1,616 research outputs found
Changes in body weight and body fat distribution as risk factors for clinical diabetes in US men
Ultimate Failure Behaviour of Second-generation Sheeting Subjected to Combined Bending Moment and Concentrated Load
Second-generation sheeting is widely used for cladding and roof construction. At interior supports, it is subjected to combined bending moment and concentrated load. Unfortunately, design rules for this loading are complicated and do not provide insight in the sheeting\u27s failure behaviour. This means there is a need for a new, insight providing design rule. For first-generation sheeting, a similar problem did exist. The Technische Universiteit Eindhoven (TUE) carried out three research projects [Bakk92a,Vaes95a,Hofm00a] that provided insight in the first-generation sheeting behaviour and resulted in a new, insight providing design rule. The TUE now uses the strategy of these three research projects for a new project on second-generation sheeting [Kasp01a], with the final aim of a new design rule for second-generation sheeting. In this new project, experiments on commonly used (in the Netherlands) second-generation sheeting were carried out. Second-generation sheeting behaviour was compared with first-generation sheeting behaviour. For sheeting with only stiffeners in flange, load falls occur before ultimate load. Stiffeners in the web only result in load falls after the ultimate load. For an experiment with only stiffeners in the web, a finite element simulation was made. The simulation predicts the sheeting behaviour fairly well and indicates how a stiffener affects the sheeting behaviour
The cross-sectional resistance of square and rectangular hollow steel sections loaded by bending moment and shear force
This paper presents an evaluation of the design rules for the bending moment–shear force (M−V) interaction of cold- and hot-formed square, and rectangular hollow steel sections (SHS & RHS). More specifically, the design rules, as provided by EN1993-1-1 regarding RHS and SHS of section class 1 and 2 are covered for the steel grades S235 up to and including S460. A 4-point bending test was simulated by means of a finite element model, which was validated on the basis of experimental tests from existing literature. A parametric study was performed and numerical M−V interaction results were compared to the provisions in EN1993-1-1. This comparison indicates that the current design rules in EN1993-1-1 regarding M−V interaction are conservative and overestimate the reduction of the bending resistance due to the presence of shear. Alternative design rules for the shear area and M−V interaction of RHS and SHS are proposed and evaluated by means of a statistical assessment procedure based on existing literature and EN1990-1-1. Both newly developed design rules are shown to ensure an adequate reliability level when a partial safety factor equal to 1 is used.</p
Discovery of a small arterivirus gene that overlaps the GP5 coding sequence and is important for virus production
The arterivirus family (order Nidovirales) of single-stranded, positive-sense RNA viruses includes porcine respiratory and reproductive syndrome virus and equine arteritis virus (EAV). Their replicative enzymes are translated from their genomic RNA, while their seven structural proteins are encoded by a set of small, partially overlapping genes in the genomic 3′-proximal region. The latter are expressed via synthesis of a set of subgenomic mRNAs that, in general, are functionally monocistronic (except for a bicistronic mRNA encoding the E and GP2 proteins). ORF5, which encodes the major glycoprotein GP5, has been used extensively for phylogenetic analyses. However, an in-depth computational analysis now reveals the arterivirus-wide conservation of an additional AUG-initiated ORF, here termed ORF5a, that overlaps the 5′ end of ORF5. The pattern of substitutions across sequence alignments indicated that ORF5a is subject to functional constraints at the amino acid level, while an analysis of substitutions at synonymous sites in ORF5 revealed a greatly reduced frequency of substitution in the portion of ORF5 that is overlapped by ORF5a. The 43–64 aa ORF5a protein and GP5 are probably expressed from the same subgenomic mRNA, via a translation initiation mechanism involving leaky ribosomal scanning. Inactivation of ORF5a expression by reverse genetics yielded a severely crippled EAV mutant, which displayed lower titres and a tiny plaque phenotype. These defects, which could be partially complemented in ORF5a-expressing cells, indicate that the novel protein, which may be the eighth structural protein of arteriviruses, is expressed and important for arterivirus infection
Partner choice and cooperation in social dilemmas can increase resource inequality
Cooperation is more likely when individuals can choose their interaction partner. However, partner choice may be detrimental in unequal societies, in which individuals differ in available resources and productivity, and thus in their attractiveness as interaction partners. Here we experimentally examine this conjecture in a repeated public goods game. Individuals (n = 336), participating in groups of eight participants, are assigned a high or low endowment and a high or low productivity factor (the value that their cooperation generates), creating four unique participant types. On each round, individuals are either assigned a partner (assigned partner condition) or paired based on their self-indicated preference for a partner type (partner choice condition). Results show that under partner choice, individuals who were assigned a high endowment and high productivity almost exclusively interact with each other, forcing other individuals into less valuable pairs. Consequently, pre-existing resource differences between individuals increase. These findings show how partner choice in social dilemmas can amplify resource inequality
Discovery of a small arterivirus gene that overlaps the GP5 coding sequence and is important for virus production
The arterivirus family (order Nidovirales) of single-stranded, positive-sense RNA viruses includes porcine respiratory and reproductive syndrome virus and equine arteritis virus (EAV). Their replicative enzymes are translated from their genomic RNA, while their seven structural proteins are encoded by a set of small, partially overlapping genes in the genomic 3′-proximal region. The latter are expressed via synthesis of a set of subgenomic mRNAs that, in general, are functionally monocistronic (except for a bicistronic mRNA encoding the E and GP2 proteins). ORF5, which encodes the major glycoprotein GP5, has been used extensively for phylogenetic analyses. However, an in-depth computational analysis now reveals the arterivirus-wide conservation of an additional AUG-initiated ORF, here termed ORF5a, that overlaps the 5′ end of ORF5. The pattern of substitutions across sequence alignments indicated that ORF5a is subject to functional constraints at the amino acid level, while an analysis of substitutions at synonymous sites in ORF5 revealed a greatly reduced frequency of substitution in the portion of ORF5 that is overlapped by ORF5a. The 43–64 aa ORF5a protein and GP5 are probably expressed from the same subgenomic mRNA, via a translation initiation mechanism involving leaky ribosomal scanning. Inactivation of ORF5a expression by reverse genetics yielded a severely crippled EAV mutant, which displayed lower titres and a tiny plaque phenotype. These defects, which could be partially complemented in ORF5a-expressing cells, indicate that the novel protein, which may be the eighth structural protein of arteriviruses, is expressed and important for arterivirus infection
Experimental Research on the Behaviour of Combined Web Crippling and Bending of Steel Deck Sections
At an interior support, sections of cold-formed steel are subjected to a concentrated load and a bending moment Existing design rules describing the section failure at an interior support are subject to improvement and are not based on the section\u27s physical failure behaviour. In the last decade, several analytical models have been developed that predict the section ultimate concentrated load and directly include the influence of the bending moment, so that an empirical interaction method is not needed. However, the authors believe that these models are correct only for a concentrated load and a small bending moment In practice large bending moments occur. Therefore, the aim of the current research project is to develop an analytical model for trapezoidal hat sections subjected to a concentrated load and a bending moment as occurring in practice. The development of this model will be based on both experimental and numerical research will be carried out. In this article, a part of the experimental research will be presented
Experimental Research on the Behaviour of Combined Web Crippling and Bending of Steel Deck Sections
At an interior support, sections of cold-formed steel are subjected to a concentrated load and a bending moment Existing design rules describing the section failure at an interior support are subject to improvement and are not based on the section\u27s physical failure behaviour. In the last decade, several analytical models have been developed that predict the section ultimate concentrated load and directly include the influence of the bending moment, so that an empirical interaction method is not needed. However, the authors believe that these models are correct only for a concentrated load and a small bending moment In practice large bending moments occur. Therefore, the aim of the current research project is to develop an analytical model for trapezoidal hat sections subjected to a concentrated load and a bending moment as occurring in practice. The development of this model will be based on both experimental and numerical research will be carried out. In this article, a part of the experimental research will be presented
- …