Bacterial infections of the pulmonary system are increasing.</p

leo, BF

López-Heras, M

Porter, AE

Ryan, M

Theodorou, I

Environmental Science Nano

English

13.07.15 KB. Ok to add accepted version, subject to 12 months embargo from acceptanceBacterial infections of the pulmonary system are increasing. With almost half of today's infections being
caused by strains of bacteria that are resistant to existing conventional antibiotics, there is an urgent need
for the development of novel therapeutic platforms. Silver nanoparticles (AgNPs) have been receiving
increasing attention due to their unique antibacterial properties, and whilst the biological efficacy of silver
is well known, the mechanisms by which AgNPs degrade within cells and how these processes correlate to
their  bioreactivity  are  poorly  understood.  This  review  summarises  the  current  knowledge  on  the
bactericidal pathways of AgNPs and discusses the challenges to be faced before we are able to develop
efficient and safe antibacterial agents for the treatment of bacterial infections in the lung

Spiral - Imperial College Digital Repository

Towards understanding the antibacterial activity of Ag nanoparticles: electron microscopy in the analysis of the materials-biology interface in the lung

M. López-Heras

I. G. Theodorou

B. F. Leo

M. P. Ryan

A. E. Porter

Crossref

http://spiral.imperial.ac.uk/bitstream/10044/1/25009/5/Lopez-Heras_Towards%20understanding%20antibacterial_Env%20sci%20nano.pdf

Towards understanding the antibacterial activity of Ag nanoparticles: electron microscopy in the analysis of the materials-biology interface in the lung

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