Sceloporus cautus

Number of Pages: 5Integrative BiologyGeological Science

Temperature perturbation model of the opto-galvanic effect in CO2-laser discharges

A detailed discharge model of the opto-galvanic effect in molecular laser gas mixtures is developed based on the temperature perturbation or discharge cooling mechanism of Smith and Brooks (1979). Excellent agreement between the model and experimental results in CO2 laser gas mixtures is obtained. The model should be applicable to other molecular systems where the OGE is being used for laser stabilisation and as a spectroscopic tool

Delta-like and gtl2 are reciprocally expressed, differentially methylated linked imprinted genes on mouse chromosome 12

AbstractThe distal portion of mouse chromosome 12 is imprinted. To date, however, Gtl2 is the only imprinted gene identified on chromosome 12. Gtl2 encodes multiple alternatively spliced transcripts with no apparent open reading frame. Using conceptuses with maternal or paternal uniparental disomy for chromosome 12 (UPD12), we found that Gtl2 is expressed from the maternal allele and methylated at the 5′ end of the silent paternal allele. A reciprocally imprinted gene, Delta-like (Dlk), with homology to genes involved in the Notch signalling pathway was identified 80kb upstream of Gtl2. Dlk was expressed exclusively from the paternal allele in both the embryo and placenta, but the CpG-island promoter of Dlk was completely unmethylated on both parental alleles. Rather, a paternally methylated region was identified in the last exon of the active Dlk allele. The proximity, reciprocal imprinting and methylation in this domain are reminiscent of the co-ordinately regulated Igf2–H19 imprinted domain on mouse chromosome 7. Like H19 and Igf2, Gtl2 and Dlk were found to be co-expressed in the same tissues throughout development, though not after birth. These results have implications for the regulation, function and evolution of imprinted domains

Deep UV Luminosity Functions at the Infall Region of the Coma Cluster

We have used deep GALEX observations at the infall region of the Coma cluster to measure the faintest UV luminosity functions (LFs) presented for a rich galaxy cluster thus far. The Coma UV LFs are measured to M_UV = -10.5 in the GALEX FUV and NUV bands, or 3.5 mag fainter than previous studies, and reach the dwarf early-type galaxy population in Coma for the first time. The Schechter faint-end slopes (alpha = -1.39 in both GALEX bands) are shallower than reported in previous Coma UV LF studies owing to a flatter LF at faint magnitudes. A Gaussian-plus-Schechter model provides a slightly better parametrization of the UV LFs resulting in a faint-end slope of ~ -1.15 in both GALEX bands. The two-component model gives faint-end slopes shallower than -1 (a turnover) for the LFs constructed separately for passive and star forming galaxies. The UV LFs for star forming galaxies show a turnover at M_UV ~ -14 owing to a deficit of dwarf star forming galaxies in Coma with stellar masses below M*=10^8 Msun. A similar turnover is identified in recent UV LFs measured for the Virgo cluster suggesting this may be a common feature of local galaxy clusters, whereas the field UV LFs continue to rise at faint magnitudes. We did not identify an excess of passive galaxies as would be expected if the missing dwarf star forming galaxies were quenched inside the cluster. In fact, the LFs for both dwarf passive and star forming galaxies show the same turnover at faint magnitudes. We discuss the possible origin of the missing dwarf star forming galaxies in Coma and their expected properties based on comparisons to local field galaxies.Comment: accepted for publication in Ap

Perturbations to the IGF1 growth pathway and adult energy homeostasis following disruption of mouse chromosome 12 imprinting

AIM: Disruption to insulin-like growth factor (IGF) signalling pathways during early life causes growth retardation and defects of developing metabolic organs that can alter set points of energy homeostasis for a lifetime. Inheritance of two maternal copies of human chromosome 14q32.2 (Temple syndrome) causes severe foetal growth retardation and post-natal failure to thrive. Disruption of imprinted gene dosage in the orthologous region on mouse chromosome 12 also affects growth. Here, we investigated whether altering chromosome 12-imprinted gene dosage can affect IGF signalling. METHODS: We investigated mice with a transgene insertion at the imprinted domain of chromosome 12. This lesion causes misexpression of neighbouring genes such that the expression of non-coding RNAs is elevated, and levels of delta-like homologue 1 (Dlk1), retrotransposon-like 1 (Rtl1) and deiodinase 3 (Dio3) transcripts are reduced. RESULTS: We observed three key phenotypes in these mice: (i) embryonic growth retardation associated with altered expression of IGF1 binding proteins, (ii) peri-natal failure to thrive accompanied by hypothyroidism and low serum IGF1. Unexpectedly this phenotype was growth hormone independent. (iii) Adult animals had reduced glucose tolerance as a result of endocrine pancreatic insufficiency. CONCLUSIONS: We propose that all of these phenotypes are attributable to impaired IGF action and show for the first time that the chromosome 12 cluster in the mouse is an imprinted locus that modulates the IGF signalling pathway. We propose that growth retardation observed in human Temple syndrome might have a similar cause

Preventing childhood malaria in Africa by protecting adults from mosquitoes with insecticide-treated nets

Malaria prevention in Africa merits particular attention as the world strives toward a better life for the poorest. Insecticide-treated nets (ITNs) represent a practical means to prevent malaria in Africa, so scaling up coverage to at least 80% of young children and pregnant women by 2010 is integral to the Millennium Development Goals (MDG). Targeting individual protection to vulnerable groups is an accepted priority, but community-level impacts of broader population coverage are largely ignored even though they may be just as important. We therefore estimated coverage thresholds for entire populations at which individual- and community-level protection are equivalent, representing rational targets for ITN coverage beyond vulnerable groups

Age Constraints for an M31 Globular Cluster from Main Sequence Photometry

We present a color-magnitude diagram (CMD) of the globular cluster SKHB-312 in the Andromeda galaxy (M31), obtained with the Advanced Camera for Surveys on the Hubble Space Telescope. The cluster was included in deep observations taken to measure the star formation history of the M31 halo. Overcoming a very crowded field, our photometry of SKHB-312 reaches V ~ 30.5 mag, more than 1 mag below the main sequence turnoff. These are the first observations to allow a direct age estimate from the turnoff in an old M31 cluster. We analyze its CMD and luminosity function using a finely-spaced grid of isochrones that have been calibrated using observations of Galactic clusters taken with the same camera and filters. The luminosity difference between the subgiant and horizontal branches is ~0.2 mag smaller in SKHB-312 than in the Galactic clusters 47 Tuc and NGC 5927, implying SKHB-312 is 2-3 Gyr younger. A quantitative comparison to isochrones yields an age of 10 +2.5/-1 Gyr

RR Lyrae Stars in the Andromeda Halo from Deep Imaging with the Advanced Camera for Surveys

We present a complete census of RR Lyrae stars in a halo field of the Andromeda galaxy. These deep observations, taken as part of a program to measure the star formation history in the halo, spanned a period of 41 days with sampling on a variety of time scales, enabling the identification of short and long period variables. Although the long period variables cannot be fully characterized within the time span of this program, the enormous advance in sensitivity provided by the Advanced Camera for Surveys on the Hubble Space Telescope allows accurate characterization of the RR Lyrae population in this field. We find 29 RRab stars with a mean period of 0.594 days, 25 RRc stars with a mean period of 0.316 days, and 1 RRd star with a fundamental period of 0.473 days and a first overtone period of 0.353 days. These 55 RR Lyrae stars imply a specific frequency S_RR=5.6, which is large given the high mean metallicity of the halo, but not surprising given that these stars arise from the old, metal-poor tail of the distribution. This old population in the Andromeda halo cannot be clearly placed into one of the Oosterhoff types: the ratio of RRc/RRabc stars is within the range seen in Oosterhoff II globular clusters, the mean RRab period is in the gap between Oosterhoff types, and the mean RRc period is in the range seen in Oosterhoff I globular clusters. The periods of these RR Lyraes suggest a mean metallicity of [Fe/H]=-1.6, while their brightness implies a distance modulus to Andromeda of 24.5+/-0.1, in good agreement with the Cepheid distance.Comment: 15 pages, latex. Accepted for publication in The Astronomical Journa

Far-Ultraviolet Emission from Elliptical Galaxies at z=0.33

We present far-ultraviolet (far-UV) images of the rich galaxy cluster ZwCl1358.1+6245, taken with the Space Telescope Imaging Spectrograph on board the Hubble Space Telescope (HST). When combined with archival HST observations, our data provide a measurement of the UV-to-optical flux ratio in 8 early-type galaxies at z=0.33. Because the UV flux originates in a population of evolved, hot, horizontal branch (HB) stars, this ratio is potentially one of the most sensitive tracers of age in old populations -- it is expected to fade rapidly with lookback time. We find that the UV emission in these galaxies, at a lookback time of 3.9 Gyr, is significantly weaker than it is in the current epoch, yet similar to that in galaxies at a lookback time of 5.6 Gyr. Taken at face value, these measurements imply different formation epochs for the massive ellipticals in these clusters, but an alternative explanation is a "floor" in the UV emission due to a dispersion in the parameters that govern HB morphology.Comment: 4 pages, Latex. 2 figures. Uses corrected version of emulateapj.sty and apjfonts.sty (included). Accepted for publication in ApJ Letter