13 research outputs found
Vaccinia-related kinase 2
No full textVRK2 is a Ser-Thr kinase and has two isoforms, cytosolic and nuclear. The full-length VRK2 cyto-solic isoform (A) inhibits MAPK signaling by a direct interaction with the corresponding JIP1 or KSR1 scaffold proteins. As a consequence high levels of VRK2A inhibits in a dose dependent manner signals mediated by the TAK1-MKK7-JNK in response to hypoxia or interleukin, and the signal of the ERBB2-RAS-RAF-MEK-ERK pathway. Downregulation of VRK2A relieves this inhibition and allows signal transmission in response to stimuli initiated in Receptor-tyrosine kinases (RTK), such as ERBB2. Thus, in breast cancer, VRK2A and ERBB2 present an inverse correlation. VRK2 controls protein quality by regulating degradation of misfolded proteins. Mitochondrial VRK2 controls the association of
Bax to mitochondrial membranes and thus modulates apoptosis. Allelic noncoding polymorphisms of the VRK2 gene have been linked to several neurological diseases.Peer Reviewe
VRK2
No full textVRK2 is a Ser-Thr kinase and has two isoforms, cytosolic and nuclear. The full-length VRK2 cytosolic isoform (A) inhibits MAPK signaling by a direct interaction with the corresponding JIP1 or KSR1 scaffold proteins. As a consequence, high levels of VRK2A inhibit in a dose-dependent manner signals mediated by the TAK1-MKK7-JNK in response to hypoxia or interleukin, and the signal of the ERBB2-RAS-RAF-MEK-ERK pathway. Downregulation of VRK2A relieves this inhibition and allows signal transmission in response to stimuli initiated in receptor-tyrosine kinases (RTK), such as ERBB2. Thus, in breast cancer VRK2A and ERBB2 present an inverse correlation.Peer Reviewe
Human VRK2 modulates apoptosis by interaction with Bcl-xL and regulation of BAX gene expression
No full textSensitivity of the kinase activity of human vaccinia-related kinase proteins to toxic metals
No full textNFAT1 Is Highly Expressed in, and Regulates the Invasion of, Glioblastoma Multiforme Cells
No full textVaccinia-related kinase 2 blunts sorafenib’s efficacy against hepatocellular carcinoma by disturbing the apoptosis-autophagy balance
No full textVRK1 phosphorylates and protects NBS1 from ubiquitination and proteasomal degradation in response to DNA damage
No full textOncogenic Sox2 regulates and cooperates with VRK1 in cell cycle progression and differentiation
No full textVRK2 anchors KSR1-MEK1 to endoplasmic reticulum forming a macromolecular complex that compartmentalizes MAPK signaling
No full textVRK1 regulates Cajal body dynamics and protects coilin from proteasomal degradation in cell cycle
No full text
