Akuntabilitas Pengelolaan Dana Desa Kabupaten Bantul

This study was conducted to examine the effect of accessibility of financial statements, internal control system, organizational commitment, competence of village officials, and the role of village officials on village fund management accountability. This research was conducted in five Kapanewon, Bantul Regency, totaling 29 Kalurahan. The research sample amounted to 101 respondents where the sampling technique used purposive sampling. The research method used is quantitative research with technical data analysis in the form of multiple linear regression where the hypothesis test uses a significance level of = 0.05 with the help of SPSS version 26.0. The results of this study indicate that the accessibility of financial reports, internal control systems, organizational commitment, competence of village officials, and the role of village officials affect the accountability of village fund management

Akuntabilitas Pengelolaan Dana Desa Kabupaten Bantul

This study was conducted to examine the effect of accessibility of financial statements, internal control system, organizational commitment, competence of village officials, and the role of village officials on village fund management accountability. This research was conducted in five Kapanewon, Bantul Regency, totaling 29 Kalurahan. The research sample amounted to 101 respondents where the sampling technique used purposive sampling. The research method used is quantitative research with technical data analysis in the form of multiple linear regression where the hypothesis test uses a significance level of = 0.05 with the help of SPSS version 26.0. The results of this study indicate that the accessibility of financial reports, internal control systems, organizational commitment, competence of village officials, and the role of village officials affect the accountability of village fund management

Modeling population dynamics of Anoda cristata in a glyphosate-resistant soybean crop under different management systems

ABSTRACT A computer simulation model was developed to describe Anoda cristata (L.) Schlecht seedbank dynamics in soybeans. The model considers different weed management strategies: absence of control, control with the recommended rate and with glyphosate at half the recommended rate, and two soybean row spacings (35 and 70 cm). The model was evaluated using data from previous experiments obtained for four consecutive years. The model accurately reproduced the seedbank dynamics. The seedbank decreased more in weed management strategies without seed production. In absence of control, the seedbank reached an equilibrium density. When seeds were produced every year, the model output was more sensitive to changes in the rate of predation; but without seed production, seed mortality was the most important process. Simulation demonstrated that long-term eradication may occur with continuous use of glyphosate at the recommended rate or with the combination of soybean at 35 cm between rows and glyphosate at half the recommended rate

Prognostic Significance and Gene Expression Profiles of p53 Mutations in Microsatellite-Stable Stage III Colorectal Adenocarcinomas

Although the prognostic value of p53 abnormalities in Stage III microsatellite stable (MSS) colorectal cancers (CRCs) is known, the gene expression profiles specific to the p53 status in the MSS background are not known. Therefore, the current investigation has focused on identification and validation of the gene expression profiles associated with p53 mutant phenotypes in MSS Stage III CRCs. Genomic DNA extracted from 135 formalin-fixed paraffin-embedded tissues, was analyzed for microsatellite instability (MSI) and p53 mutations. Further, mRNA samples extracted from five p53-mutant and five p53-wild-type MSS-CRC snap-frozen tissues were profiled for differential gene expression by Affymetrix Human Genome U133 Plus 2.0 arrays. Differentially expressed genes were further validated by the high-throughput quantitative nuclease protection assay (qNPA), and confirmed by quantitative real-time polymerase chain reaction (qRT-PCR) and by immunohistochemistry (IHC). Survival rates were estimated by Kaplan-Meier and Cox regression analyses. A higher incidence of p53 mutations was found in MSS (58%) than in MSI (30%) phenotypes. Both univariate (log-rank, P = 0.025) and multivariate (hazard ratio, 2.52; 95% confidence interval, 1.25–5.08) analyses have demonstrated that patients with MSS-p53 mutant phenotypes had poor CRC-specific survival when compared to MSS-p53 wild-type phenotypes. Gene expression analyses identified 84 differentially expressed genes. Of 49 down-regulated genes, LPAR6, PDLIM3, and PLAT, and, of 35 up-regulated genes, TRIM29, FUT3, IQGAP3, and SLC6A8 were confirmed by qNPA, qRT-PCR, and IHC platforms. p53 mutations are associated with poor survival of patients with Stage III MSS CRCs and p53-mutant and wild-type phenotypes have distinct gene expression profiles that might be helpful in identifying aggressive subsets