Localization of N-acyl phosphatidylethanolamine phospholipase D (NAPE-PLD) expression in mouse brain: A new perspective on N-acylethanolamines as Neural Signaling Molecules

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Asymptotic boundary forms for tight Gabor frames and lattice localization domains

We consider Gabor localization operators $G_{\phi,\Omega}$ defined by two parameters, the generating function $\phi$ of a tight Gabor frame $\{\phi_\lambda\}_{\lambda \in \Lambda}$, parametrized by the elements of a given lattice $\Lambda \subset \Bbb{R}^2$, i.e. a discrete cocompact subgroup of $\Bbb{R}^2$, and a lattice localization domain $\Omega \subset \Bbb{R}^2$ with its boundary consisting of line segments connecting points of $\Lambda$. We find an explicit formula for the boundary form $BF(\phi,\Omega)=\text{A}_\Lambda \lim_{R\rightarrow \infty}\frac{PF(G_{\phi,R\Omega})}{R}$, the normalized limit of the projection functional $PF(G_{\phi,\Omega})=\sum_{i=0}^{\infty}\lambda_i(G_{\phi,\Omega})(1-\lambda_i(G_{\phi,\Omega}))$, where $\lambda_i(G_{\phi,\Omega})$ are the eigenvalues of the localization operators $G_{\phi,\Omega}$ applied to dilated domains $R\Omega$, $R$ is an integer and $\text{A}_\Lambda$ is the area of the fundamental domain of the lattice $\Lambda$.Comment: 35 page

Multiscreen serum analysis of highly sensitized renal dialysis patients for antibodies toward public and private class I HLA determinants: Implications for computer-predicted acceptable and unacceptable donor mismatches in kidney transplantation

A multiscreen serum analysis program has been developed that permits a determination of antibody specificity for the vast majority of highly sensitized patients awaiting transplantation. This program is based on a 2 x 2 table analysis of correlations between serum reactivity with an HLA-typed cell panel and incorporates two modifications. One implements the concept of public HLA determinants based on the serologic crossreactivity among class I HLA antigens. The other modification derives from the premise that most highly sensitized patients maintain the same PRA and antibody profiles over many months and even years. Monthly screening results for patients with persistent PRA values can therefore be combined for analysis. For 132 of 150 highly sensitized patients with >50% PRA, this multiscreen serum analysis program yielded information about antibody specificity toward public and private class IHLA determinants. The vast majority of patients (108 of 112) with PRA values between 50 and 89% showed antibody specificity generally toward one, two, or three public markers and/or the more common private HLA-A, B antigens. For 24 of 38 patients with >90% PRA, it was possible to define one or few HLA-specific antibodies. The primary objective of the multiscreen program was to develop an algorithm about computer-predicted acceptable and unacceptable donor HLA-A, B antigens for patients with preformed antibodies. A retrospective analysis of kidney transplants into 89 highly sensitized patients has demonstrated that allografts with unacceptable HLA-A, B mismatches had significantly lower actuarial survival rates than those with acceptable mismatches (P = 0.01). This was shown for both groups of 32 primary transplants (44% vs. 67% after 1 year) and 60 retransplants (50% vs. 68%). Also, serum creatinine levels were significantly higher in patients with unacceptable class I mismatches (3.0 vs. 8.4 mg% [P = 0.007] after 2 weeks; 3.9 vs. 9.1 mg% [P = 0.014] after 4 weeks). Histopathologic analysis of allograft tissue specimens from 47 transplant recipients revealed a significantly higher incidence of humoral rejection (P = 0.02), but not cellular rejection, in the unacceptable mismatch group. These results suggest that the multiscreen program can establish which donor HLA-A, B mismatches must be avoided in kidney transplantation for most highly sensitized patients. For 18 of 150 high PRA renal dialysis patients, the multiscreen program could not define HLA-specific antibody. Most patients had >90% PRA, and many of their sera appeared to contain IgM type nonspecific lympho- cytotoxins that could be inactivated by dithioerythreitol (DTE). Preliminary studies have shown that this treatment enabled the detection of HLA-specific antibodies upon subsequent screening on many occasions. These data suggest that non-HLA specific reactivity revealed by multiscreen analysis can often be removed by DTE treatment. Multiscreen analysis offers an attractive approach to regional organ-sharing programs for highly sensitized renal transplant candidates. It enables the development of an efficient strategy for donor selection based on the computer assignment of acceptable HLA-A, B mismatches for each patient. © 1990 by Williams and Wilkins

PATENT LICENSING BY MEANS OF AN AUCTION: INTERNAL VS. EXTERNAL PATENTEE

An independent research laboratory owns a patented process innovation that can be licensed by means of an auction to two Cournot duopolists producing differentiated goods. For large innovations and close enough substitute goods the patentee auctions o¤ only one license, preventing the full diffusion of the innovation. For this range of parameters, however, if the laboratory merged with one of the firms in the industry, full technology diffusion would be implemented as the merged entity would always license the innovation to the rival firm. This explains that, in this context, a vertical merger is both profitable and welfare improving.Patent licensing, two-part tariff contracts, vertical mergers

Characterization of Burkholderia cepacia genomovar I as a potential biocontrol agent of Ganoderma boninense in oil palm

Burkholderia is an important bacterial genus containing several species of ecological, biotechnological and pathological interest. Bacterial isolate can be gotten from soil, water, plants and even clinics. With their taxonomy undergoing constant revision and the phenotypic similarity of several species, correct identification of Burkholderia is difficult. Burkholderia cepacia complex (Bcc) consists of nine discrete genomic species and a genetic scheme based on the recA gene has greatly enhanced the identification of B. cepacia complex species. The objectives of this study were to identify Burkholderia strain UPM B3 which was isolated from oil palm roots to the species level based on Biolog® Identification System, and to carry out DNA fingerprinting for strain differentiation as well as differentiate between pathogenic and non-pathogenic human forms. Antagonistic activity of UPM B3 against Ganoderma boninense was alsoevaluated by using dual culture and poison food tests. Genotype characterization was carried out by amplification of the recA gene using specific primers, purified using QIA Quick polymerase chain reaction (PCR) purification kit and sequenced. Multiple sequence alignments were performed on closely related sequence accessions using CLUSTAL W software. Result of nucleotide sequencing followed by phylogenetic analysis of the recA fragments differentiated both putative and known Burkholderiaspecies and all members of the B. cepacia complex. Genomovar analysis confirmed that UPM B3, isolated from oil palm roots belongs to genomovar I and has antagonistic activity against G. boninense based on in vitro dual culture and poison food tests. From the phylogenetic tree, UPM B3 is a specific strain within B. cepacia complex species that belong to genovomar I which is associated with strains nonpathogenic to humans. Thus, B. cepacia strain UPM B3 has the potential to be used against G.boninense, the causal pathogen of basal stem rot (BSR) in oil palm

Iterative forcing and hyperimmunity in reverse mathematics

The separation between two theorems in reverse mathematics is usually done by constructing a Turing ideal satisfying a theorem P and avoiding the solutions to a fixed instance of a theorem Q. Lerman, Solomon and Towsner introduced a forcing technique for iterating a computable non-reducibility in order to separate theorems over omega-models. In this paper, we present a modularized version of their framework in terms of preservation of hyperimmunity and show that it is powerful enough to obtain the same separations results as Wang did with his notion of preservation of definitions.Comment: 15 page

西沙珊瑚鍶溫度計: 便捷高精度海洋古水溫代用指標

Strontium concentrations in modem Porites coral from XishaIslands were determined by precise thermal ionization mass spectrometry. The coral skeleton grew in the period from 1976 to 1994. The results indicate that the variability of coral Sr is periodically at annual cycles, and is in agreement with in situ measured sea surface temperature (SST). The calibration of Sr and SST with correlation coefficient r = -0. 94 has been developed at monthly sampling resolution. In addition, maximum and minimum seasonal monthly Sr and SST values were also regressed for the 18-year interval, and the correlation coefficient is -0. 98. The error of this Sr thermometer is better than 0. 5 ℃.西沙群島現代濱珊瑚1976～1994年生長期間Sr含量的高精度熱電離質譜測定結果表明，Sr含量隨季節發生周期性的變化，并與當地同期實測海水月平均溫度變化相吻合，其Sr含量與實測海水溫度相關系數為-0.94。這18年冬夏季極端Sr含量與同期月溫的相關系數可高達-0.98。Sr溫度計誤差小于0.5℃。published_or_final_versio

Characteristic Energy of the Coulomb Interactions and the Pileup of States

Tunneling data on $\mathrm{La_{1.28}Sr_{1.72}Mn_2O_7}$ crystals confirm Coulomb interaction effects through the $\sqrt{\mathrm{E}}$ dependence of the density of states. Importantly, the data and analysis at high energy, E, show a pileup of states: most of the states removed from near the Fermi level are found between ~40 and 130 meV, from which we infer the possibility of universal behavior. The agreement of our tunneling data with recent photoemission results further confirms our analysis.Comment: 4 pages, 4 figures, submitted to PR