Realisation of an optical pressure standard by a multi-reflection interferometric technique

A novel realization of an optical pressure standard, alternative to Fabry-Perot cavity-based techniques, is presented. It is based on the measurement of the refractive index of a gas through an unbalanced homodyne interferometer, designed to have one of its two arms formed by a multi reflection double mirror assembly to establish an unbalance length larger than 6 m in a compact setup. The paper illustrates the most important steps concerning its realization: the estimate of the pressure-induced deformation of the interferometer, the temperature control at millikelvin level and the measurement in vacuum of the unbalance of the interferometer. The evaluation of the uncertainty of the realized optical pressure standard currently demonstrated to fulfill the main goal of having the ability to measure pressure with a relative uncertainty of 10 ppm at 100 kPa

BESII Detector Simulation

A Monte Carlo program based on Geant3 has been developed for BESII detector simulation. The organization of the program is outlined, and the digitization procedure for simulating the response of various sub-detectors is described. Comparisons with data show that the performance of the program is generally satisfactory.Comment: 17 pages, 14 figures, uses elsart.cls, to be submitted to NIM

Protonium annihilation into π0π0 at rest in a liquid hydrogen target

The annihilation frequency of the reaction p¯ p!p0p0 at rest in liquid hydrogen has been measured by the Obelix experiment by using different apparatus configurations and trigger conditions. The value obtained is f (p0p0, LH)5(2.860.1stat60.4syst)31024. With the same data samples, the p0h annihilation frequency has been determined to be f (p0h, LH)5(0.960.2stat60.1syst)31024. The results are discussed within the frame of the present experimental situation

Global patterns of care in advanced stage mycosis fungoides/Sezary syndrome: a multicenter retrospective follow-up study from the Cutaneous Lymphoma International Consortium

ABSTRACT Background Advanced-stage mycosis fungoides (MF)/Sezary syndrome (SS) patients are weighted by an unfavorable prognosis and share an unmet clinical need of effective treatments. International guidelines are available detailing treatment options for the different stages but without recommending treatments in any particular order due to lack of comparative trials. The aims of this second CLIC study were to retrospectively analyze the pattern of care worldwide for advanced-stage MF/SS patients, the distribution of treatments according to geographical areas (USA versus non-USA), and whether the heterogeneity of approaches has potential impact on survival. Patients and methods This study included 853 patients from 21 specialist centers (14 European, 4 USA, 1 each Australian, Brazilian, and Japanese). Results Heterogeneity of treatment approaches was found, with up to 24 different modalities or combinations used as first-line and 36% of patients receiving four or more treatments. Stage IIB disease was most frequently treated by total-skin-electron-beam radiotherapy, bexarotene and gemcitabine; erythrodermic and SS patients by extracorporeal photochemotherapy, and stage IVA2 by polychemotherapy. Significant differences were found between USA and non-USA centers, with bexarotene, photopheresis and histone deacetylase inhibitors most frequently prescribed for first-line treatment in USA while phototherapy, interferon, chlorambucil and gemcitabine in non-USA centers. These differences did not significantly impact on survival. However, when considering death and therapy change as competing risk events and the impact of first treatment line on both events, both monochemotherapy (SHR = 2.07) and polychemotherapy (SHR = 1.69) showed elevated relative risks. Conclusion This large multicenter retrospective study shows that there exist a large treatment heterogeneity in advanced MF/SS and differences between USA and non-USA centers but these were not related to survival, while our data reveal that chemotherapy as first treatment is associated with a higher risk of death and/or change of therapy and thus other therapeutic options should be preferable as first treatment approach

Facility for the measurement of the refractive index of glass prism

Il manufatto presentato consiste in una stazione di misura dell'indice di rifrazione di prismi in vetro con una incertezza relativa migliore di 1 ppm, allestita all'INRiM nel 2008.A facility for the measurement of glass refractive index with a relative standard uncertainty better than 1 ppm implemented at INRiM in 2008 is presented

The new INRiM nanoangle generator

At the angle metrology laboratory of the Istituto Nazionale di Ricerca Metrologica (INRiM, formerly IMGC), an instrument to generate very small angles has been recently developed. It is a sine-bar angle generator based on an elastic hinge and a piezocapacitive device. The facility can be used to calibrate precise angle measuring instruments (levels, autocollimators, etc) in a range of 120 μrad with an uncertainty of about 20 nrad and a sensitivity of fractions of a nanoradian. The working principle and metrological characterization are presented

Prism refractive index measurement at INRiM

A simple method to measure the refractive index of a glass prism with very low uncertainty was developed at INRiM. The method is a modification of the classical minimum deviation method. A brief description of the methods used to measure the vertex angles of the prism and the angle of minimum deviation is reported together with the uncertainty evaluation. The technique is going to be validated by a comparison between INRiM and two other laboratories. A relative standard uncertainty better than 1 ppm has been obtained

Characterization of 2D angular actuators to the nanoradian level

We present an instrument designed and built to the purpose of characterizing precision angular actuators with a resolution surpassing the best devices on the market. The noise of the device is better than 1 nrad/√Hz in the band from 0.1 Hz to 10 kHz on two orthogonal axes. We synthetically describe the working principle, the practical realization and the case study on a top-level commercial angular actuato