Use of etiotropic and pathogenetic medicines for COVID-19 in patients with renal failure and/or on dialysis

Impaired kidney function may influence pharmacokinetics of most of the drugs, including the ones used in COVID-19. In this publication, the most important pharmacokinetic parameters and dose adjustment approaches are provided, based on The Renal Drug Handbook и Sanford Guide. In the majority of cases, mild kidney function reduction does not necessitate dose adjustment. Each case should be considered individually, measuring benefits against risks

Possibility to use barycytinib in patients with COVID-19, including for treatment of «cytokine storm»

Until clinical trials of efficacy and safety are obtained, routine use of barycytinib in patients with COVID-19 cannot be recommended

Rationality of routine clinical use of olokizumab in COVID-19

Routine clinical use of olokizumab in COVID-19 is not recommended. The use of olokizumab is possible in clinical trials

Assessment Of the Knowledge of Theoretical Basis of Punching Technique of Army Hand-To-Hand Combat by Students at The Initial Stage of Training

The article presents the results of knowledge of the theoretical foundations of the attacking technique of army hand-to-hand combat at the initial stage of training. Methodology. The pedagogical experiment was carried out with the participation of 24 RTU MIREA students. Results. With the help of specially developed questionnaires, it was revealed that as a result of the implementation of the experimental methodology for teaching the technique of attacking actions of army hand-to-hand combat, taking into account the general and specific in its content, there was a significant increase in the level of knowledge among the students of the experimental group. Conclusions. The obtained results of the study confirm the expediency of using active forms (problem learning) as a means of teaching the technique of army hand-to-hand combat, taking into account the general and specific in its content among students of the RTU MIREA university

A CALCULATION OF SEMI-EMPIRICAL ONE-ELECTRON WAVE FUNCTIONS FOR MULTI-ELECTRON ATOMS USED FOR ELEMENTARY PROCESS SIMULATION IN NONLOCAL PLASMA

Subject of Research. The paper deals with development outcomes for creation method of one-electron wave functions of complex atoms, relatively simple, symmetrical for all atom electrons and free from hard computations. The accuracy and resource intensity of the approach are focused on systematic calculations of cross sections and rate constants of elementary processes of inelastic collisions of atoms or molecules with electrons (ionization, excitation, excitation transfer, and others). Method. The method is based on a set of two iterative processes. At the first iteration step the Schrödinger equation was solved numerically for the radial parts of the electron wave functions in the potential of the atomic core self-consistent field. At the second iteration step the new approximationfor the atomic core field is created that uses found solutions for all one-electron wave functions. The solution optimization for described multiparameter problem is achieved by the use of genetic algorithm. The suitability of the developed method was verified by comparing the calculation results with numerous data on the energies of atoms in the ground and excited states. Main Results. We have created the run-time version of the program for creation of sets of one-electron wave functions and calculation of the cross sections and constants of collisional transition rates in the first Born approximation. The priori available information about binding energies of the electrons for any many-particle system for creation of semi-empirical refined solutions for the one-electron wave functions can be considered at any step of this procedure. Practical Relevance. The proposed solution enables a simple and rapid preparation of input data for the numerical simulation of nonlocal gas discharge plasma. The approach is focused on the calculation of discharges in complex gas mixtures requiring inclusion in the model of a large number of elementary collisional and radiation processes involving heavy particles in different quantum states

Radiatively driven hypersonic wind tunnel

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/76604/1/AIAA-12568-479.pd

Effective organic matter stock management in agricultural practices: modeling and observation

Long-term fertilization experiments (LTFE), with the focus on analyzing soil fertility indicators and their interrelation with crop have fundamental importance for monitoring, modeling, and controlling the status of soils. Validation datasets from LTFE provide the basis for understanding cropland responses to key natural and management drivers such as climate and productivity, land use changes, soil fertility and greenhouse gas emissions. RothC model was used for simulation soil organic carbon (SOC) stocks in several Russian LTFE with mineral and organic fertilization. RothC was able to adequately simulate long-term SOC stock changes in the arable layer of different treatments of fertilization experiments on Podzols, Albeluvisols and Chernozems. Annual C inputs sufficient for maintaining constant SOM stocks and additional C gain were estimated. Simulation of SOC dynamics for plots with no fertilization and the lowest SOC stock revealed that above ground NPP input is sufficient for maintaining constant SOM stocks after conversion to a grassland for forage production and returning FYM in the same plot. The changes in the observed trends for different fields with the same treatments are related to the initial level of soil fertility and different crop-climatic year combinations. This simulation has demonstrated the role of crop rotations and fallowing in SOC dynamics and revealed possible C sequestration in a short-term as it is highly yield-dependent. Agricultural soils are sensitive to small changes of extreme year’s pattern with more expressed loss of the initial C stock under intensive management systems

Assessment of crop yields in modern agriculture on the basis of GIS-Technologies

Information-analytical system of ensuring agricultural technologies was developed on the base of several GIS and models of crop yield.The system included creation of maps of potential yield (function of the natural factors) and possible (function of the real level of the fieldfertility) yield of various crops. These dateswere received in the mass field experiments with fertilizers and in available modern bases ofagrochemical, landscape, climatic parameters. The uneven distribution of natural properties- for example, soil quality, topography, microclimate - on the territory of any size determined a different degree of their suitability for growing different groups of crops. The methodology for calculating the yield of various cropswas based on independent objective assessment of different impact factors bythe methods of linear and nonlinear multiple regression.Modeling results were presented in the form of yield maps with using several GIS.Impact yield factors are divided into two big groups – natural (climate, topography, soils, etc.) and agrochemical (applicationof fertilizers, plant protection agents, intensity of cultivation technologies, etc.)

Cascade frequency converters control features

The structures of systems with high-voltage cascade frequency converters containing multi-winding transformers and low-voltage low-power converters connected in series at each output phase of the load are considered. Low-voltage blocks contain three-phase diode or active rectifiers, DC capacitor filters, single-phase stand-alone voltage inverters and block disconnecting devices in partial modes (in case of failure when part of the blocks are disconnected). The possibilities of operation of cascade converters are determined, equations for correcting tasks to units in partial modes are given, tables of correction of tasks with estimates of achievable load characteristics are proposed. The results of experiments on the model of a powerful installation with a cascade frequency converter are presented, confirming the possibility of ensuring the symmetry of the load currents when disconnecting part of the blocks and the asymmetry of the circuit

Monitoring of Soil Fertility (Agroecological Monitoring)

Monitoring the ecological status of agricultural land is a fundamental precondition for controlling its sustainable functions for human society and for maintaining the ecosystem's capacity. We analyze fundamentals, developments, and trends and present results of agroecological monitoring in Russia. This system has been developed and operated by the Pryanishnikov Institute of Agrochemistry in Moscow. Agroecological monitoring in Russia was installed in the 1970s and is based on a regular 5-year agrochemical survey of agricultural lands all over the country, more than 300 field experiments in all bioclimatic zones of the country, and more than 1000 reference monitoring plots. In trials with different inputs of fertilizers, the focus is on analyzing soil fertility indicators and their impact on productivity. Some of these experiments are long-term experiments and part of international networks. Their results are of fundamental importance for monitoring, modeling, and controlling the status of soils in future despite climate change. In a regular survey, we found tendencies toward decreasing soil fertility in some regions, for example with decreased contents of humus and plant-available minerals, and topsoil acidification. Nutrient withdrawals must be compensated for by regular fertilization regimes, nutrient mining must be avoided. We detected some gaps in knowledge on the topic of balancing elements and modeling the agroecosystem's response to climate and land use changes. We conclude that there is a need to implement modern measurement and modeling systems in some key long-term trials. The Pryanishnikov Institute has taken responsibility for coordinating running programs in different regions and administrative units of the Russian Federation, and for elaborating methodical guidelines and highly advanced monitoring technologies. National and international cooperation, research programs and networks are key for agroecological monitoring systems of the twenty-first century in addressing challenges for a highly productive, stable, sustainable, and environmentally safe food production