Modeling and Analysis of Resource Sharing Approach in Common Platform Strategy Using Petri Net Theory

The most competitive advantages in business and manufacturing is resource-sharing.We must share common resources to produce a group of product family with using common platform strategy. This strategy helps us to increase profit and value in business. It is necessary to apply this strategy to model and analyze resource achievability in different situations. In this paper we try to develop a practical model for analyzing common resource behavioral in platform area with using Petri net theory. Petri Nets have been successfully used for modeling and control the dynamics of flexible manufacturing systems.This paper presents some important concepts about common platform and petri net theory and then presents numerical examples to show how to use Petri net for modeling and analysis in common platform. This model is very useful for common platform strategy and can be used to determine reliability of common platform systems in an effective way

Versatility and modifications of the cross-finger flap in reconstruction of digital soft tissue defect

Background: Hand injuries can cause major functional and cosmetic concerns. The cross-finger flap (CFF) is an effective treatment for complex finger defects. While CFF has typically been employed to treat volar aspect abnormalities, new versions now address a larger variety of digital soft tissue defects. The aim of the study was to evaluate the clinical outcome of various modified techniques of cross-finger flap which are used to reconstruct different soft tissue defect of fingers. Methods: This was a prospective observational study carried out in the department of Burn and Plastic Surgery at Dhaka Medical College Hospital, Dhaka from September 2018 to February 2020. Forty (40) patients who presented with different soft tissue defect of fingers included in this study according to inclusion and exclusion criteria. Results: The study involved predominantly male participants (80%), with a mean age of 31.70±14.28 years. The most common soft tissue defect site was the volar area (47.5%), and various modified cross-finger flap techniques were employed. The majority of patients achieved excellent functional outcomes, with 82.5% classified as good, 12.5% as satisfactory, and 5.0% as poor. Conclusions: The modifications of the cross-finger flap are versatile and useful for different sites of digital injuries with good functional outcome

Susceptibility of optimal train schedules to stochastic disturbances of process times

This work focuses on the stochastic evaluation of train schedules computed by a microscopic scheduler of railway operations based on deterministic information. The research question is to assess the degree of sensitivity of various rescheduling algorithms to variations in process times (running and dwell times). In fact, the objective of railway traffic management is to reduce delay propagation and to increase disturbance robustness of train schedules at a network scale. We present a quantitative study of traffic disturbances and their effects on the schedules computed by simple and advanced rescheduling algorithms. Computational results are based on a complex and densely occupied Dutch railway area; train delays are computed based on accepted statistical distributions, and dwell and running times of trains are subject to additional stochastic variations. From the results obtained on a real case study, an advanced branch and bound algorithm, on average, outperforms a First In First Out scheduling rule both in deterministic and stochastic traffic scenarios. However, the characteristic of the stochastic processes and the way a stochastic instance is handled turn out to have a serious impact on the scheduler performance

Genetic diversity of pran (Allium cepa var. prolliferum) in Kashmir

Ten pran genotypes were evaluated using RAPD markers to determine the genetic relationships among genotypes showing morphological variations. Fourty three decamer primers were used in this study. Genetic diversity in the genotypes studied was analyzed using several variability parameters. Genotypes were grouped into two main clusters based on jaccard similarity coefficient. A dendrogram based on UPGMA analysis grouped the ten genotypes into two main clusters. Genotypes representing cluster-I are superior over genotypes in cluster-II with respect to yield attributes. Some genotypes did not show any similarity with either cluster, depicting their diverse nature. The grouping that was obtained with the RAPD analysis was at par with the morphological grouping based on yield attributes. The results of Principal Co-ordinate (PCO) analysis were comparable to the cluster analysis. Finally, the investigation of the genetic variation of pran with RAPD indicated that this marker is a suitable tool for assessing polymorphism and estimating the genetic similarity. &nbsp

The In Vivo Role of the RP-Mdm2-p53 Pathway in Signaling Oncogenic Stress Induced by pRb Inactivation and Ras Overexpression

The Mdm2-p53 tumor suppression pathway plays a vital role in regulating cellular homeostasis by integrating a variety of stressors and eliciting effects on cell growth and proliferation. Recent studies have demonstrated an in vivo signaling pathway mediated by ribosomal protein (RP)-Mdm2 interaction that responds to ribosome biogenesis stress and evokes a protective p53 reaction. It has been shown that mice harboring a Cys-to-Phe mutation in the zinc finger of Mdm2 that specifically disrupts RP L11-Mdm2 binding are prone to accelerated lymphomagenesis in an oncogenic c-Myc driven mouse model of Burkitt's lymphoma. Because most oncogenes when upregulated simultaneously promote both cellular growth and proliferation, it therefore stands to reason that the RP-Mdm2-p53 pathway might also be essential in response to oncogenes other than c-Myc. Using genetically engineered mice, we now show that disruption of the RP-Mdm2-p53 pathway by an Mdm2C305F mutation does not accelerate prostatic tumorigenesis induced by inactivation of the pRb family proteins (pRb/p107/p130). In contrast, loss of p19Arf greatly accelerates the progression of prostate cancer induced by inhibition of pRb family proteins. Moreover, using ectopically expressed oncogenic H-Ras we demonstrate that p53 response remains intact in the Mdm2C305F mutant MEF cells. Thus, unlike the p19Arf-Mdm2-p53 pathway, which is considered a general oncogenic response pathway, the RP-Mdm2-p53 pathway appears to specifically suppress tumorigenesis induced by oncogenic c-Myc

Scuffing of cast iron and steel under dry sliding conditions

SIGLEAvailable from British Library Document Supply Centre- DSC:D37466/81 / BLDSC - British Library Document Supply CentreGBUnited Kingdo

The effect of Isoproterenol on protein electrophoretic pattern of rabbit salivary glands

Abstract: Isoproterenol is a potent ?-adrenergic agonist which its effect on rabbit salivary glands has been studied in this research. Two groups of male albino rabbits (Five in each group with the mean weight of 1000±300 gr) were injected with 20 mg/kg of isoproterenol intrapritoneally each day for fifteen days and one similar group (n=5) was chosen as control group. In one of the test groups in addition to normal diet (Dry food) animals were fed by liquid diet. Increase in the weight of parotid salivary gland was five folds in test groups as compared to control group (P<0.01). Also, twelve folds increase in total protein content of the gland was observed in test groups as compared to control group (P<0.01). The increase in submandibular gland weight was significant but not as much as that in parotid gland (P<0.01). The total protein of submandibular glands of those experimental animals which were fed with solid diet was 2.5 folds as compared to control group (P<0.01). The total protein of the other test group fed with liquid diet showed a non-significant increase in comparison to control group. The increase in submandibular gland weight was significant in this group compared to control group (P<0.01). Regarding sublingual gland, there was just significant increase in weight of gland in the solid diet group (P<0.01). However, the increase in total protein content of sublingual glands of experimental groups was not significant compared to control group. Sodium Dodecyl Sulfate Polyacrylamide gel Electrophoresis of parotid gland revealed protein bands with molecular weights of about 14, 44, 58, 96 and 98 KD in experimental groups compated to control group. Electrophoretic pattern of submandibular gland of test groups showed protein bands with 20.KD which probably is a kind of Proline-rich proteins. Since isoproterenol was not effective on sublingual gland, significant difference in its electrophoretic pattern was not observed. Keywords: Isoproterenol, Salivary gland, Proline-rich protein, Rabbi