982 research outputs found
Genetic effects on longitudinal cognitive decline during the early stages of Alzheimer's disease
Cognitive decline in early-stage Alzheimer’s disease (AD) may depend on genetic variability. In the Swedish BioFINDER study, we used polygenic scores (PGS) (for AD, intelligence, and educational attainment) to predict longitudinal cognitive change (measured by mini-mental state examination (MMSE) [primary outcome] and other cognitive tests) over a mean of 4.2 years. We included 260 β-amyloid (Aβ) negative cognitively unimpaired (CU) individuals, 121 Aβ-positive CU (preclinical AD), 50 Aβ-negative mild cognitive impairment (MCI) patients, and 127 Aβ-positive MCI patients (prodromal AD). Statistical significance was determined at Bonferroni corrected p value < 0.05. The PGS for intelligence (beta = 0.1, p = 2.9e−02) was protective against decline in MMSE in CU and MCI participants regardless of Aβ status. The polygenic risk score for AD (beta = − 0.12, p = 9.4e−03) was correlated with the rate of change in MMSE and was partially mediated by Aβ-pathology (mediation effect 20%). There was no effect of education PGS on cognitive measures. Genetic variants associated with intelligence mitigate cognitive decline independent of Aβ-pathology, while effects of genetic variants associated with AD are partly mediated by Aβ-pathology
An Improved High Order Finite Difference Method for Non-conforming Grid Interfaces for the Wave Equation
This paper presents an extension of a recently developed high order finite difference method for the wave equation on a grid with non-conforming interfaces. The stability proof of the existing methods relies on the interpolation operators being norm-contracting, which is satisfied by the second and fourth order operators, but not by the sixth order operator. We construct new penalty terms to impose interface conditions such that the stability proof does not require the norm-contracting condition. As a consequence, the sixth order accurate scheme is also provably stable. Numerical experiments demonstrate the improved stability and accuracy property
Zero-temperature responses of a 3D spin glass in a field
We probe the energy landscape of the 3D Edwards-Anderson spin glass in a
magnetic field to test for a spin glass ordering. We find that the spin glass
susceptibility is anomalously large on the lattice sizes we can reach. Our data
suggest that a transition from the spin glass to the paramagnetic phase takes
place at B_c=0.65, though the possibility B_c=0 cannot be excluded. We also
discuss the question of the nature of the putative frozen phase.Comment: RevTex, 4 pages, 4 figures, clarifications and added reference
Weighed scalar averaging in LTB dust models, part I: statistical fluctuations and gravitational entropy
We introduce a weighed scalar average formalism ("q-average") for the study
of the theoretical properties and the dynamics of spherically symmetric
Lemaitre-Tolman-Bondi (LTB) dust models models. The "q-scalars" that emerge by
applying the q-averages to the density, Hubble expansion and spatial curvature
(which are common to FLRW models) are directly expressible in terms of
curvature and kinematic invariants and identically satisfy FLRW evolution laws
without the back-reaction terms that characterize Buchert's average. The local
and non-local fluctuations and perturbations with respect to the q-average
convey the effects of inhomogeneity through the ratio of curvature and
kinematic invariants and the magnitude of radial gradients. All curvature and
kinematic proper tensors that characterize the models are expressible as
irreducible algebraic expansions on the metric and 4-velocity, whose
coefficients are the q-scalars and their linear and quadratic local
fluctuations. All invariant contractions of these tensors are quadratic
fluctuations, whose q-averages are directly and exactly related to statistical
correlation moments of the density and Hubble expansion scalar. We explore the
application of this formalism to a definition of a gravitational entropy
functional proposed by Hosoya et al (2004 Phys. Rev. Lett. 92 141302). We show
that a positive entropy production follows from a negative correlation between
fluctuations of the density and Hubble scalar, providing a brief outline on its
fulfillment in various LTB models and regions. While the q-average formalism is
specially suited for LTB and Szekeres models, it may provide a valuable
theoretical insight on the properties of scalar averaging in inhomogeneous
spacetimes in general.Comment: 27 pages in IOP format, 1 figure. Matches version accepted for
publication in Classical and Quantum Gravit
Ising Spin Glasses in a Magnetic Field
Ground states of the three dimensional Edwards-Anderson spin glass are
computed in the presence of an external magnetic field. Our algorithm is
sufficiently powerful for us to treat systems with up to 600 spins. We perform
a statistical analysis of how the ground state changes as the field is
increased, and reach the conclusion that the spin glass phase at zero
temperature does not survive in the presence of any finite field. This is in
agreement with the droplet model or scaling predictions, but in sharp
disagreement with the mean field picture. For comparison, we also investigate a
dilute mean field spin glass model where an Almeida-Thouless line is present.Comment: 4 pages, 4 figures, Revte
Friedel oscillations in a two-band Hubbard model for CuO chains
Friedel oscillations induced by open boundary conditions in a two-band
Hubbard model for CuO chains are numerically studied. We find that for
physically realistic parameters and close to quarter filling, these
oscillations have a 2k_F modulation according with experimental results on
YBa_2Cu_3O_{7-delta}. In addition, we predict that, for the same parameters, as
hole doping is reduced from quarter filling to half filling, Friedel
oscillations would acquire a 4k_F modulation, typical of a strongly correlated
electrons regime. The 4k_F modulation dominates also in the electron doped
region. The range of parameters varied is very broad, and hence the results
reported could apply to other cuprates and other strongly correlated compounds
with quasi-one dimensional structures. On a more theoretical side, we stress
the fact that the copper and oxygen subsystems should be described by two
different Luttinger liquid exponents.Comment: 7 pages, 7 eps figure
Neel order in doped quasi one-dimensional antiferromagnets
We study the Neel temperature of quasi one-dimensional S=1/2 antiferromagnets
containing non-magnetic impurities. We first consider the temperature
dependence of the staggered susceptibility of finite chains with open boundary
conditions, which shows an interesting difference for even and odd length
chains. We then use a mean field theory treatment to incorporate the three
dimensional inter-chain couplings. The resulting Neel temperature shows a
pronounced drop as a function of doping by up to a factor of 5.Comment: 4 pages in revtex4 format including 2 epsf-embedded figures. The
latest version in PDF format is available from
http://fy.chalmers.se/~eggert/papers/staggered.pd
Metal Surface Energy: Persistent Cancellation of Short-Range Correlation Effects beyond the Random-Phase Approximation
The role that non-local short-range correlation plays at metal surfaces is
investigated by analyzing the correlation surface energy into contributions
from dynamical density fluctuations of various two-dimensional wave vectors.
Although short-range correlation is known to yield considerable correction to
the ground-state energy of both uniform and non-uniform systems, short-range
correlation effects on intermediate and short-wavelength contributions to the
surface formation energy are found to compensate one another. As a result, our
calculated surface energies, which are based on a non-local
exchange-correlation kernel that provides accurate total energies of a uniform
electron gas, are found to be very close to those obtained in the random-phase
approximation and support the conclusion that the error introduced by the
local-density approximation is small.Comment: 5 pages, 1 figure, to appear in Phys. Rev.
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