Development And Validation Of Stability Indicating RP-HPLC Method For Determination Of Ceritinib

A new, simple, specific, accurate and precise RP-HPLC method was developed for determination of Ceritinib. In the present study, stress testing of Ceritinib was carried out according to ICH guidelines Q1A (R2). Ceritinib was subjected to stress conditions of hydrolysis, oxidation, photolysis and neutral decomposition. Extensive degradation was found to occur in acidic, condition. Mild degradation was observed in basic and at thermal conditions. Successful separation of drug from degradation products formed under stress conditions was achieved on a Hypersil BDS C18 column (250 mm × 4.6 mm, 5.0 μ particle size) using acetonitrile: acetate buffer (pH 3.7 ± 0.05) (50:50 v/v), at a flow rate of 1.0 mL/min and column was maintained at 40˚C. Quantification and linearity was achieved at 272 nm over the concentration range of 5 - 100 μg/mL for Ceritinib. The method was validated for specificity, linearity, accuracy, precision, LOD, LOQ and robustness

A Parallel Fuzzy C-Mean algorithm for Image Segmentation

This paper proposes a parallel Fuzzy C-Mean (FCM) algorithm for image segmentation. The sequential FCM algorithm is computationally intensive and has significant memory requirements. For many applications such as medical image segmentation and geographical image analysis that deal with large size images, sequential FCM is very slow. In our parallel FCM algorithm, dividing the computations among the processors and minimizing the need for accessing secondary storage, enhance the performance and efficiency of image segmentation task as compared to the sequential algorithm. such as medical image segmentation and geographical image analysis that deal with large size images, sequenrial FCM is very slow. In our parallel FCM algorithm, dividing the computations among the processors and minimizing the need for accessing secondary storage, enhance the performance and efficiency of image segmentation task as compared to the sequential algorith

High Pressure Study of IrN in Zinc-Blende Structure

The structural phase transition, volume collapse and second order elastic constants of 5d-transition metal mononitride (IrN) have been investigated by using interaction potential model (IPM) which consists of Coulomb interaction, three-body interaction and short range overlap repulsive interactions. The present theoretical approach has predicted pressure-volume relationship curves which shows that IrN exhibits a zinc-blend (ZB) type structure at an ambient pressure and undergoes a structural phase transition from B3 to B1 phase at pressure 72 GPa. The equation of state shows volume collapse of 9.09 %. The phase transition pressure and associated volume collapses obtained from this model show a reasonable agreement with other theoretical results. The second order elastic constants are also investigated for ZB phase. Keywords: High Pressure, Phase Transition, Transition Metal Compound

Detecting Malicious Applications from the cloud by using user feedback method

As in recent period of computers and internets, mobiles devices, Smartphone’s plays a vital role in human day to day activities. Also now a days Smartphone’s & tablets are becoming very popular especially android based Smartphone’s are gaining much more popularity as compared to Apple’s iOS. These Smartphone’s having lot of applications and features based on only internet but these new emerging features of these devices give opportunity to new malwares & threats. Android is comparatively new OS hence its makes very hard to detect and prevent these viruses and malwares attacks by using some basic traditional mechanisms. So security of these Smartphone’s is now becoming very popular issue of researchers. The lack of standard security mechanism in Android applications is very useful to hackers. So to overcome these various pitfalls we use cloud services as a security weapon for providing decent security system for Android applications

Design and Analysis of Two Spindle Amber Charkha- A Review

The Charkha is a small device which can be used to spin fiber, such as cotton, into yarn. Fabric from this yarn can be used to make all sorts of clothing. Increasing demands of the cotton fabrics, now a days, has made it necessary to increase the production of cotton fabrics. To increase the production it is necessary to study the factors affecting the performance of the women workers working on Amber charkha. Most of the Amber charkha in rural areas are hand operated (i.e. they run with the help of human energy input). This paper highlights some of the factors which are responsible for their performance. The various factors that are affecting the productivity are technical factor, their weight and cost of the two spindle amber charkha. Each of these factors plays an important role in the overall performance of the workers. The detailed study is carried out to design and analysis of two spindle of Amber charkha. The basic necessity of this study is to minimize its weight and price which would help the workers for achieving better productivity with work satisfaction