (±0.10) for waterbuck. The acquisition of reliable tools ensures monitoring activities are less dependent on individual expertise, which will allow consistent monitoring of bongo remnant populations in the future. The methods we used to develop these monitoring tools can help managers and field workers in the study of this and similar rare species where monitoring is a challenge

The Color of Childhood: The Role of the Child/Human Binary in the Production of Anti-Black Racism

The binary between the figure of the child and the fully human being is invoked with regularity in analyses of race, yet its centrality to the conception of race has never been fully explored. For most commentators, the figure of the child operates as a metaphoric or rhetorical trope, a non-essential strategic tool in the perpetuation of White supremacy. As I show in the following, the child/human binary does not present a contingent or merely rhetorical construction but, rather, a central feature of racialization. Where Black peoples are situated as objects of violence it is often precisely because Blackness has been identified with childhood and childhood is historically identified as the archetypal site of naturalized violence and servitude. I proceed by offering a historical account of how Black peoples came to inherit the subordination and dehumanization of European childhood and how White youth were subsequently spared through their partial categorization as adults

Inconsistent boundaries

Research on this paper was supported by a grant from the Marsden Fund, Royal Society of New Zealand.Mereotopology is a theory of connected parts. The existence of boundaries, as parts of everyday objects, is basic to any such theory; but in classical mereotopology, there is a problem: if boundaries exist, then either distinct entities cannot be in contact, or else space is not topologically connected (Varzi in Noûs 31:26–58, 1997). In this paper we urge that this problem can be met with a paraconsistent mereotopology, and sketch the details of one such approach. The resulting theory focuses attention on the role of empty parts, in delivering a balanced and bounded metaphysics of naive space.PostprintPeer reviewe