Multi-Estimator Full Left Ventricle Quantification through Ensemble Learning

Cardiovascular disease accounts for 1 in every 4 deaths in United States. Accurate estimation of structural and functional cardiac parameters is crucial for both diagnosis and disease management. In this work, we develop an ensemble learning framework for more accurate and robust left ventricle (LV) quantification. The framework combines two 1st-level modules: direct estimation module and a segmentation module. The direct estimation module utilizes Convolutional Neural Network (CNN) to achieve end-to-end quantification. The CNN is trained by taking 2D cardiac images as input and cardiac parameters as output. The segmentation module utilizes a U-Net architecture for obtaining pixel-wise prediction of the epicardium and endocardium of LV from the background. The binary U-Net output is then analyzed by a separate CNN for estimating the cardiac parameters. We then employ linear regression between the 1st-level predictor and ground truth to learn a 2nd-level predictor that ensembles the results from 1st-level modules for the final estimation. Preliminary results by testing the proposed framework on the LVQuan18 dataset show superior performance of the ensemble learning model over the two base modules.Comment: Jiasha Liu, Xiang Li and Hui Ren contribute equally to this wor

Millicharged Atomic Dark Matter

We present a simplified version of the atomic dark matter scenario, in which charged dark constituents are bound into atoms analogous to hydrogen by a massless hidden sector U(1) gauge interaction. Previous studies have assumed that interactions between the dark sector and the standard model are mediated by a second, massive Z' gauge boson, but here we consider the case where only a massless gamma' kinetically mixes with the standard model hypercharge and thereby mediates direct detection. This is therefore the simplest atomic dark matter model that has direct interactions with the standard model, arising from the small electric charge for the dark constituents induced by the kinetic mixing. We map out the parameter space that is consistent with cosmological constraints and direct searches, assuming that some unspecified mechanism creates the asymmetry that gives the right abundance, since the dark matter cannot be a thermal relic in this scenario. In the special case where the dark "electron" and "proton" are degenerate in mass, inelastic hyperfine transitions can explain the CoGeNT excess events. In the more general case, elastic transitions dominate, and can be close to current direct detection limits over a wide range of masses.Comment: 5 pages, 2 figures; v2: added references, and formula for dark ionization fraction; published versio

Scheme for remote implementation of partially unknown quantum operation of two qubits in cavity QED

By constructing the recovery operations of the protocol of remote implementation of partially unknown quantum operation of two qubits [An Min Wang: PRA, \textbf{74}, 032317(2006)], we present a scheme to implement it in cavity QED. Long-lived Rydberg atoms are used as qubits, and the interaction between the atoms and the field of cavity is a nonresonant one. Finally, we analyze the experimental feasibility of this scheme.Comment: 7 pages, 2 figure

Triaxially deformed relativistic point-coupling model for Λ\Lambda hypernuclei: a quantitative analysis of hyperon impurity effect on nuclear collective properties

The impurity effect of hyperon on atomic nuclei has received a renewed interest in nuclear physics since the first experimental observation of appreciable reduction of $E2$ transition strength in low-lying states of hypernucleus $^{7}_\Lambda$Li. Many more data on low-lying states of $\Lambda$ hypernuclei will be measured soon for $sd$-shell nuclei, providing good opportunities to study the $\Lambda$ impurity effect on nuclear low-energy excitations. We carry out a quantitative analysis of $\Lambda$ hyperon impurity effect on the low-lying states of $sd$-shell nuclei at the beyond-mean-field level based on a relativistic point-coupling energy density functional (EDF), considering that the $\Lambda$ hyperon is injected into the lowest positive-parity ($\Lambda_s$) and negative-parity ($\Lambda_p$) states. We adopt a triaxially deformed relativistic mean-field (RMF) approach for hypernuclei and calculate the $\Lambda$ binding energies of hypernuclei as well as the potential energy surfaces (PESs) in $(\beta, \gamma)$ deformation plane. We also calculate the PESs for the $\Lambda$ hypernuclei with good quantum numbers using a microscopic particle rotor model (PRM) with the same relativistic EDF. The triaxially deformed RMF approach is further applied in order to determine the parameters of a five-dimensional collective Hamiltonian (5DCH) for the collective excitations of triaxially deformed core nuclei. Taking $^{25,27}_{\Lambda}$Mg and $^{31}_{\Lambda}$Si as examples, we analyse the impurity effects of $\Lambda_s$ and $\Lambda_p$ on the low-lying states of the core nuclei...Comment: 15 pages with 18 figures and 1 table (version to be published in Physical Review C

Genome organization and interaction with capsid protein in a multipartite RNA virus.

We report the asymmetric reconstruction of the single-stranded RNA (ssRNA) content in one of the three otherwise identical virions of a multipartite RNA virus, brome mosaic virus (BMV). We exploit a sample consisting exclusively of particles with the same RNA content-specifically, RNAs 3 and 4-assembled in planta by agrobacterium-mediated transient expression. We find that the interior of the particle is nearly empty, with most of the RNA genome situated at the capsid shell. However, this density is disordered in the sense that the RNA is not associated with any particular structure but rather, with an ensemble of secondary/tertiary structures that interact with the capsid protein. Our results illustrate a fundamental difference between the ssRNA organization in the multipartite BMV viral capsid and the monopartite bacteriophages MS2 and Qβ for which a dominant RNA conformation is found inside the assembled viral capsids, with RNA density conserved even at the center of the particle. This can be understood in the context of the differing demands on their respective lifecycles: BMV must package separately each of several different RNA molecules and has been shown to replicate and package them in isolated, membrane-bound, cytoplasmic complexes, whereas the bacteriophages exploit sequence-specific "packaging signals" throughout the viral RNA to package their monopartite genomes