On The Timescale Forcing in Astrobiology

We investigate the effects of correlated global regulation mechanisms, especially Galactic gamma-ray bursts (GRBs), on the temporal distribution of hypothetical inhabited planets, using simple Monte Carlo numerical experiments. Starting with recently obtained models of planetary ages in the Galactic Habitable Zone (GHZ), we obtain that the times required for biological evolution on habitable planets of the Milky Way are highly correlated. These results run contrary to the famous anti-SETI anthropic argument of Carter, and give tentative support to the ongoing and future SETI observation projects.Comment: 6 pages, 4 figures, preliminary report, published in Serbian Astronomical Journal, vol. 175, 45-5

Performance modelling of the Cambridge Fast Ring protocol

The Cambridge Fast Ring is high-speed slotted ring. The features that make it suitable for use at very large transmission rates are the synchronous transmission, the simplicity of the medium-access-control protocol, and the possibility of immediate retransmission of erroneous packets. A novel analytical model of the Cambridge Fast Ring with normal slots is presented. The model is shown to be accurate and usable over wide range of parameters. A performance analysis based on this model is presented

Analysing I/O bottlenecks in LHC data analysis on grid storage resources

We describe recent I/O testing frameworks that we have developed and applied within the UK GridPP Collaboration, the ATLAS experiment and the DPM team, for a variety of distinct purposes. These include benchmarking vendor supplied storage products, discovering scaling limits of SRM solutions, tuning of storage systems for experiment data analysis, evaluating file access protocols, and exploring I/O read patterns of experiment software and their underlying event data models. With multiple grid sites now dealing with petabytes of data, such studies are becoming essential. We describe how the tests build, and improve, on previous work and contrast how the use-cases differ. We also detail the results obtained and the implications for storage hardware, middleware and experiment software

Evaluation of Rope Shovel Operators in Surface Coal Mining Using a Multi-Attribute Decision-Making Model

Rope shovels are used to dig and load material in surface mines. One of the main factors that influence the productivity and energy consumption of rope shovels is the performance of the operator. Existing methods of evaluating operator performance do not consider the relationship between production rate and energy consumption. This thesis presents a method for evaluating rope shovel operators using the Multi-Attribute Decision-Making (MADM) model. Data used in this research were collected from an operating surface coal mine in the southern United States. The MADM model used in this research consists of attributes, their weights of importance, and alternatives. Shovel operators are considered the alternatives in the MADM model. The energy consumption model was developed with multiple regression analysis, and its variables are included in the MADM model as attributes. Formulation of the production rate model is already known, and thus determining the attributes that have a significant influence is straightforward. Preferences with respect to min/max of the defined attributes were obtained with multi-objective optimization. Multi-objective optimization was performed with the overall goal of minimizing energy consumption and maximizing production rate. Weights of importance of the attributes were determined by using the Analytical Hierarchy Process (AHP). The overall evaluation of operators was performed by using one of the MADM models, PROMETHEE II. The research presented here may be used by mining professionals to help evaluate the performance of rope shovel operators in surface mining

Waiting time estimates in symmetric ATM-oriented rings with the destination release of used slots

This paper considers the basic access mechanism in asynchronous transfer mode (ATM)-oriented rings which, like Orwell, ATM ring, and ALine, apply destination release of used slots. The released slots may be reused by the destination station, or in some protocols, they must be given to the next station. Such a mechanism can be modeled by a multiple-server multiqueue system, where switchover times between consecutive polling instants of the queues are nonzero. The server polls the queues according to a certain polling discipline, which is dependent on the service time. This paper presents approximate mean minipacket waiting times in such systems. The approximation is based on a polling queueing model with Markovian server routing. Poisson arrivals and a symmetric workload model for minipackets having a full and partial traffic matrix are assumed. The performance characteristics are compared between the alternative option

Increase of ribavirin dose improves sustained virological response in HCV-genotype 1 patients with a partial response to peg-interferon and ribavirin

Background and aim. In patients with chronic hepatitis C receiving Peg interferon/ribavirin (PEG-IFN/RBV) who do not achieve ≥ 2log-reduction in HCV-RNA at week 12 (null responders, NR) and in those with ≥ 2log-decrease but detectable at week 24 (partial responders, PR) the probability to achieve the sustained virological response (SVR) is almost null. The aim of this study was to investigate the efficacy of individualized schedule of progressively increased RBV doses in the setting of PEG-IFN/RBV treatment. Material and methods. PR or NR to PEG-IFN/RBV instead of discontinuing treatment were enrolled to receive increasing doses of RBV until a target theoretical concentration ([tRBV]) of ≥ 15 μmol/L (by pharmacokinetic formula based on glomerular filtration rate). HCV-RNA was assessed every 4 weeks and, if detectable, RBV dose was gradually increased until negativization. Twelve weeks later, patients with detectable HCV-RNA discontinued therapy while those with undetectable HCV-RNA continued for further 48 weeks. Results. Twenty genotype-1 patients (8 NR and 12 PR) were enrolled. After 12 weeks 9 (45%) were still HCV-RNA positive and were discontinued, while remaining 11 had undetectable HCV-RNA. One stopped treatment for side effects. Ten completed treatment. Five (all PR) achieved SVR. Side effects incidence was similar to that observed during PEG-IFN/RBV. Conclusions. In conclusion, RBV high doses, according to individualized schedule, increase SVR in PR on a similar extent to that of triple therapy but without increase of side effects. Such treatment should be considered in PR with no access or intolerant to protease inhibitors (PI)