57 research outputs found
Normal families of functions and groups of pseudoconformal diffeomorphisms of quaternion and octonion variables
This paper is devoted to the specific class of pseudoconformal mappings of
quaternion and octonion variables. Normal families of functions are defined and
investigated. Four criteria of a family being normal are proven. Then groups of
pseudoconformal diffeomorphisms of quaternion and octonion manifolds are
investigated. It is proven, that they are finite dimensional Lie groups for
compact manifolds. Their examples are given. Many charactersitic features are
found in comparison with commutative geometry over or .Comment: 55 pages, 53 reference
Pneumocystis murina colonization in immunocompetent surfactant protein A deficient mice following environmental exposure
<p>Abstract</p> <p>Background</p> <p><it>Pneumocystis spp</it>. are opportunistic pathogens that cause pneumonia in immunocompromised humans and animals. <it>Pneumocystis </it>colonization has also been detected in immunocompetent hosts and may exacerbate other pulmonary diseases. Surfactant protein A (SP-A) is an innate host defense molecule and plays a role in the host response to <it>Pneumocystis</it>.</p> <p>Methods</p> <p>To analyze the role of SP-A in protecting the immunocompetent host from <it>Pneumocystis </it>colonization, the susceptibility of immunocompetent mice deficient in SP-A (KO) and wild-type (WT) mice to <it>P. murina </it>colonization was analyzed by reverse-transcriptase quantitative PCR (qPCR) and serum antibodies were measured by enzyme-linked immunosorbent assay (ELISA).</p> <p>Results</p> <p>Detection of <it>P. murina </it>specific serum antibodies in immunocompetent WT and KO mice indicated that the both strains of mice had been exposed to <it>P. murina </it>within the animal facility. However, P. <it>murina </it>mRNA was only detected by qPCR in the lungs of the KO mice. The incidence and level of the mRNA expression peaked at 8–10 weeks and declined to undetectable levels by 16–18 weeks. When the mice were immunosuppressed, <it>P. murina </it>cyst forms were also only detected in KO mice. <it>P. murina </it>mRNA was detected in <it>SCID </it>mice that had been exposed to KO mice, demonstrating that the immunocompetent KO mice are capable of transmitting the infection to immunodeficient mice. The pulmonary cellular response appeared to be responsible for the clearance of the colonization. More CD4+ and CD8+ T-cells were recovered from the lungs of immunocompetent KO mice than from WT mice, and the colonization in KO mice depleted CD4+ cells was not cleared.</p> <p>Conclusion</p> <p>These data support an important role for SP-A in protecting the immunocompetent host from <it>P. murina </it>colonization, and provide a model to study <it>Pneumocystis </it>colonization acquired via environmental exposure in humans. The results also illustrate the difficulties in keeping mice from exposure to <it>P. murina </it>even when housed under barrier conditions.</p
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Railgun power supply system utilizing traction motors and vacuum interrupters
A railgun power supply has been designed that utilizes traction motors, vacuum interrupters and pulse transformers. An assembly of 28 traction motors, which store approximately 75 MJ, energize the primary windings of three pulse transformers at a peak current of 50 kA. At peak current an array of vacuum interrupters disconnects the transformer primary windings and forces the current to flow in the secondary windings. The secondary windings are connected directly to the railgun and require no opening switches. By staging the vacuum interrupter openings, a 1 MA to 1.3 MA ramped current waveform can be delivered to the railgun
A Mild Hydroaminoalkylation of Conjugated Dienes Using a Unified Cobalt and Photoredox Catalytic System
Metallo-photoredox
catalysis has redefined the available bond disconnections
in the synthetic arsenal. By harnessing the one-electron chemistry
of photoredox catalysis in tandem with low-valent cobalt catalysts,
new methods by which functionalities may be stitched together become
available. Herein we describe the coupling of photoredox-generated
α-amino radical species with conjugated dienes using a unified
cobalt and iridium catalytic system in order to access a variety of
useful homoallylic amines from simple commercially available starting
materials. We present a series of mechanistic experiments that support
the intervention of Co–hydride intermediates that undergo diene
insertion to generate Co−π-allyl species
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Superconducting solenoid designed for 400 kJ at 25 kA under conditions of fast discharge and field reversal
A 1.26-mH superconducting solenoid made of NbTi and Cu-CuNi mixed matrix superconductor was designed and fabricated by Westinghouse Electric Corporation for the Los Alamos National Laboratory as part of the pulsed energy storage coil program. The coil was designed to store 400 kJ at a current of 25 kA and has been operated to currents of 20 kA. Development of high current cables and low-loss superconductors are both necessary undertakings for future fusion devices. The first tests of the coil involved a very slow charge of the coil followed by a rapid discharge in 1.07 ms with a capacitor bank and a normal-conductor load coil in a resonant L-C-L circuit. The second test consisted of a slow charge followed by a discharge and recharge on a time scale of a few seconds. This latter cycle resembles that expected in a tokamak induction coil. Loss measurements were made by an electrical method during the second series of tests
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