Calcium, Magnesium, Iron, Zinc and Copper, Compositions of Human Milk from Populations with Cereal and ‘Enset’ Based Diets

Backround: As breast milk is normally the only source of food in the early stages of life, the dietary levels of the essential elements in the milk of lactating mothers are significantly important. Ethiopia is a country of many nations and nationalities with distinct dietary habits. This variation in food habit may result in the variation of the nutritional quality of milk of lactating mothers who live in different part of the country, which in turn may affect the intake of nutrients by breast-fed infants. Therefore, a cross-sectional study of the levels of Ca, Mg, Fe, Zn and Cu in milk of mothers from societies with cereal and ‘enset’ based dietary habits was carried out to assess the influence of maternal diet on the levels of the elements in human milk.Methods: Milk samples were collected from 27 voluntary mothers in Jimma and in 18 rural areas of Welkite. Breast milk samples were collected within four days postpartum and the concentrations of the elements were determined by using FAAS.Results: Average concentrations (mg/L) of the elements determined in the milk of mothers from Jimma and rural Welkite respectively were: Ca (758 ± 107, 579 ± 168); Mg (22.6 ± 7.87, 30.5 ± 13.4); Fe (0.50 ± 0.08, 0.41 ± 0.17); Zn (2.3 ± 1.2, 2.49 ± 0.88) and Cu (0.28 ± 0.14, 0.16 ± 0.08).Conclusions: Milk samples from Jimma were found to have significantly higher levels of Ca and Cu than those of rural Welkite (P < 0.05). Breast milk Ca and Cu levels were thus found to be influenced by dietary intake.Keywords: Human milk, Ethiopia, Welkite, Jimma, Essential elements, ‘Teff’, ‘Enset’

Anti-inflammatory sesquiterpenes from Curcuma zedoaria

This is a preprint of an article whose final and definitive form has been published in the NATURAL PRODUCT RESEARCH © 2006 copyright Taylor & Francis; NATURAL PRODUCT RESEARCH is available online at: http://www.informaworld.com/openurl?genre=article&issn=1478-6419&volume=20&issue=7&spage=680ArticleNATURAL PRODUCT RESEARCH. 20(7): 680-685 (2006)journal articl

Higgs Production via Gluon Fusion in a Six Dimensional Universal Extra Dimension Model on S^2/Z_2

We investigate Higgs boson production process via gluon fusion at LHC in our six dimensional universal extra dimension model compactified on a spherical orbifold S^2/Z_2. We find a striking result that Higgs production cross section in our model is predicted to be 30(10)% enhancement comparing to the predictions of the Standard Model (the minimal universal extra dimension model) for the compactification scale of order 1 TeV.Comment: 9 pages, 2 eps files, Final version to appear in EPJ

(S)fermion Masses in Fat Brane Scenario

We discuss the fermion mass hierarchy and the flavor mixings in the fat brane scenario of a five dimensional SUSY theory. Assuming that the matter fields lives in the bulk, their zero mode wave functions are Gaussians, and Higgs fields are localized on the brane, we find simple various types of the matter configurations generating the mass matrices consistent with experimental data. Sfermion mass spectrum is also discussed using the matter configurations found above. Which type of squark mass spectra (the degeneracy, the decoupling and the alignment) is realized depends on the relative locations of SUSY breaking brane and the brane where Higgs fields are localized.Comment: 18 pages, LaTe

Analysis of adam12-mediated ephrin-a1 cleavage and its biological functions

Accumulating evidence indicates that an elevated ephrin-A1 expression is positively correlated with a worse prognosis in some cancers such as colon and liver cancer. The detailed mechanism of an elevated ephrin-A1 expression in a worse prognosis still remains to be fully elucidated. We previously reported that ADAM12-cleaved ephrin-A1 enhanced lung vascular permeability and thereby induced lung metastasis. However, it is still unclear whether or not cleaved forms of ephrin-A1 are derived from primary tumors and have biological activities. We identified the ADAM12-mediated cleavage site of ephrin-A1 by a Matrix-assisted laser desorption ionization mass spectrometry and checked levels of ephrin-A1 in the serum and the urine derived from the primary tumors by using a mouse model. We found elevated levels of tumor-derived ephrin-A1 in the serum and the urine in the tumor-bearing mice. Moreover, inhibition of ADAM-mediated cleavage of ephrin-A1 or antagonization of the EphA receptors resulted in a significant reduction of lung metastasis. The results suggest that tumor-derived ephrin-A1 is not only a potential biomarker to predict lung metastasis from the primary tumor highly expressing ephrin-A1 but also a therapeutic target of lung metastasis

Realistic construction of split fermion models

The Standard Model flavor structure can be explained in theories where the fermions are localized on different points in a compact extra dimension. We show that models with two bulk scalars compactified on an orbifold can produce such separations in a natural way. We study the shapes and overlaps of the fermion wave functions. We show that, generically, realistic models of Gaussian overlaps are unnatural since they require very large Yukawa couplings between the fermions and the bulk scalars. We give an example of a five dimensional two scalar model that accounts naturally for the observed quark masses, mixing angles and CP violation.Comment: 15 pages, 5 figures, typos corrected, discussion on the implications of SM rare decay processes added, to appear in PR

Non-Abelian Walls in Supersymmetric Gauge Theories

The Bogomol'nyi-Prasad-Sommerfield (BPS) multi-wall solutions are constructed in supersymmetric U(N_C) gauge theories in five dimensions with N_F(>N_C) hypermultiplets in the fundamental representation. Exact solutions are obtained with full generic moduli for infinite gauge coupling and with partial moduli for finite gauge coupling. The generic wall solutions require nontrivial configurations for either gauge fields or off-diagonal components of adjoint scalars depending on the gauge. Effective theories of moduli fields are constructed as world-volume gauge theories. Nambu-Goldstone and quasi-Nambu-Goldstone scalars are distinguished and worked out. Total moduli space of the BPS non-Abelian walls including all topological sectors is found to be the complex Grassmann manifold SU(N_F) / [SU(N_C) x SU(N_F-N_C) x U(1)] endowed with a deformed metric.Comment: 62 pages, 17 figures, the final version in PR

Models of Dynamical Supersymmetry Breaking with Gauged U(1)RU(1)_R Symmetry

We present simple models of dynamical supersymmetry breaking with gauged U(1)_R symmetry. The minimal supersymmetric standard model and supersymmetric SU(5) GUT are considered as the visible sector. The anomaly cancellation conditions for U(1)_R are investigated in detail and simple solutions of the R-charge assignments are found. We show that this scenario of dynamical supersymmetry breaking is phenomenologically viable with the gravitino mass of order 1 TeV or 10 TeV.Comment: 15 pages, uses REVTEX macro, No figure

Ursodeoxycholic acid as a novel disease-modifying treatment for Parkinson’s disease: protocol for a two-centre, randomised, double-blind, placebo-controlled trial, The 'UP' study

Introduction There are no disease-modifying treatments for Parkinson’s disease (PD). We undertook the first drug screen in PD patient tissue and idntified ursodeoxycholic acid (UDCA) as a promising mitochondrial rescue agent. The aims of this trial are to determine safety and tolerability of UDCA in PD at 30 mg/kg, confirm the target engagement of UDCA, apply a novel motion sensor-based approach to quantify disease progression objectively, and estimate the mean effect size and its variance on the change in motor severity. Methods and analysis This is a phase II, two-centre, double-blind, randomised, placebo-controlled trial of UDCA at a dose of 30 mg/kg in 30 participants with early PD. Treatment duration is 48 weeks, followed by an 8-week washout phase. Randomisation is 2:1, drug to placebo. Assessments are performed at baseline, week 12, 24, 36, 48 and 56. The primary outcome is safety and tolerability. Secondary outcomes will compare the change between baseline and week 48 using the following three approaches: the Movement Disorders Society Unified Parkinson’s Disease Rating Scale Part 3 in the practically defined ‘OFF’ medication state; confirmation of target engagement, applying 31Phosphorus MR Spectroscopy to assess the levels of ATP and relevant metabolites in the brain; and objective quantification of motor impairment, using a validated, motion sensor-based approach. The primary outcome will be reported using descriptive statistics and comparisons between treatment groups. For each secondary outcome, the change from baseline will be summarised within treatment groups using summary statistics and appropriate statistical tests assessing for significant differences. All outcomes will use an intention-to-treat analysis population. Ethics and dissemination This trial has been approved by the East of England – Cambridgeshire and Hertfordshire Research Ethics committee. Results will be disseminated in peer-reviewed journals, presentations at scientific meetings and to patients in a lay-summary format. Trial registration number NCT03840005

Systematic review and meta-analysis: prevalence of alcohol use among young people in eastern Africa.

OBJECTIVE: Systematic review and meta-analysis of published studies of alcohol use among young people (age 15-24 years) in eastern Africa to estimate prevalence of alcohol use and determine the extent of use of standardised screening questionnaires in alcohol studies. METHODS: Five databases (MEDLINE, EMBASE, Global Health, Africa-wide, and PsycINFO) were searched for publications until 30th June 2013. Results were summarised using the guidelines on preferred reporting items for systematic reviews and meta-analyses (PRISMA) and on quality assessment using the modified quality assessment tool for systematic reviews of observational studies (QATSO). Heterogeneity was assessed using the I(2) statistic (DerSimonian-Laird). RESULTS: We identified 2785 potentially relevant studies, of which 56 were eligible for inclusion. Only two studies (4%) used the standardised Alcohol Use Disorder Identification Test (AUDIT) questionnaire, and six studies (13%) used the Cut down, Annoyed, Guilt, Eye opener (CAGE) questionnaire. The reported median prevalence of alcohol use was ever-use 52% [interquartile range (IQR): 20-58%], use in the last month 28% (IQR: 17-37%), use in the last year 26% (IQR: 22-32%), and problem drinking as defined by CAGE or AUDIT 15% (IQR: 3-36%). We observed high heterogeneity between studies, with the highest prevalence of ever use of alcohol among university students (82%; 95%CI: 79-85%) and female sex workers (66%; 95%CI: 58-74%). Current use was most prevalent among male sex workers (69%; 95%CI: 63-75%). CONCLUSIONS: Reported alcohol use and problem drinking were common among diverse groups of young people in eastern Africa, indicating the urgent need for alcohol-focused interventions in this population. Few studies have used standardised alcohol screening questionnaires. Epidemiological research to investigate alcohol-focused interventions in young people should aim to apply such questionnaires that should be validated for use in this population