Sagittal spinal curvatures and pelvic inclination in kayakers

El objetivo del estudio fue comparar la disposición sagital del raquis e inclinación pélvica en diferentes posiciones en kayakistas. A ciento treinta kayakistas entre 15 y 20 años (62 varones y 68 mujeres) se les evaluó, mediante un Spinal Mouse, la disposición angular del raquis torácico, lumbar e inclinación pélvica en bipedestación, sedentación relajada, máxima flexión del tronco en sedentación, test sit-and-reach, posición de base y de ataque en un kayak-ergómetro. La cifosis torácica en la piragua fue menor (p<0,001) que en bipedestación y sedentación relajada. El raquis lumbar se dispuso en inversión lumbar en las posturas de flexión del tronco y sedentación, favorecido por una posición de retroversión pélvica. Las mujeres adoptaron posturas de menor flexión lumbar y pélvica en el kayak-ergómetro. En conclusión, la posición de las mujeres en el kayak-ergómetro se caracteriza por posturas más alineadas del raquis y pelvisThe aim of this study was to compare the sagittal spinal curvatures and pelvic tilt in different positions on kayakers. One hundred and thirty kayakers between 15 and 20 years (62 males and 68 females) participated in this study. Thoracic and lumbar curvatures and pelvic position were evaluated with a Spinal Mouse system in standing position, slumped sitting, maximal trunk bending with knees flexed, sit-and-reach test, base position right entry position and left entry position in a kayak ergometer. Thoracic kyphosis in the kayak-ergometer was more reduced (p<0,001) than standing and slumped sitting. Lumbar spine adopted kyphotic postures when maximal trunk flexion was performed and in the kayak ergometer. This posture was related to posterior pelvic tilt. Females showed lower lumbar and pelvic flexion than males in the kayak ergometer. In conclusion, females adopt more aligned spinal and pelvic postures in the kayak ergometer than malesEste estudio se realizó en el marco de las ayudas de la Fundación Séneca-Agencia de Ciencia y Tecnología de la Región de Murcia (II PCTRM 2007-2010) al proyecto nº 11951/PI/09, titulado “Evolution of sagittal spinal curvatures, hamstring extensibility, low back pain, and anthropometric characteristics in elite paddlers

Effect of different interpolation methods on the accuracy of the reconstruction of spiral k-space trajectories in MRI

[Poster] 4th European Molecular Imaging Meeting, Barcelona, Spain, May 27 - 30, 2009This work is supported in part by the projects CdTeaM (CeniT-ingenio 2010), Ministerio de Ciencia e innovación, and Ciber Cb07/09/0031 CiberSaM, Ministerio de Sanidad y Consumo.Publicad

Traumatic brain injury: Failure of the intravenous route for the administration of bone marrow stromal stem cells as treatment of chronic neurological sequels

Objetivo: Estudiar el posible efecto terapéutico de la administración intravenosa de células madre estromales (CME) obtenidas de médula ósea para tratar las secuelas neurológicas en fase crónica tras una lesión cerebral traumática. Material y método: Se realizó un modelo de lesión cerebral traumática en ratas Wistar adultas y se estudió el déficit neurológico inducido en el curso de los dos meses siguientes, por medio del test mNSS y el test Smart. Tras ese tiempo, en fase de secuelas crónicamente establecidas, se administraron intravenosamente 15 x 106 CME (n:10) o suero fisiológico (n:10). En los dos meses siguientes se estudió la posible modificación de las secuelas neurológicas. Resultados: Cuando se compararon los resultados de la valoración funcional entre ambos grupos experimentales, no se observaron diferencias estadísticamente significativas. Conclusión: Nuestros resultados sugieren que el trasplante de CME por vía intravenosa, en una fase de secuelas crónicamente establecidas tras una lesión traumática cerebral grave, no tiene efecto terapéuticoObjective: We studied the possible therapeutic effect of intravenous administration (noninvasive method) of BMSCs to treat neurological sequels in a chronic stage after TBI. Material and method: A model of TBI in adult Wistar rats was performed and we studied the neurological deficit induced in the course of two months, through the mNSS and Smart tests. After this time, with established sequels, 15 x 106 BMSCs (n = 10) or saline (n = 10) were administered intravenously. Changes in the neurological deficits were studied in two months. Results: Comparison of functional changes between both experimental groups showed no statistically significant differences. Conclusions: Our results suggest that transplantation of BMSCs intravenously, at a stage of established sequels after severe TBI, has no therapeutic effectEsta investigación ha sido financiada por FUNDACIÓN MAPFR

Reduction of respiratory blurring in small-animal CT scans based on a fast retrospective gating method

[Abstract] The 22nd International Congress and Exhibition, Barcelona, Spain, June 25-28, 2008The purpose of the present work was to develop a fast retrospective method to extract the respiratory signal from the CT projections in cone beam geometry and to obtain dynamic breathing studies in small animal scans. The whole process had to be software-based and automatic, avoiding the use of any additional respiratory gating instrumentsPublicad

Quantitative comparison of partial fourier reconstruction algorithms in MRI at 7T

[Poster] 4th European Molecular Imaging Meeting, Barcelona, Spain, May 27 - 30, 2009In this work we present a quantitative comparison at 7T of the most common partial fourier reconstruction algorithms: conjugate synthesis with phase correction, Margosian method, homodyne reconstruction, PoCS algorithm and iterative homodyne reconstructionThis work is supported in part by the projects CdTeaM (CeniT-ingenio 2010), Ministerio de Ciencia e innovación, and Ciber Cb07/09/0031 CiberSaM, Ministerio de Sanidad y Consumo.Publicad

Validation of a restrospective respiratory gating method for small-animal CT scanners

Proceeding of: 2008 IEEE Nuclear Science Symposium Conference Record (NSS '08), Dresden, Germany, 19-25 October 2008We propose a retrospective respiratory gating algorithm to generate dynamic CT studies. To this end, we compared three different methods of extracting the respiratory signal from the projections of small-animal cone-beam computed tomography (CBCT) scanners. Given a set of frames acquired from a certain axial angle, subtraction of their average image from each individual frame produces a set of difference images. The respiratory signals were extracted by analyzing the shape of the histogram of these difference images: we calculated the first four central and non-central moments. However, only odd-order moments produced the desired breathing signal, as the even-order moments lacked information about the phase. Each of these curves was compared to a reference signal recorded by means of a pneumatic pillow. Given the similar correlation coefficients yielded by all of them, we selected the mean to implement our retrospective protocol. Respiratory phase bins were separated, reconstructed independently and included in a dynamic sequence, suitable for cine playback. We validated our method in 5 adult rat studies by comparing profiles drawn across the diaphragm dome, with and without retrospective respiratory gating. Results showed a sharper transition in the gated reconstruction, with an average slope improvement of 60.7%.This project was supported by the CENIT Programme (Ministerio de Industria), CIBER CB07/09/0031 and RETICRECAVA (Ministerio de Sanidad y Consumo), and TEC2007-64731 TCM (Ministerio de Educaci6n y Ciencia)

The role of ketamine in major depressive disorders: Effects on parvalbumin-positive interneurons in hippocampus

Major depressive disorder (MDD) is a complex illness that is arising as a growing public health concern. Although several brain areas are related to this type of disorders, at the cellular level, the parvalbumin-positive cells of the hippocampus interplay a very relevant role. They control pyramidal cell bursts, neuronal networks, basic microcircuit functions, and other complex neuronal tasks involved in mood disorders. In resistant depressions, the efficacy of current antidepressant treatments drops dramatically, so the new rapid-acting antidepressants (RAADs) are being postulated as novel treatments. Ketamine at subanesthetic doses and its derivative metabolites have been proposed as RAADs due to their rapid and sustained action by blocking N-methyl-d-aspartate (NMDA) receptors, which in turn lead to the release of brain-derived neurotrophic factor (BDNF). This mechanism produces a rapid plasticity activation mediated by neurotransmitter homeostasis, synapse recovery, and increased dendritic spines and therefore, it is a promising therapeutic approach to improve cognitive symptoms in MDD.Fil: Barrutieta Arberas, I.. Universidad del País Vasco; EspañaFil: Ortuzar, N.. Universidad del País Vasco; EspañaFil: Vaquero Rodríguez, A.. Universidad del País Vasco; EspañaFil: Picó-Gallardo, M.. Universidad del País Vasco; EspañaFil: Bengoetxea, H.. Universidad del País Vasco; EspañaFil: Guevara, M. A.. Universidad Nacional de Cuyo; ArgentinaFil: Gargiulo, Pascual Angel. Universidad Nacional de Cuyo; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza; ArgentinaFil: Lafuente, J. V.. Universidad del País Vasco; Españ

Quantification of SPIO using T2* and phase imaging

Proceeding of: 17th Scientific Meeting, International Society for Magnetic Resonance in Medicine, 18-24 April, 2009, Honolulu, Hawai, USAPublicad