Holistic optimization of HVAC systems via distributed data-driven control

In the present paper, the control design of Heating, Ventilation and Air Conditioning (HVAC) systems is investigated. In largescale buildings – e.g. hotels or hospitals – the high dimension of the control design problem precludes a solution with reasonable computational effort. In this paper, a distributed control strategy is proposed, where interacting agents are operating sub-systems; interaction between these agents can ensure that an optimum solution can be obtained. A novel method to distributed control tis introduced based on data-driven modeling where the strategy is not based on explicit optimization, but on weighted learning of the control rules; two examples of the addressed system are formulated. A significant advantage of the proposed approach consists in minimal assumptions on the addressed system and the most significant disadvantage is the need of sufficiently rich data-sets

Study of two MTA cements

Introduction: To determine and compare the pH, conductivity and calcium release of an experimental Portland cement (PE) consisting of trioxid mineral aggregate and a comercially available modified Portland cement (C.P.M.) after 1, 2, 3, 4, 8, 10, 15 and 30 days. Material and Methods: Cements were mixed following the manufacturer's instructions, with a powder: liquid ratio of 3:1. Each cement was placed in 12 PVC tubes 1 mm in diameter and 10 mm in length and allowed to set. Four empty tubes were used as negative controls. Tubes were submerged in plastic flasks containing 10 ml deionized water and stored at 37ºC and 100% humidity. After 1, 2, 3, 4, 8, 10, 15 and 30 days tubes were removed from the flasks and these were refilled with deionized water. We measured pH, conductivity and calcium content of the recovered solution. Data were analyzed using repeated measures ANOVA. Results: pH was 0.3 units more alkaline with PE cement (p=0.023). pH experienced a slight decrease with time (p0.05). Conductivity of PE and CPM cements diminished at 4 days and almost recovered at 30 days (p0.05). Conclusions: PE cement raised pH slightly more and had higher conductivity than CPM. Calcium release diminished after the first day and recovered at 30 days, similarly for both cements

Evaluation of the inflammatory and osteogenic response induced by titanium particles released during implantoplasty of dental implants

Implantoplasty is a mechanical decontamination technique that consists of removing the threads and polishing and smoothing the dental implant surface. During implantoplasty there is a large release of titanium metal particles that might provoke a proinflammatory response and reduce the viability of osteogenic cells. We analyze the inflammatory and osteogenic response induced by Ti6Al4V particles released during implantoplasty and by as-received commercially pure Ti particles. Macrophages stimulated with metal particles obtained by implantoplasty and with as-received Ti particles showed an increased proinflammatory expression of TNF-alpha and a decreased expression of TGF-beta and CD206. Regarding cytokine release, there was an increase in IL-1 beta, while IL-10 decreased. The osteogenic response of Ti6Al4V extracts showed a significant decrease in Runx2 and OC expression compared to the controls and commercially pure Ti extracts. There were no relevant changes in ALP activity. Thus, implantoplasty releases metal particles that seems to induce a pro-inflammatory response and reduce the expression of osteogenic markers

Revisió ràpida de la literatura sobre l’impacte de les intervencions per millorar el benestar/salut emocional en la salut mental de la població des d’atenció primària i comunitària

Benestar emocional; Salut mental; Atenció primària i comunitàriaBienestar emocional; Salud mental; Atención primaria y comunitariaEmotional well-being; Mental health; Primary and community health careL’objectiu del present informe és determinar l’evidència sobre l’impacte de les intervencions de benestar emocional adreçats a la població general des de l’àmbit APiC en la salut mental de la població. Com a objectius secundaris, s’ha proposat descriure rols similars al del/la RBEC, l’evidència d’aquests en la millora del benestar emocional en els pacients segons la literatura i els indicadors/variables de resultat que es mesuren en aquestes intervencions (destacant els de programes adreçats a millorar el benestar emocional des de l’APiC)

Revista de Revistas.

Selección de reseñas bibliográficas. (Octubre, Noviembre y Diciembre, 1991) Trastornos de la personalidad bordeline. Epidemiología (Thomas A. Widiger, Mima M. Weissman), Assessement y Diagnosis (Andrew E. Skodol y John M. Oldhan), Biological y Pharmacological Aspects (Emil F Coceara, Richard J. KavonssJ), Standarized Appraaches to individual Psychoterapy (M. Tracy Shea) y Graup y Family Tretments (Jons F Clarkin y EIsa MarzialJ) Hospital and community Psychiatry. Octuber 1991; 42 (10): 1015-1043 . M García Pérez La dopamina en la esquizofrenia: una revisión y reconceptualización Dopamine in schizophrenia: A review and reconceptualization. Kenneth L. Davis, MD, Rene S. Kahn, Mo., Grant Ka. MD, MichaelDavidson, Mo. (Del Departamento de Psiquiatría del Hospital y Escuela de Medicina de Mount Sinai, NY) AM J Psychiatry. 1991; Nov, 148: 1474-1486. M García Pérez La controversia Freud-Ferenczi. Un legado viviente. The Freud-Ferenczi controversy. A living legacy. Axel Hoffer, Brookline, Massachusetts. The International Review of Psychoanalysis. Int. Rev. Psycho-Anal. 1991; 18 (4): 465-472. A. E. Nafs Revisión de los conocimientos del Autismo Psicógeno. Revised understandings of Psychogenic Autism. Frances Tustin, Londres. The International Journal of Psycho-Analysis. Int. J. Psycho-Anal 1991; 72 (4): 585-591. A. E. Nafs Dementia of Depresion in Parkinson's Disease and Stroke. Starkstein S.E., Robinson R.G. Journal of Nervous and Mental Disease. 1991 (octubre); 179: 593-601 M. Catalina Zamora An interactionistic integrative view of depresive disordes and their tretment. C. Perris. Departamento de Psiquiátrica y colaborador del Centro de Enseñanza e Investigador de enfermedades Mentales. Universidad de Umea. Suecia Acta Psychiartr. Scand 1991; 84: 413-423E. García Yagüe Personalidad premórbida y síntomas positivos y negativos en la esquizofrenia. V. Peralta y M.J. Cuesta. Unidad de Psiquiatría del Hospital Virgen del Camino. Pamplona. España. J. Delean. Instituto Psiquiátrico de Pensilvania U.S.A. Acta Psychiatr. Scand. 1991; 84: 336-339. E. García Yagüe Interacción entre vulnerabilidad genética y ambiente familiar: estudio finlandés de familias adoptivas en la esquizofrenia. P Teinavi. Departamento Psychiatry. Acta Psychiatr. Scand 1991; 84: 460-465 E. García Yagüe Factores de estrés y enfermedad. J.L. González Rivera. Actas Luso-Esp. Neurol. Psiquiatr. 1991 (Nov-Dic); 19 (6): 290-297. J. García-Noblejas Los orígenes de la psicosis y el «origen del hombre». The origins of psychosis and "the descent of man". T.J. Crow British Journal of Psychiatry. 1991; 159 (sup. 14): 76-82 M.I. de la Hera Cabero. Hallazgos clínicos. Trastornos del estado mental y del movimiento y sus secuelas. Clínical findings. Abnormalities of the mental state and movement disorder and their correlates. Eve C. Johnstone, o.G.C. Owens, c.o. Frith and J. Leary British Journal of Psychatry 1991; 159 (supl. 13): 21-25. M.I. de la Hera Cabero Una perspectiva psicobiológica en los trastornos de la personalidad. A psycobiological perspective on the personality disorders. L.J. Siever, K. L. Davis AM. J. Psychiatry 12, Diciembre 1991; 148: 1647-1658. c. Herraez Martín de Valmaseda El estado de la cuestión en... Manifestaciones psiquiátricas en enfermos con lupus eritematosos sistémico. Salvador Robert M., Pérez Sales P.., Rubio Valladolid G

Revista de Revistas.

Selección de reseñas bibliográficas. (Octubre, Noviembre y Diciembre, 1991) Trastornos de la personalidad bordeline. Epidemiología (Thomas A. Widiger, Mima M. Weissman), Assessement y Diagnosis (Andrew E. Skodol y John M. Oldhan), Biological y Pharmacological Aspects (Emil F Coceara, Richard J. KavonssJ), Standarized Appraaches to individual Psychoterapy (M. Tracy Shea) y Graup y Family Tretments (Jons F Clarkin y EIsa MarzialJ) Hospital and community Psychiatry. Octuber 1991; 42 (10): 1015-1043 . M García Pérez La dopamina en la esquizofrenia: una revisión y reconceptualización Dopamine in schizophrenia: A review and reconceptualization. Kenneth L. Davis, MD, Rene S. Kahn, Mo., Grant Ka. MD, MichaelDavidson, Mo. (Del Departamento de Psiquiatría del Hospital y Escuela de Medicina de Mount Sinai, NY) AM J Psychiatry. 1991; Nov, 148: 1474-1486. M García Pérez La controversia Freud-Ferenczi. Un legado viviente. The Freud-Ferenczi controversy. A living legacy. Axel Hoffer, Brookline, Massachusetts. The International Review of Psychoanalysis. Int. Rev. Psycho-Anal. 1991; 18 (4): 465-472. A. E. Nafs Revisión de los conocimientos del Autismo Psicógeno. Revised understandings of Psychogenic Autism. Frances Tustin, Londres. The International Journal of Psycho-Analysis. Int. J. Psycho-Anal 1991; 72 (4): 585-591. A. E. Nafs Dementia of Depresion in Parkinson's Disease and Stroke. Starkstein S.E., Robinson R.G. Journal of Nervous and Mental Disease. 1991 (octubre); 179: 593-601 M. Catalina Zamora An interactionistic integrative view of depresive disordes and their tretment. C. Perris. Departamento de Psiquiátrica y colaborador del Centro de Enseñanza e Investigador de enfermedades Mentales. Universidad de Umea. Suecia Acta Psychiartr. Scand 1991; 84: 413-423E. García Yagüe Personalidad premórbida y síntomas positivos y negativos en la esquizofrenia. V. Peralta y M.J. Cuesta. Unidad de Psiquiatría del Hospital Virgen del Camino. Pamplona. España. J. Delean. Instituto Psiquiátrico de Pensilvania U.S.A. Acta Psychiatr. Scand. 1991; 84: 336-339. E. García Yagüe Interacción entre vulnerabilidad genética y ambiente familiar: estudio finlandés de familias adoptivas en la esquizofrenia. P Teinavi. Departamento Psychiatry. Acta Psychiatr. Scand 1991; 84: 460-465 E. García Yagüe Factores de estrés y enfermedad. J.L. González Rivera. Actas Luso-Esp. Neurol. Psiquiatr. 1991 (Nov-Dic); 19 (6): 290-297. J. García-Noblejas Los orígenes de la psicosis y el «origen del hombre». The origins of psychosis and "the descent of man". T.J. Crow British Journal of Psychiatry. 1991; 159 (sup. 14): 76-82 M.I. de la Hera Cabero. Hallazgos clínicos. Trastornos del estado mental y del movimiento y sus secuelas. Clínical findings. Abnormalities of the mental state and movement disorder and their correlates. Eve C. Johnstone, o.G.C. Owens, c.o. Frith and J. Leary British Journal of Psychatry 1991; 159 (supl. 13): 21-25. M.I. de la Hera Cabero Una perspectiva psicobiológica en los trastornos de la personalidad. A psycobiological perspective on the personality disorders. L.J. Siever, K. L. Davis AM. J. Psychiatry 12, Diciembre 1991; 148: 1647-1658. c. Herraez Martín de Valmaseda El estado de la cuestión en... Manifestaciones psiquiátricas en enfermos con lupus eritematosos sistémico. Salvador Robert M., Pérez Sales P.., Rubio Valladolid G

RTS,S/AS01E immunization increases antibody responses to vaccine-unrelated Plasmodium falciparum antigens associated with protection against clinical malaria in African children:a case-control study

BACKGROUND: Vaccination and naturally acquired immunity against microbial pathogens may have complex interactions that influence disease outcomes. To date, only vaccine-specific immune responses have routinely been investigated in malaria vaccine trials conducted in endemic areas. We hypothesized that RTS,S/A01E immunization affects acquisition of antibodies to Plasmodium falciparum antigens not included in the vaccine and that such responses have an impact on overall malaria protective immunity. METHODS: We evaluated IgM and IgG responses to 38 P. falciparum proteins putatively involved in naturally acquired immunity to malaria in 195 young children participating in a case-control study nested within the African phase 3 clinical trial of RTS,S/AS01E (MAL055 NCT00866619) in two sites of different transmission intensity (Kintampo high and Manhiça moderate/low). We measured antibody levels by quantitative suspension array technology and applied regression models, multimarker analysis, and machine learning techniques to analyze factors affecting their levels and correlates of protection. RESULTS: RTS,S/AS01E immunization decreased antibody responses to parasite antigens considered as markers of exposure (MSP142, AMA1) and levels correlated with risk of clinical malaria over 1-year follow-up. In addition, we show for the first time that RTS,S vaccination increased IgG levels to a specific group of pre-erythrocytic and blood-stage antigens (MSP5, MSP1 block 2, RH4.2, EBA140, and SSP2/TRAP) which levels correlated with protection against clinical malaria (odds ratio [95% confidence interval] 0.53 [0.3-0.93], p = 0.03, for MSP1; 0.52 [0.26-0.98], p = 0.05, for SSP2) in multivariable logistic regression analyses. CONCLUSIONS: Increased antibody responses to specific P. falciparum antigens in subjects immunized with this partially efficacious vaccine upon natural infection may contribute to overall protective immunity against malaria. Inclusion of such antigens in multivalent constructs could result in more efficacious second-generation multistage vaccines