Extension of four-dimensional atmospheric models

The cloud data bank, the 4-D atmospheric model, and a set of computer programs designed to simulate meteorological conditions for any location above the earth are described in turns of space vehicle design and simulation of vehicle reentry trajectories. Topics discussed include: the relationship between satellite and surface observed cloud cover using LANDSAT 1 photographs and including the effects of cloud shadows; extension of the 4-D model to the altitude of 52 km; and addition of the u and v wind components to the 4-D model of means and variances at 1 km levels from the surface to 25 km. Results of the cloud cover analysis are presented along with the stratospheric model and the tropospheric wind profiles

Feline Hypertrophic Cardiomyopathy: A Spontaneous Large Animal Model of Human HCM.

Hypertrophic cardiomyopathy (HCM) is a common disease in pet cats, affecting 10-15% of the pet cat population. The similarity to human HCM, the rapid progression of disease, and the defined and readily determined endpoints of feline HCM make it an excellent natural model that is genotypically and phenotypically similar to human HCM. The Maine Coon and Ragdoll cats are particularly valuable models of HCM because of myosin binding protein-C mutations and even higher disease incidence compared to the overall feline population. The cat overcomes many of the limitations of rodent HCM models, and can provide enhanced translation of information from in vitro and induced small animal models to human clinical trials. Physicians and veterinarians working together in a collaborative and interdisciplinary approach can accelerate the discovery of more effective treatments for this and other cardiovascular diseases affecting human and veterinary patients

Symmetry constraints for the emission angle dependence of Hanbury Brown--Twiss radii

We discuss symmetry constraints on the azimuthal oscillations of two-particle correlation (Hanbury Brown--Twiss interferometry) radii for non-central collisions between equal spherical nuclei. We also propose a new method for correcting in a model-independent way the emission angle dependent correlation function for finite event plane resolution and angular binning effects.Comment: 8 pages revtex4, 2 tables, no figures. Short Section VI added and correction algorithm in Section VII made more explicit. Submitted to Physical Review

The mass-metallicity relation of local active galaxies

We systematically measure the gas-phase metallicities and the mass-metallicity relation of a large sample of local active galaxies for the first time. Observed emission-line fluxes from the Sloan Digital Sky Survey (SDSS) are compared to a four-dimensional grid of photoionization models using the Bayesian parameter estimation code NebulaBayes. For the first time we take into account arbitrary mixing between HII region and narrow-line region (NLR) emission, and the models are also varied with metallicity, ionization parameter in the NLR, and the gas pressure. The active galactic nucleus (AGN) oxygen abundance is found to increase by $\Delta {\rm O/H} \sim 0.1$ dex as a function of host galaxy stellar mass over the range $10.1 < \log M_* / M_\odot < 11.3$. We also measure the metallicity and ionization parameter of 231000 star-forming galaxies for comparison with the sample of 7670 Seyfert 2 galaxies. A systematic offset in oxygen abundance of 0.09 dex is observed between the mass-metallicity relations of the star-forming and active galaxies. We investigate potential causes of the offset, including sample selection and the treatment in the models of diffuse ionized gas, pressure, and ionization parameter. We cannot identify the major cause(s), but suspect contributions due to deficiencies in modeling the ionizing spectra and the treatment of dust physics. Optical diagnostic diagrams are presented with the star-forming and Seyfert data colored by the inferred oxygen abundance, ionization parameter and gas pressure, clearly illustrating the trends in these quantities.Comment: 12 pages, 4 figures and 1 table; accepted for publication in Ap

Self-assembling nanoparticles containing dexamethasone as a novel therapy in allergic airways inflammation.

Nanocarriers can deliver a wide variety of drugs, target them to sites of interest, and protect them from degradation and inactivation by the body. They have the capacity to improve drug action and decrease undesirable systemic effects. We have previously developed a well-defined non-toxic PEG-dendritic block telodendrimer for successful delivery of chemotherapeutics agents and, in these studies, we apply this technology for therapeutic development in asthma. In these proof-of-concept experiments, we hypothesized that dexamethasone contained in self-assembling nanoparticles (Dex-NP) and delivered systemically would target the lung and decrease allergic lung inflammation and airways hyper-responsiveness to a greater degree than equivalent doses of dexamethasone (Dex) alone. We found that ovalbumin (Ova)-exposed mice treated with Dex-NP had significantly fewer total cells (2.78 ± 0.44 × 10(5) (n = 18) vs. 5.98 ± 1.3 × 10(5) (n = 13), P&lt;0.05) and eosinophils (1.09 ± 0.28 × 10(5) (n = 18) vs. 2.94 ± 0.6 × 10(5) (n = 12), p&lt;0.05) in the lung lavage than Ova-exposed mice alone. Also, lower levels of the inflammatory cytokines IL-4 (3.43 ± 1.2 (n = 11) vs. 8.56 ± 2.1 (n = 8) pg/ml, p&lt;0.05) and MCP-1 (13.1 ± 3.6 (n = 8) vs. 28.8 ± 8.7 (n = 10) pg/ml, p&lt;0.05) were found in lungs of the Dex-NP compared to control, and they were not lower in the Dex alone group. In addition, respiratory system resistance was lower in the Dex-NP compared to the other Ova-exposed groups suggesting a better therapeutic effect on airways hyperresponsiveness. Taken together, these findings from early-stage drug development studies suggest that the encapsulation and protection of anti-inflammatory agents such as corticosteroids in nanoparticle formulations can improve efficacy. Further development of novel drugs in nanoparticles is warranted to explore potential treatments for chronic inflammatory diseases such as asthma

XMM-Newton Archival Study of the ULX Population in Nearby Galaxies

We present the results of an archival XMM-Newton study of the bright X-ray point sources (L_X > 10^38 erg/s) in 32 nearby galaxies. From our list of approximately 100 point sources, we attempt to determine if there is a low-state counterpart to the Ultraluminous X-ray (ULX) population, searching for a soft-hard state dichotomy similar to that known for Galactic X-ray binaries and testing the specific predictions of the IMBH hypothesis. To this end, we searched for "low-state" objects, which we defined as objects within our sample which had a spectrum well fit by a simple absorbed power law, and "high-state" objects, which we defined as objects better fit by a combined blackbody and a power law. Assuming that ``low-state'' objects accrete at approximately 10% of the Eddington luminosity (Done & Gierlinski 2003) and that "high-state" objects accrete near the Eddington luminosity we further divided our sample of sources into low and high state ULX sources. We classify 16 sources as low-state ULXs and 26 objects as high-state ULXs. As in Galactic black hole systems, the spectral indices, Gamma, of the low-state objects, as well as the luminosities, tend to be lower than those of the high-state objects. The observed range of blackbody temperatures for the high state is 0.1-1 keV, with the most luminous systems tending toward the lowest temperatures. We therefore divide our high-state ULXs into candidate IMBHs (with blackbody temperatures of approximately 0.1 keV) and candidate stellar mass BHs (with blackbody temperatures of approximately 1.0 keV). A subset of the candidate stellar mass BHs have spectra that are well-fit by a Comptonization model, a property similar of Galactic BHs radiating in the "very-high" state near the Eddington limit.Comment: 54 pages, submitted to ApJ (March 2005), accepted (May 2006); changes to organization of pape

Interrogating Seyferts with NebulaBayes: Spatially probing the narrow-line region radiation fields and chemical abundances

NebulaBayes is a new Bayesian code that implements a general method of comparing observed emission-line fluxes to photoionization model grids. The code enables us to extract robust, spatially resolved measurements of abundances in the extended narrow line regions (ENLRs) produced by Active Galactic Nuclei (AGN). We observe near-constant ionization parameters but steeply radially-declining pressures, which together imply that radiation pressure regulates the ENLR density structure on large scales. Our sample includes four `pure Seyfert' galaxies from the S7 survey that have extensive ENLRs. NGC2992 shows steep metallicity gradients from the nucleus into the ionization cones. An {\it inverse} metallicity gradient is observed in ESO138-G01, which we attribute to a recent gas inflow or minor merger. A uniformly high metallicity and hard ionizing continuum are inferred across the ENLR of Mrk573. Our analysis of IC5063 is likely affected by contamination from shock excitation, which appears to soften the inferred ionizing spectrum. The peak of the ionizing continuum E_peak is determined by the nuclear spectrum and the absorbing column between the nucleus and the ionized nebula. We cannot separate variation in this intrinsic E_peak from the effects of shock or HII region contamination, but E_peak measurements nevertheless give insights into ENLR excitation. We demonstrate the general applicability of NebulaBayes by analyzing a nuclear spectrum from the non-active galaxy NGC4691 using a HII region grid. The NLR and HII region model grids are provided with NebulaBayes for use by the astronomical community.Comment: Accepted for publication in ApJ; 29 pages with 10 figures and 3 table

The H-alpha and Infrared Star Formation Rates for the Nearby Field Galaxy Survey

We investigate the H-alpha and infrared star formation rate (SFR) diagnostics for galaxies in the Nearby Field Galaxy Survey (NFGS). For the 81 galaxies in our sample, we derive H-alpha fluxes (included here) from integrated spectra. There is a strong correlation between the ratio of far-infrared to optical luminosities L(FIR)/L(H-alpha) and the extinction E(B-V) measured with the Balmer decrement. Before reddening correction, the SFR(IR) and SFR(H-alpha) are related to each other by a power-law. Correction of the SFR(H-alpha) for extinction using the Balmer decrement and a classical reddening curve both reduces the scatter in the SFR(IR)-SFR(H-alpha) correlation and results in a much closer agreement (within ~10%) between the two SFR indicators. This SFR relationship spans 4 orders of magnitude and holds for all Hubble types with IRAS detections in the NFGS. A constant ratio between the SFR(IR) and SFR(H-alpha) for all Hubble types, including early types (S0-Sab), suggests that the IR emission in all of these objects results from a young stellar population.Comment: 23 pages, 5 figures, 1 table. Accepted for publication in the Astronomical Journal. V2: Important changes: IRAS fluxes updated. Only moderate and good quality IRAS FIR fluxes are now used, resulting in slight changes to the equations and figures. The IR and H-alpha SFRs now agree to within ~10%, rather than ~30% as quoted previousl

Bifurcated polarization rotation in bismuth-based piezoelectrics

ABO3 perovskite-type solid solutions display a large variety of structural and physical properties, which can be tuned by chemical composition or external parameters such as temperature, pressure, strain, electric, or magnetic fields. Some solid solutions show remarkably enhanced physical properties including colossal magnetoresistance or giant piezoelectricity. It has been recognized that structural distortions, competing on the local level, are key to understanding and tuning these remarkable properties, yet, it remains a challenge to experimentally observe such local structural details. Here, from neutron pair-distribution analysis, a temperature-dependent 3D atomic-level model of the lead-free piezoelectric perovskite Na0.5Bi0.5TiO3 (NBT) is reported. The statistical analysis of this model shows how local distortions compete, how this competition develops with temperature, and, in particular, how different polar displacements of Bi3+ cations coexist as a bifurcated polarization, highlighting the interest of Bi-based materials in the search for new lead-free piezoelectrics