Consumer attitudes to vaccination of food-producing animals

Summary The 2001 outbreak of foot and mouth disease in the United Kingdom was unprecedented, with the need to develop a vaccination policy at the height of the epidemic. The extent of consumer concerns about eating products derived from vaccinated animals was unknown as survey results were equivocal. A recent survey on avian influenza reveals that the European public are well informed about the disease and its control, but over 50% of respondents would be reluctant to consume meat from vaccinated birds. There is little specific information available on consumer views about routine vaccination for other diseases. Their concerns appear to increase in an emergency situation when there is heightened awareness through the media. With the development of newer types of vaccines consumers will need more assurance about the safety and use of these products. This article examines these issues and makes practical recommendations for ensuring public confidence when emergency vaccination for disease control is proposed

A Comparative Analysis Of Army Body Composition Standards For Women

International Journal of Exercise Science 13(7): 1275-1282, 2020. The aim of this study was to compare body fat percentage (BF%) of women measured using the U.S. Army standard body composition assessment (ABC) and two common laboratory measures of body composition to evaluate the efficacy of ABC within this population. The BF% of 27 women (21.5 ± 1.8 years) was assessed using the 7-site skinfold, air plethysmography, and ABC measurements. The initial physical fitness test (IPFT) was used to determine if participants met the criteria required for admittance into basic combat training. A repeated measures ANOVA identified differences in BF% between the three assessment methods, (F (2, 52) = 22.83, p \u3c .001, η2p = .47). Pairwise comparisons revealed that mean BF% obtained using the ABC (29.3 ± 7.7 %) was significantly higher (p = .042) than BF% measured using air plethysmography (26.9 ± 8.4 %). ABC and air plethysmography measured BF% was significantly higher (both p \u3c .001) than BF% obtained from skinfold assessment (22.2 ± 5.9 %). Of the 27 total participants, 4 (14.8%) passed IPFT but failed to meet the Army body composition standards using the ABC method. The primary findings of this study suggest that the overestimation of BF% by the ABC method could lead to an unnecessary delay in enlistment for women approaching the upper threshold of the Army’s acceptable body composition standards. Alternative methods of assessing body composition in this population should be explored. However, skinfold assessment does not appear to be a suitable alternative to the ABC

Caffeine Alters RPE-Based Intensity Production

International Journal of Exercise Science 12(6): 412-424, 2019. This study examined effects of caffeine (CAF) on power output (PO) selection and associated physiological responses during cycling at moderate and high intensities prescribed by RPE (0-10 scale). Participants (n = 9) (VO2peak: 55.4 ± 6.32 mL · kg-1 · min-1) cycled for 20 min at RPE4 and 20 min at RPE7 separated by 10 min recovery following caffeine (CAF) (6 mg · kg-1) and placebo (PLA) ingestion. PO, HR, serum lactate [La], VO2, VE, and RER were recorded every 5 min. Session RPE (S-RPE) was recorded following 10 min recovery. Repeated-measures ANOVA’s, 2 (trial) x 4 (time pt), showed significantly greater PO during RPE4 for CAF (130 ± 23 W) vs PLA (112 ± 26 W) and during RPE7 (CAF: 165 ± 37 vs PLA: 143 ± 41 W). Overall HR, VO2, and VE were significantly greater for CAF vs PLA during RPE7. RER for RPE4 and RPE7 were not significantly different (CAF vs PLA). Overall [La] was significantly greater for CAF during RPE4 (CAF: 2.32 ± 0.94 vs PLA: 1.73 ± 1.09) and RPE7 (CAF: 3.22 ± 1.44 vs PLA: 2.22 ± 1.49). Paired T-tests for S-RPE revealed no significant difference for RPE4 (CAF: 4.0 ± 0.5 vs PLA: 3.7 ± 0.5) or RPE7 (CAF: 7.1 ± 0.3 vs PLA: 6.9 ± 0.6) despite greater PO for CAF. Although individual responses varied, the current study indicates caffeine ingestion results in elevated self-selected PO with significant systematic changes in associated physiological responses particularly at a higher intensity (RPE7)

Three Week Hypergravity Training Intervention Decreases Ground Contact Time During Repeated Jumping and Improves Sprinting and Shuttle Running Performance

International Journal of Exercise Science 9(2): 149-158, 2016. This study examined the effects of a non-traditional training method, hypergravity training (HT), on anaerobic performance. Highly active men (n = 9) completed a 3 week HT protocol in which weighted vests were worn 8 h/day, 4+ days/week separate from training. Vest loads were 11.2 ± 0.6% of body mass during week one, and increased to 13.2 ± 0.7% (week 2), and 16.1 ± 0.4% (week 3). Performance testing included power clean 1-RM (PC), counter movement jumps, 4 continuous jumps, 36.6 m sprints (SP), a 137.2 m short shuttle run (SSR), and a 274.3 m long shuttle run (LSR). A 3 week non-hypergravity training period (NHT) proceeded HT. Baseline SP improved from 4.69 ± 0.29 s to 4.58 ± 0.22 s post-treatment, and regressed after NHT (4.69 ± 0.24 s) (p = 0.006, ES = 1.80). Improvements in SSR (p = 0.012, ES = 1.71) occurred from baseline (26.7 ± 1.5 s) to post-treatment (26.2 ± 1.4 s), followed by a return to near-baseline values (26.9 ± 1.8 s). Jumping tasks displayed similar trends, but no statistical differences and modest effect sizes (0.51 - 0.62) were found except for improved ground contact time during repeated jumps post-HT (ES = 2.26). PC and LSR performances did not improve. Three weeks of HT significantly enhanced short running task performances and decreased ground contact time between 4 continuous jumps. HT may be incorporated into training programs prior to key points in an athletic season without hindering the quality of regular training session activities

Can athletes be tough yet compassionate to themselves? Practical implications for NCAA mental health best practice no. 4

Recent tragic events and data from official NCAA reports suggest student-athletes’ wellbeing is compromised by symptoms of mental health (MH) disorders. Self-compassion (SC) and mental toughness (MT) are two psychological constructs that have been shown effective against stressors associated with sports. The purpose of this study was to investigate SC, MT, and MH in a NCAA environment for the first time and provide practical suggestions for MH best practice No.4. In total, 542 student-athletes participated across Divisions (Mage = 19.84, SD = 1.7). Data were collected through Mental Toughness Index, Self-Compassion Scale, and Mental Health Continuum–Short Form. MT, SC (including mindfulness), and MH were positively correlated. Males scored higher than females on all three scales. No differences were found between divisions. SC partially mediated the MT-MH relationship, but moderation was not significant. Working towards NCAA MH best practice should include training athletes in both MT and SC skills (via mindfulness)

Performance and perceptual responses of collegiate female soccer players to a practical external and internal cooling protocol

International Journal of Exercise Science 8(4): 331-340, 2015. This study examined practical pre- and mid practice cooling interventions on running performance, perceived exertion (RPE), and thermal sensation (TS) during soccer. During two formal pre-season practices female, NCAA Division II soccer players participated in three, 15 min scrimmage bouts followed by a 4th 10 min bout. Following the 1st, 2nd, and 3rd bouts, 8 field position players completed competitive sets of two, 30 yard sprints against other team members with time recorded between 5 and 30 yards. After the 4th bout, players completed an indoor shuttle running beep test (BT). In the treatment group (COOL) ice towels (IT) were applied to the head and neck regions and draped across both legs for 10 min following a standardized warm-up and for 10 min during a 15 min break between the 2nd and 3rd scrimmage sessions. Sport beverage slurries (350 mL; -0.3 °C, ~6% carbohydrate) were also served during IT cooling for COOL; while the control (CON) received no IT and drank the same ,uncooled sport beverage. No main effect was found for sprint performance (COOL = 3.55 ± 0.16 s; CON = 3.51 ± 0.07 s; P = 0.51) or numbers of reps completed in the BT (COOL = 17.6 ± 5.6; CON = 17.3 ± 6.0; P = 0.88). RPE did not differ following any performance test, but TS was lower following the 3rd sprint bout (P = 0.04) and the BT (P = 0.005) for COOL. COOL promoted lower TS, but had no effect on performance

Intrauterine death following intraamniotic triiodothyronine and thyroxine therapy for fetal goitrous hypothyroidism associated with polyhydramnios and caused by a thyroglobulin mutation

In the absence of maternal thyroid disease or iodine deficiency, fetal goitre is rare and usually attributable to dyshormonogenesis, for which genetic ascertainment is not always undertaken in the UK. Mechanical complications include tracheal and oesophageal compression with resultant polyhydramnios, malpresentation at delivery and neonatal respiratory distress. We report an Indian kindred in which the proband (first-born son) had congenital hypothyroidism (CH) without obvious neonatal goitre. His mother's second pregnancy was complicated by fetal hypothyroid goitre and polyhydramnios, prompting amniotic fluid drainage and intraamniotic therapy (with liothyronine, T3 and levothyroxine, T4). Sadly, intrauterine death occurred at 31 weeks. Genetic studies in the proband demonstrated compound heterozygous novel (c.5178delT, p.A1727Hfs*26) and previously described (c.7123G > A, p.G2375R) thyroglobulin (TG) mutations which are the likely cause of fetal goitre in the deceased sibling. TG mutations rarely cause fetal goitre, and management remains controversial due to the potential complications of intrauterine therapy however an amelioration in goitre size may be achieved with intraamniotic T4, and intraamniotic T3/T4 combination has achieved a favourable outcome in one case. A conservative approach, with surveillance, elective delivery and commencement of levothyroxine neonatally may also be justified, although intubation may be required post delivery for respiratory obstruction. Our observations highlight the lethality which may be associated with fetal goitre. Additionally, although this complication may recur in successive pregnancies, our case highlights the possibility of discordance for fetal goitre in siblings harbouring the same dyshormonogenesis-associated genetic mutations. Genetic ascertainment may facilitate prenatal diagnosis and assist management in familial cases. LEARNING POINTS: CH due to biallelic, loss-of-function TG mutations is well-described and readily treatable in childhood however mechanical complications from associated fetal goitre may include polyhydramnios, neonatal respiratory compromise and neck hyperextension with dystocia complicating delivery.CH due to TG mutations may manifest with variable phenotypes, even within the same kindred.Treatment options for hypothyroid dyshormogenic fetal goitre in a euthyroid mother include intraamniotic thyroid hormone replacement in cases with polyhydramnios or significant tracheal obstruction. Alternatively, cases may be managed conservatively with radiological surveillance, elective delivery and neonatal levothyroxine treatment, although intubation and ventilation may be required to support neonatal respiratory compromise.Genetic ascertainment in such kindreds may enable prenatal diagnosis and anticipatory planning for antenatal management of further affected offspring.This work was supported by funding from the Wellcome Trust (grant number 100585/Z/12/Z to N S) and the National Institute for Health Research Biomedical Research Centre Cambridge (N S). The Genomics/ Transcriptomics Core Facility is supported by the UK Medical Research Council (MRC) Metabolic Disease Unit (MRC_MC_UU_12012/5) and a Wellcome Trust Strategic Award (100574/Z/12/Z)

Comprehensive phenotypic analysis of the Dp1Tyb mouse strain reveals a broad range of down syndrome-related phenotypes

Down syndrome (DS), trisomy 21, results in many complex phenotypes including cognitive deficits, heart defects and craniofacial alterations. Phenotypes arise from an extra copy of human chromosome 21 (Hsa21) genes. However, these dosage-sensitive causative genes remain unknown. Animal models enable identification of genes and pathological mechanisms. The Dp1Tyb mouse model of DS has an extra copy of 63% of Hsa21-orthologous mouse genes. In order to establish if this model recapitulates DS phenotypes, we comprehensively phenotyped Dp1Tyb mice using 28 tests of different physiological systems and found that 468 out of 1800 parameters were significantly altered. We show that Dp1Tyb mice have wide-ranging DS-like phenotypes including aberrant erythropoiesis and megakaryopoiesis, reduced bone density, craniofacial changes, altered cardiac function, a pre-diabetic state and deficits in memory, locomotion, hearing and sleep. Thus, Dp1Tyb mice are an excellent model for investigating complex DS phenotype-genotype relationships for this common disorder

The occurrence of tarsal injuries in male mice of C57BL/6N substrains in multiple international mouse facilities.

Dislocation in hindlimb tarsals are being observed at a low, but persistent frequency in group-housed adult male mice from C57BL/6N substrains. Clinical signs included a sudden onset of mild to severe unilateral or bilateral tarsal abduction, swelling, abnormal hindlimb morphology and lameness. Contraction of digits and gait abnormalities were noted in multiple cases. Radiographical and histological examination revealed caudal dislocation of the calcaneus and partial dislocation of the calcaneoquartal (calcaneus-tarsal bone IV) joint. The detection, frequency, and cause of this pathology in five large mouse production and phenotyping centres (MRC Harwell, UK; The Jackson Laboratory, USA; The Centre for Phenogenomics, Canada; German Mouse Clinic, Germany; Baylor College of Medicine, USA) are discussed