On classical n-absorbing submodules

In this paper, we introduce the notion of classical n-absorbing submodules of a module M over a commutative ring R with identity, which is a generalization of classical prime submodules. A proper submodule N of M is said to be classical n-absorbing if whenever a1a2... an+1 m in M, for a1a2... an+1 in R and m in M, then there are n of the ai's whose product with m is in N. We give some basic results concerning classical n-absorbing submodules. Then the classical n-absorbing avoidance theorem for submodules is proved. Finally, classical n-absorbing submodules in several classes of modules are studied

Computational screening of known broad-spectrum antiviral small organic molecules for potential influenza HA stem inhibitors.

With the emergence of new influenza virus strains that are resistant to current inhibitors such as oseltamivir (anti-neuraminidase (NA)) and amantadine (anti-M2 proton channel), influenza A viruses continue to be a serious threat to the public health worldwide. With this in view, there is a persistent need for the development of broader and more effective vaccines and therapeutics. Identification of broadly neutralizing antibodies (bNAbs) that recognize relatively invariant structures ‎on influenza haemagglutinin (HA) stem has invigorated efforts to develop universal influenza vaccines. The current computational study is designed to identify potential flavonoid inhibitors that bind to the contact epitopes of HA stem that are targeted by broadly neutralizing antibodies (bNAb). In this study, we utilized the three-dimensional crystallographic structure of different HA subtypes (H1, H2, H5, H3, and H7) in complex with bNAb to screen for potential broadly reactive influenza inhibitors. We performed Quantitative Structure-Activity and Relationship (QSAR) for 100 natural compounds known for their antiviral activity and performed molecular docking using AutoDock 4.2 suite. Furthermore, we conducted virtual screening of 1413 bioassay hit compounds by using virtual lab bench CLC Drug Discovery. The results showed 18 lead flavonoids with strong binding abilities to bNAb epitopes of various HA subtypes. These 18 broadly reactive compounds exhibited significant interactions with an average of seven Hbonds, docking energy of -22.43 kcal·mol-1, and minimum interaction ‎ energy of -4.65 kcal·mol-1, with functional contact residues. Procyanidin depicted strong interactions with group 1 HAs, whereas both sorbitol and procyanidin exhibited significant interactions with group 2 HAs. Using in silico docking analysis, we identified 18 bioactive flavonoids with potential strong binding cababilities to influenza HA-stems of various subtypes, which are the target for bNAb. The virtual screened bioassay hit compounds depicted a high number of Hbonds but low interaction and docking values compared to antiviral flavonoids. Using structure-based design and nanotechnology-based approaches, identified molecules could be modified to generate next generation anti-influenza drugs

Characterization of an H3N2 triple reassortant influenza virus with a mutation at the receptor binding domain (D190A) that occurred upon virus transmission from turkeys to pigs

The hemagglutinin (HA) protein of influenza virus mediates essential viral functions including the binding to host receptor and virus entry. It also has the antigenic sites required for virus neutralization by host antibodies. Here, we characterized an H3N2 triple reassortant (TR) influenza virus (A/turkey/Ohio/313053/04) with a mutation at the receptor binding domain (Asp190Ala) that occurred upon virus transmission from turkeys to pigs in an experimental infection study. The mutant virus replicated less efficiently than the parental virus in human, pig and turkey primary tracheal/bronchial epithelial cells, with more than 3-log10 difference in virus titer at 72 hours post infection. In addition, the mutant virus demonstrated lower binding efficiency to plasma membrane preparations from all three cell types compared to the parental virus. Antisera raised against the parental virus reacted equally to both homologous and heterlogous viruses, however, antisera raised against the mutant virus showed 4-8 folds lower reactivity to the parental virus

Quasinormal Modes and Optical Properties of 4-D black holes in Einstein Power-Yang-Mills Gravity

This paper explores the impact of the Yang-Mills charge parameter and the exponent term on a $4$D black hole solution in the Einstein Power-Yang-Mills theory. Through an investigation of the massless scalar quasinormal mode spectrum, black hole shadow, and emission rate, we have determined that the effects of these two parameters are opposite. Specifically, the Yang-Mills charge parameter causes an increase in the real quasinormal frequencies with a correspondingly smaller damping rate. It also results in a smaller black hole shadow and a lower evaporation rate.Comment: 13 pages, 9 figure

Assessing the impact of investments in Cross-border pipelines on the security of gas supply in the EU

The European Union (EU) is highly dependent on external natural gas supplies and has experienced severe gas cuts in the past, mainly driven by the technical complexity of the high-pressure natural gas system and political instability in some of the supplier countries. Declining indigenous natural gas production and growing demand for gas in the EU has encouraged investments in cross-border transmission capacity to increase the sharing of resources between the member states, particularly in the aftermath of the Russia-Ukraine gas crisis in January 2009. This article models the EU interconnected natural gas system to assess the impact of investments in the gas transmission network by comparing the performance of the system for scenarios of 2009 and 2017, using a mathematical optimization approach. The model uses the technical data of the infrastructures, such as production, storage, regasification, and exchange capacity through cross-border pipelines, and proposes an optimal collaborative strategy which ensures the best possible coverage of overall demand. The actual peak demand situations of the extreme cases of 2009 and 2017 are analyzed under hypothetical supply crises caused by geopolitical or commercial disputes. The application of the proposed methodology leads to results which show that the investments made in this system do not decongest the cross-border pipeline network but improve the demand coverage. Countries such as Spain and Italy experience a lower impact on gas supply due to the variety of mechanisms available to cover their demand. Furthermore, the findings prove that cooperation facilitates the supply of demand in crisis situations

Interspecies and intraspecies transmission of triple reassortant H3N2 influenza A viruses

The triple reassortant H3N2 viruses were isolated for the first time from pigs in 1998 and are known to be endemic in swine and turkey populations in the United States. In 2004, we isolated two H3N2 triple reassortant viruses from two turkey breeder flocks in Ohio and Illinois. Infected hens showed no clinical signs, but experienced a complete cessation of egg production. In this study, we evaluated three triple reassortant H3N2 isolates of turkey origin and one isolate of swine origin for their transmission between swine and turkeys. Although all 4 viruses tested share high genetic similarity in all 8 genes, only the Ohio strain (A/turkey/Ohio/313053/04) was shown to transmit efficiently both ways between swine and turkeys. One isolate, A/turkey/North Carolina/03, was able to transmit from pigs to turkeys but not vice versa. Neither of the other two viruses transmitted either way. Sequence analysis of the HA1 gene of the Ohio strain showed one amino acid change (D to A) at residue 190 of the receptor binding domain upon transmission from turkeys to pigs. The Ohio virus was then tested for intraspecies transmission in three different avian species. The virus was shown to replicate and transmit among turkeys, replicate but does not transmit among chickens, and did not replicate in ducks. Identifying viruses with varying inter- and intra-species transmission potential should be useful for further studies on the molecular basis of interspecies transmission

Two simple systems with cold atoms: quantum chaos tests and nonequilibrium dynamics

This article is an attempt to provide a link between the quantum nonequilibrium dynamics of cold gases and fifty years of progress in the lowdimensional quantum chaos. We identify two atomic systems lying on the interface: two interacting atoms in a harmonic multimode waveguide and an interacting two-component Bose-Bose mixture in a double-well potential. In particular, we study the level spacing distribution, the wavefunction statistics, the eigenstate thermalization, and the ability to thermalize in a relaxation process as such.Comment: 18 pages, 9 figure

Molecular epidemiology of Rotavirus in children with gastroenteritis in Qatar

Acute gastroenteritis remains a major cause of morbidity and mortality of young children worldwide. The vast majority of diarrhea cases in developing and developed countries are attributable to the viruses and to a lesser extent to bacteria, fungi and toxins. Rotavirus (RV) is recognized as the most important etiological agent leading to acute gastroenteritis globally. In order to determine the burden and characteristics of RV infections in children in Qatar, profiling of circulating genotypes and their correlation with demographics and clinical manifestations were evaluated