MULTIPACTOR DISCHARGE IN THE ELINAC ACCELERATOR

Abstract This paper concerns numerical simulations and experimental investigation of multipactior discharge in accelerating cavities and the feeding waveguide section of the eLINAC accelerator. The threshold values of the accelerating gradient and of the input power, at which the discharge may occur in these structures, have been obtained experimentally and compared to predictions of numerical simulations. The issues of the influence of secondary emission yield on a discharge growth were also considered

Thermodynamic properties of myo-inositol

© 2017 Elsevier Ltd In the present work, the temperature dependence of heat capacity of vitamin B8 (myo-inositol) has been measured for the first time over the range from 8 K to 340 K by precision adiabatic vacuum calorimetry. Based on the experimental data, the thermodynamic functions of the vitamin B8, namely, the heat capacity, enthalpy H°(T)–H°(0), entropy S°(T)–S°(0) and Gibbs function G°(T)–H°(0) have been determined for the range from T → 0 K to 340 K. The value of the fractal dimension D in the function of multifractal generalization of Debye's theory of the heat capacity of solids was estimated and the character of heterodynamics of structure was detected. The enthalpy of combustion (−2747.0 ± 2.1) kJ·mol−1 of the vitamin B8 was measured for the first time using high-precision combustion calorimeter. The standard molar enthalpy of formation in the crystalline state (−1329.3 ± 2.3) kJ·mol−1 of B8 at 298.15 K was derived from the combustion experiments. Using combination of the adiabatic and combustion calorimetry results the thermodynamic functions of formation of the myo-inositol at T = 298.15 K and p = 0.1 MPa have been calculated. The low-temperature X-ray diffraction was used for the determination of coefficients of thermal expansion

Measurement of electrodynamics characteristics of higher order modes for harmonic cavity at 2400 MHz

In the frameworks of the High Luminosity Large Hadron Collider (HL-LHC) upgrade program an application of additional superconducting harmonic cavities operating at 800 MHz is currently under discussion. As a possible candidate, an assembly of two cavities with grooved beam pipes connected by a drift tube and housed in a common cryomodule, was proposed. In this article we discuss measurements of loaded Q-factors of higher order modes (HOM) performed on a scaled aluminium single cell cavity prototype with the fundamental frequency of 2400 MHz and on an array of two such cavities connected by a narrow beam pipe. The measurements were performed for the system with and without the matching load in the drift tube.

Design, Characteristics and Dynamic Properties of Mobile Plunger based Frequency Tuning System for Coaxial Half Wave Resonators

The practical realization of a prototype of the frequency tuning system FTS for coaxial half wave cavities HWR for the Nuclotron based Ion Collider fAcility NICA in jector is presented. The impact of FTS on electromagnetic parameters of copper HWR prototype is experimentally stud ied and discussed. The most important parameters like tun ing range, tuning sensitivity, the dependence of the resonant frequency on the position of the plungers are estimated. The effective operation algorithms of the proposed FTS are dis cussed and analyzed. The dynamic characteristics of FTS are investigated and showed the ability to adjust the frequency with an accuracy of about 70 H

РЕГУЛИРОВАНИЕ ОТНОШЕНИЙ МЕЖДУ ЗАКАЗЧИКОМ И ИСПОЛНИТЕЛЕМ ГОСУДАРСТВЕННОГО ОБОРОННОГО ЗАКАЗА

Below is the original author's method of assessment of financial and economic sustainability of enterprises-performers of the state defense order. This method takes into account the financial and economic performance of the enterprise. The proposed comprehensive indicator of financial and economic sustainability can be used by the state customer at the stage of analyzing the possibility of the state contract execution by potential contractors.Предложен оригинальный авторский метод оценки финансово-экономической устойчивости предприятий – исполнителей государственного оборонного заказа. Метод учитывает финансовые и экономические показатели деятельности предприятия. Предлагаемый комплексный показатель оценки финансово-экономической устойчивости может быть использован государственным заказчиком на этапе анализа возможностей выполнения государственного контракта потенциальными исполнителями

АНАЛИЗ И ОЦЕНКА РЕЗУЛЬТАТОВ ФИНАНСОВО-ХОЗЯЙСТВЕННОЙ ДЕЯТЕЛЬНОСТИ ДЛЯ МИНИМИЗАЦИИ НАЛОГОВЫХ РИСКОВ ОРГАНИЗАЦИЙ

Below is the original author's approach to the companies' tax risks valuation based on the comparison of the tax and financial statements. Algorithm of the tax risks identification based on the criteria settled by the note of the Federal Tax Authority of Russian Federation from 17.07.2013 №АС-4-2/12722 "About tax authorities committees operation on legalisation of the tax base" is described. Model of the companies classification by tax risks based on the tax burden and specific cash flow is provided.Представлен оригинальный авторский подход к оценке налоговых рисков организаций, который основан на сопоставлении налоговой и бухгалтерской отчетности. Описан алгоритм выявления налоговых рисков по критериям, установленным письмом ФНС РФ от 17.07.2013 г. № АС-4-2/12722 «О работе комиссий налоговых органов по легализации налоговой базы». Представлена модель классификации организаций по налоговым рискам на основе сравнения налоговой нагрузки и удельного денежного потока

Impact of symptoms of eating disorders on the risk of gastrointestinal diseases

The aim of the study - to study the risk of comorbidity of gastrointestinal diseases with eating disordersЦель исследования - изучить влияние симптомов РПП на риск возникновения заболеваний желудочно-кишечного тракта (ЖКТ)

FoxM1 Is a General Target for Proteasome Inhibitors

Proteasome inhibitors are currently in the clinic or in clinical trials, but the mechanism of their anticancer activity is not completely understood. The oncogenic transcription factor FoxM1 is one of the most overexpressed genes in human tumors, while its expression is usually halted in normal non-proliferating cells. Previously, we established that thiazole antibiotics Siomycin A and thiostrepton inhibit FoxM1 and induce apoptosis in human cancer cells. Here, we report that Siomycin A and thiostrepton stabilize the expression of a variety of proteins, such as p21, Mcl-1, p53 and hdm-2 and also act as proteasome inhibitors in vitro. More importantly, we also found that well-known proteasome inhibitors such as MG115, MG132 and bortezomib inhibit FoxM1 transcriptional activity and FoxM1 expression. In addition, overexpression of FoxM1 specifically protects against bortezomib-, but not doxorubicin-induced apoptosis. These data suggest that negative regulation of FoxM1 by proteasome inhibitors is a general feature of these drugs and it may contribute to their anticancer properties

From Barbie to the oligarchs wife: Reading fantasy femininity and globalisation in post-Soviet Russian womens magazines

This article shows how an analysis of fantasy femininity sheds light on how norms of gender, class and national identity reflect global and local cross-cultural currents in post-Soviet Russia. Drawing on a discourse analysis of women’s magazines and in-depth interviews with readers, it shows how, in the globalized post-Soviet cultural landscape, fantasy femininity represents both change and continuity. Feminine archetypes in women’s magazines, from fairytale princesses to Barbie dolls, reflect a wider post-Soviet cultural hybridisation, and show how Western women’s magazines have adapted to the Russian context. Furthermore, the article highlights readers’ ambiguous attitudes towards post-Soviet cultural trends linked to perceived Westernisation or globalisation, such as individualism, conspicuous consumption, and glamour

Физико-химические и биологические свойства биоподобного и референтного препаратов тканевого активатора плазминогена

Recombinant tissue plasminogen activator (international nonproprietary name — alteplase) which was developed by «GENERIUM» (Russia) and received a marketing authorisation in Russia is completely analogous to Actilyse® which is used to treat medical conditions accompanied by thrombosis, such as acute myocardial infarction, pulmonary embolism, and ischemic stroke. The aim of the study was to carry out a comprehensive comparison of physico-chemical and biological properties of Revelyse® and the reference product Actilyse® in order to assess their biosimilarity. Materials and Methods: comparative peptide mapping and determination of comparability of chromatographic profiles of tryptic hydrolysates was performed using RP-HPLC and massspectrometry; the molecular weight distribution was determined by mass-spectrometry and polyacrylamide gel electrophoresis (Laemmli method). The purity and homogeneity of products as well as the content of related impurities (oligomers and fragments) were determined using gel filtration; N-glycosylation profile was analysed by hydrophilic HPLC, total sialic acid was quantified by the Svennerholm resorcinol method. Protein binding to fibrin and human fibrinogen was assessed by surface plasmon resonance, and the specific activity was compared by fibrin clot lysis. Results: the research demonstrated a complete overlap of the products’ peptide maps, which indicates the identity of аlteplase amino acid sequences in the two medicines being compared. The authors of the study also determined the molecular weight and the content of the intact single-stranded form of the protein, and quantified post-translational modifications, the content of sialic acids and neutral sugars. The analysis of the N-glycosylation profile revealed insignificant differences in the percentage of multiantenna complex glycans. The specificity of alteplase was evaluated by analysing the formation of protein complexes with natural alteplase ligands – fibrin and plasminogen activator inhibitor-1, but no significant differences were found. The comparison of specific activation of plasminogen fibrinolytic activity was performed based on the results of the assay analysing the fibrin clot lysis rate, and it demonstrated comparability of Revelyse® and Actilyse®. Conclusions: comparative experimental studies have shown no differences in the structure, charge distribution heterogeneity, impurities content, and specific activity of alteplase as a component of Revelyse® and the reference product Actilyse®, which leads to the conclusion that they are similar in terms of physicochemical and biological properties.Рекомбинантный тканевой активатор плазминогена (международное непатентованное название — алтеплаза), разработанный и зарегистрированный компанией АО «ГЕНЕРИУМ» (Россия), является полным аналогом лекарственного препарата Актилизе®, используемого для лечения заболеваний, сопровождающихся тромбообразованием, таких как инфаркт миокарда, тромбоэмболия легочной артерии и ишемический инсульт. Цель работы: провести комплексное исследование сопоставимости физико-химических и биологических характеристик лекарственного препарата Ревелиза® и референтного препарата Актилизе® для оценки их биоподобия. Материалы и методы: сравнительное пептидное картирование с определением сопоставимости хроматографических профилей триптических гидролизатов проводилось методами ОФ-ВЭЖХ и масс-спектрометрии, определение молекулярно-массового распределения — методами масс-спектрометрии и электрофореза в полиакриламидном геле по Леммли. Для определения чистоты и гомогенности препаратов, а также содержания родственных примесей (олигомеров, фрагментов) использовали метод гель-фильтрации; исследование профиля N-гликозилирования осуществляли методом гидрофильной ВЭЖХ, определение тотального содержания сиаловых кислот — методом Свеннерхольма. Оценку связывания белка с фибрином и фибриногеном человека проводили методом поверхностного плазмонного резонанса, сравнение специфической активности — методом лизиса фибринового сгустка. Результаты: в ходе исследований было продемонстрировано полное совпадение пептидных карт анализируемых препаратов, что свидетельствует об идентичности аминокислотной последовательности алтеплазы в составе сравниваемых препаратов. Также сравнительно были определены молекулярная масса и содержание интактной одноцепочечной формы белка в лекарственных препаратах, количественно охарактеризованы посттрансляционные модификации, содержание сиаловых кислот и нейтральных сахаров. При изучении профиля N-гликозилирования обнаружены незначительные различия в процентном содержании мультиантенных комплексных гликанов. Специфичность алтеплазы оценивали при образовании белковых комплексов с природными лигандами алтеплазы — фибрином и ингибитором активатора плазминогена первого типа, при этом достоверных различий обнаружено не было. При сравнении специфической активации фибринолитической активности плазминогена в тесте на скорость лизиса фибринового сгустка была продемонстрирована сопоставимость препаратов Ревелиза® и Актилизе®. Выводы: проведенные сравнительные экспериментальные исследования показали отсутствие различий в структуре, гетерогенности распределения зарядов, содержании примесей, а также специфической активности алтеплазы в составе лекарственного препарата Ревелиза® и референтного препарата Актилизе®, что позволяет сделать вывод о сопоставимости препаратов по физико-химическим и биологическим свойствам