Energy loss of channeled 290 MeV/u C 6 ions in a Si crystal

Abstract We have succeeded in observing the channeling of 290 MeV/u C 6 ions in a Si crystal. Under h1 1 0i axial, and (0 0 4), 2 2 0 and 1 1 1 planar channeling conditions, energy loss of the channeled ion in the Si crystal was observed. We also calculated the trajectory dependent stopping power for planar channeling ions, which employs mean and local electron densities evaluated adopting the Moli ere potential. Calculated energy loss spectra were found to reproduce the experimental results quite well. Ó 1998 Elsevier Science B.V

S=−1S=-1 Meson-Baryon Unitarized Coupled Channel Chiral Perturbation Theory and the S01−S_{01}- Λ\Lambda(1405) and −Λ- \Lambda(1670) Resonances

The $s-$wave meson-baryon scattering is analyzed for the strangeness $S=-1$ and isospin I=0 sector in a Bethe-Salpeter coupled channel formalism incorporating Chiral Symmetry. Four channels have been considered: $\pi \Sigma$, $\bar K N$, $\eta \Lambda$ and $K \Xi$. The required input to solve the Bethe-Salpeter equation is taken from lowest order Chiral Perturbation Theory in a relativistic formalism. There appear undetermined low energy constants, as a consequence of the renormalization of the amplitudes, which are obtained from fits to the $\pi\Sigma\to\pi\Sigma$ mass-spectrum, to the elastic $\bar K N \to \bar K N$ and $\bar K N\to \pi \Sigma$ $t$--matrices and to the $K^- p \to \eta \Lambda$ cross section data. The position and residues of the complex poles in the second Riemann Sheet of the scattering amplitude determine masses, widths and branching ratios of the $S_{01}-$ $\Lambda$(1405) and $-\Lambda$(1670) resonances, in reasonable agreement with experiment. A good overall description of data, from $\pi \Sigma$ threshold up to 1.75 GeV, is achieved despite the fact that three-body channels have not been explicitly included.Comment: 23 pages, Latex, 10 Figures. In this revised version a new subsection 3.6 on Heavy Baryon Expansion and new references have been adde

Renormalization of relativistic baryon chiral perturbation theory and power counting

We discuss a renormalization scheme for relativistic baryon chiral perturbation theory which provides a simple and consistent power counting for renormalized diagrams. The method involves finite subtractions of dimensionally regularized diagrams beyond the standard $\bar{\rm MS}$ scheme of chiral perturbation theory to remove contributions violating the power counting. This is achieved by a suitable renormalization of the parameters of the most general effective Lagrangian. In addition to simplicity our method has the benefit that it can be easily applied to multiloop diagrams. As an application we discuss the mass and the scalar form factor of the nucleon and compare the results with the expressions of the infrared regularization of Becher and Leutwyler.Comment: 20 pages, RevTex, 1 figure, published version is shortene

Computational modeling of beam-customization devices for heavy-charged-particle radiotherapy

A model for beam customization with collimators and a range-compensating filter based on the phase-space theory for beam transport is presented for dose distribution calculation in treatment planning of radiotherapy with protons and heavier ions. Independent handling of pencil beams in conventional pencil-beam algorithms causes unphysical collimator-height dependence in the middle of large fields, which is resolved by the framework comprised of generation, transport, collimation, regeneration, range-compensation, and edge-sharpening processes with a matrix of pencil beams. The model was verified to be consistent with measurement and analytic estimation at a submillimeter level in penumbra of individual collimators with a combinational-collimated carbon-ion beam. The model computation is fast, accurate, and readily applicable to pencil-beam algorithms in treatment planning with capability of combinational collimation to make best use of the beam-customization devices.Comment: 16 pages, 5 figure

Activation of Src Mediates PDGF-Induced Smad1 Phosphorylation and Contributes to the Progression of Glomerulosclerosis in Glomerulonephritis

Platelet-derived growth factor (PDGF) plays critical roles in mesangial cell (MC) proliferation in mesangial proliferative glomerulonephritis. We showed previously that Smad1 contributes to PDGF-dependent proliferation of MCs, but the mechanism by which Smad1 is activated by PDGF is not precisely known. Here we examined the role of c-Src tyrosine kinase in the proliferative change of MCs. Experimental mesangial proliferative glomerulonephritis (Thy1 GN) was induced by a single intravenous injection of anti-rat Thy-1.1 monoclonal antibody. In Thy1 GN, MC proliferation and type IV collagen (Col4) expression peaked on day 6. Immunohistochemical staining for the expression of phospho-Src (pSrc), phospho-Smad1 (pSmad1), Col4, and smooth muscle α-actin (SMA) revealed that the activation of c-Src and Smad1 signals in glomeruli peaked on day 6, consistent with the peak of mesangial proliferation. When treated with PP2, a Src inhibitor, both mesangial proliferation and sclerosis were significantly reduced. PP2 administration also significantly reduced pSmad1, Col4, and SMA expression. PDGF induced Col4 synthesis in association with increased expression of pSrc and pSmad1 in cultured MCs. In addition, PP2 reduced Col4 synthesis along with decreased pSrc and pSmad1 protein expression in vitro. Moreover, the addition of siRNA against c-Src significantly reduced the phosphorylation of Smad1 and the overproduction of Col4. These results provide new evidence that the activation of Src/Smad1 signaling pathway plays a key role in the development of glomerulosclerosis in experimental glomerulonephritis