On The Low Frequency Quasi Periodic Oscillations of X-ray Sources

Based on the interpretation of the twin kilohertz Quasi Periodic Oscillations (kHz QPOs) of X-ray spectra of Low Mass X-Ray Binaries (LMXBs) to the Keplerian and the periastron precession frequencies at the magnetosphere-disk of X-ray neutron star (NS) respectively, we ascribe the low frequency Quasi Periodic Oscillations (LFQPO) and HBO (15-60 Hz QPO for Z sources or Atoll sources) to the periastron precession at some outer disk radius. The obtained conclusions include: all QPO frequencies increase with increasing the accretion rate. The obtained theoretical relations between HBO (LFQPO) frequency and the kHz QPO frequency are similar to the measured empirical formula. Further, the possible dynamical mechanism for QPO production is discussed.Comment: 6 pages, 2 figures, accepted by APSS, 200

Epicyclic oscillations of non-slender fluid tori around Kerr black holes

Considering epicyclic oscillations of pressure-supported perfect fluid tori orbiting Kerr black holes we examine non-geodesic (pressure) effects on the epicyclic modes properties. Using a perturbation method we derive fully general relativistic formulas for eigenfunctions and eigenfrequencies of the radial and vertical epicyclic modes of a slightly non-slender, constant specific angular momentum torus up to second-order accuracy with respect to the torus thickness. The behaviour of the axisymmetric and lowest-order ($m=\pm 1$) non-axisymmetric epicyclic modes is investigated. For an arbitrary black hole spin we find that, in comparison with the (axisymmetric) epicyclic frequencies of free test particles, non-slender tori receive negative pressure corrections and exhibit thus lower frequencies. Our findings are in qualitative agreement with the results of a recent pseudo-Newtonian study of analogous problem defined within the Paczy{\'n}ski-Wiita potential. Implications of our results on the high-frequency QPO models dealing with epicyclic oscillations are addressed.Comment: 24 pages, 8 figure

The burden of proof: the current state of atrial fibrillation prevention and treatment trials

Atrial fibrillation (AF) is an age-related arrhythmia of enormous socioeconomic significance. In recent years, our understanding of the basic mechanisms that initiate and perpetuate AF has evolved rapidly, catheter ablation of AF has progressed from concept to reality, and recent studies suggest lifestyle modification may help prevent AF recurrence. Emerging developments in genetics, imaging, and informatics also present new opportunities for personalized care. However, considerable challenges remain. These include a paucity of studies examining AF prevention, modest efficacy of existing antiarrhythmic therapies, diverse ablation technologies and practice, and limited evidence to guide management of high-risk patients with multiple comorbidities. Studies examining the long-term effects of AF catheter ablation on morbidity and mortality outcomes are not yet completed. In many ways, further progress in the field is heavily contingent on the feasibility, capacity, and efficiency of clinical trials to incorporate the rapidly evolving knowledge base and to provide substantive evidence for novel AF therapeutic strategies. This review outlines the current state of AF prevention and treatment trials, including the foreseeable challenges, as discussed by a unique forum of clinical trialists, scientists, and regulatory representatives in a session endorsed by the Heart Rhythm Society at the 12th Global CardioVascular Clinical Trialists Forum in Washington, DC, December 3–5, 2015

QPOs in Cataclysmic Variables and in X-ray Binaries

Recent observations, reported by Warner and Woudt, of Dwarf Nova Oscillations (DNOs) exhibiting frequency drift, period doubling, and 1:2:3 harmonic structure, can be understood as disc oscillations that are excited by perturbations at the spin frequency of the white dwarf or of its equatorial layers. Similar quasi-periodic disc oscillations in black hole low-mass X-ray binary (LMXB) transients in a 2:3 frequency ratio show no evidence of frequency drift and correspond to two separate modes of disc oscillation excited by an internal resonance. Just as no effects of general relativity play a role in white dwarf DNOs, no stellar surface or magnetic field effects need be invoked to explain the black hole QPOs.Comment: Revised version. Astronomy & Astrophysics (Letters), in pres

Juxtaposition of Chemical and Mutation-Induced Developmental Defects in Zebrafish Reveal a Copper-Chelating Activity for Kalihinol F

SummaryA major hurdle in using complex systems for drug screening is the difficulty of defining the mechanistic targets of small molecules. The zebrafish provides an excellent model system for juxtaposing developmental phenotypes with mechanism discovery using organism genetics. We carried out a phenotype-based screen of uncharacterized small molecules in zebrafish that produced a variety of chemically induced phenotypes with potential genetic parallels. Specifically, kalihinol F caused an undulated notochord, defects in pigment formation, hematopoiesis, and neural development. These phenotypes were strikingly similar to the zebrafish mutant, calamity, an established model of copper deficiency. Further studies into the mechanism of action of kalihinol F revealed a copper-chelating activity. Our data support this mechanism of action for kalihinol F and the utility of zebrafish as an effective system for identifying therapeutic and target pathways

Disc-oscillation resonance and neutron star QPOs: 3:2 epicyclic orbital model

The high-frequency quasi-periodic oscillations (HF QPOs) that appear in the X-ray fluxes of low-mass X-ray binaries remain an unexplained phenomenon. Among other ideas, it has been suggested that a non-linear resonance between two oscillation modes in an accretion disc orbiting either a black hole or a neutron star plays a role in exciting the observed modulation. Several possible resonances have been discussed. A particular model assumes resonances in which the disc-oscillation modes have the eigenfrequencies equal to the radial and vertical epicyclic frequencies of geodesic orbital motion. This model has been discussed for black hole microquasar sources as well as for a group of neutron star sources. Assuming several neutron (strange) star equations of state and Hartle-Thorne geometry of rotating stars, we briefly compare the frequencies expected from the model to those observed. Our comparison implies that the inferred neutron star radius "RNS" is larger than the related radius of the marginally stable circular orbit "rms" for nuclear matter equations of state and spin frequencies up to 800Hz. For the same range of spin and a strange star (MIT) equation of state, the inferrred radius RNS is roughly equal to rms. The Paczynski modulation mechanism considered within the model requires that RNS < rms. However, we find this condition to be fulfilled only for the strange matter equation of state, masses below one solar mass, and spin frequencies above 800Hz. This result most likely falsifies the postulation of the neutron star 3:2 resonant eigenfrequencies being equal to the frequencies of geodesic radial and vertical epicyclic modes. We suggest that the 3:2 epicyclic modes could stay among the possible choices only if a fairly non-geodesic accretion flow is assumed, or if a different modulation mechanism operates.Comment: 7 pages, 4 figures (in colour), accepted for publication in Astronomy & Astrophysic

Bounding the mass of the graviton using gravitional-wave observations of inspiralling compact binaries

If gravitation is propagated by a massive field, then the velocity of gravitational waves (gravitons) will depend upon their frequency and the effective Newtonian potential will have a Yukawa form. In the case of inspiralling compact binaries, gravitational waves emitted at low frequency early in the inspiral will travel slightly slower than those emitted at high frequency later, modifying the phase evolution of the observed inspiral gravitational waveform, similar to that caused by post-Newtonian corrections to quadrupole phasing. Matched filtering of the waveforms can bound such frequency-dependent variations in propagation speed, and thereby bound the graviton mass. The bound depends on the mass of the source and on noise characteristics of the detector, but is independent of the distance to the source, except for weak cosmological redshift effects. For observations of stellar-mass compact inspiral using ground-based interferometers of the LIGO/VIRGO type, the bound on the graviton Compton wavelength is of the order of $6 \times 10^{12}$ km, about double that from solar-system tests of Yukawa modifications of Newtonian gravity. For observations of super-massive black hole binary inspiral at cosmological distances using the proposed laser interferometer space antenna (LISA), the bound can be as large as $6 \times 10^{16}$ km. This is three orders of magnitude weaker than model-dependent bounds from galactic cluster dynamics.Comment: 8 pages, RevTeX, submitted to Phys. Rev.

A microquasar classification from a disk instability perspective

The spectacular variability of microquasars has led to a long string of efforts in order to classify their observed behaviors in a few states. The progress made in the understanding of the Quasi-Periodic Oscillations observed in these objects now makes it possible to develop a new way to find order in their behavior, based on the theorized physical processes associated with these oscillations. This will also have the interest of reuniting microquasars in a single classification based on the physical processes at work and therefore independent of their specificities (mass, variation timescale, outburst history, etc.). This classification is aimed to be a tool to further our understanding of microquasars behavior and not to replace phenomenological states. We start by considering three instabilities that can cause accretion in the disk. We compare the conditions for their development, and the Quasi-Periodic Oscillations they can be expected to produce, with the spectral states in which these Quasi-Periodic Oscillations are observed and sometimes coexist. From the three instabilities that we proposed to explain the three states of GRS 1915+105 we actually found the theoretical existence of four states. We compared those four states with observations and also how those four states can be seen in a model-independent fashion. Those four state can be used to find an order in microquasar observations, based on the properties of the Quasi-Periodic Oscillations and the physics of the associated instabilities.Comment: accepted by A&

Ariel - Volume 11 Number 1

Executive Editors Ellen Feldman Leonardo S. Nasca, Jr. Business Managers Barbara L. Davies Martin B. Getzow News Editor Aaron D. Bleznak Features Editor Dave Van Wagoner CAHS Editor Joan M. Greco Editorial Page Editor Samuel Markind Photography Editor Leonardo S. Nasca, Jr. Sports Editor Paul F. Mansfiel

Searching for periodic sources with LIGO. II: Hierarchical searches

The detection of quasi-periodic sources of gravitational waves requires the accumulation of signal-to-noise over long observation times. If not removed, Earth-motion induced Doppler modulations, and intrinsic variations of the gravitational-wave frequency make the signals impossible to detect. These effects can be corrected (removed) using a parameterized model for the frequency evolution. We compute the number of independent corrections $N_p(\Delta T,N)$ required for incoherent search strategies which use stacked power spectra---a demodulated time series is divided into $N$ segments of length $\Delta T$, each segment is FFTed, the power is computed, and the $N$ spectra are summed up. We estimate that the sensitivity of an all-sky search that uses incoherent stacks is a factor of 2--4 better than would be achieved using coherent Fourier transforms; incoherent methods are computationally efficient at exploring large parameter spaces. A two-stage hierarchical search which yields another 20--60% improvement in sensitivity in all-sky searches for old (>= 1000 yr) slow (= 40 yr) fast (<= 1000 Hz) pulsars. Assuming 10^{12} flops of effective computing power for data analysis, enhanced LIGO interferometers should be sensitive to: (i) Galactic core pulsars with gravitational ellipticities of \epsilon\agt5\times 10^{-6} at 200 Hz, (ii) Gravitational waves emitted by the unstable r-modes of newborn neutron stars out to distances of ~8 Mpc, and (iii) neutron stars in LMXB's with x-ray fluxes which exceed $2 \times 10^{-8} erg/(cm^2 s)$. Moreover, gravitational waves from the neutron star in Sco X-1 should be detectable is the interferometer is operated in a signal-recycled, narrow-band configuration.Comment: 22 Pages, 13 Figure