Global Existence and Uniqueness of a Field Modelling the Thermal State of Three-dimensional Superconductor (1≤ N ≤ 3)

In this paper, we will study the global existence of a thermic field modelling the physical state of a three - dimensional superconductor. The superconductor is considered as a widely bounded regular field, with the usual physical data.In this paper, we will study the global existence of a thermic field modelling the physical state of a three - dimensional superconductor. The superconductor is considered as a widely bounded regular field, with the usual physical data

Equation Governing the Thermal State of a Superconductor with Nonlinear Thermophysical Coefficients: Existence and Uniqueness

The aim of this paper is to prove the existence and uniqueness of the problem's solution: Our basic idea is to adapt an approach coupling between two processes: 1. An iterative scheme that helps to exploit all the results obtained in [11][15]. 2.  A construction of solutions sequence (Un)nЄIN IN E, wich converges to the solution of the problem.The aim of this paper is to prove the existence and uniqueness of the problem's solution: Our basic idea is to adapt an approach coupling between two processes: 1. An iterative scheme that helps to exploit all the results obtained in [11][15]. 2.  A construction of solutions sequence (Un)nЄIN IN E, wich converges to the solution of the problem

Complex Multimodality Central Airway Management of Aspergillus Pseudomembranous Tracheobronchitis

A 69-year-old woman developed central airway obstruction due to invasive Aspergillus infection resulting in pseudomembranous tracheobronchitis (PTB). Several challenges were encountered in the airway management of this patient including her having relatively smaller airways which were more prone to obstruction by pseudomembranes and made airway interventions difficult. The patient had clinical deterioration in spite of antifungal therapy and bronchoscopic debridement. The multimodality airway techniques included the use of smaller biliary balloons for dilatation, using a hybrid stent to slowly dilate and maintain patency of right main stem and finally the insertion of right secondary carina peripheral Y stent, which resulted in clinical improvement and allowed time for antifungal therapy to take effect. To the best of our knowledge, the use of a peripheral Y stent has never been described in the setting of PTB

Comparative Investigation of Structure and Operating Parameters on the Performance and Reaction Dynamic of CO Conversion on Silica Aerogel and Fumed-Silica-Supported Pd Catalysts

The catalyst morphology, metal-support interaction, and reaction conditions greatly influence the catalytic performance and reaction dynamics. Similarly, the dispersion of the metal within the support plays a crucial role in the thermal stability and sintering of the catalyst. Furthermore, temperature-dependent conversion hysteresis is well-known to occur during ignition and extinction of exothermic CO oxidation over supported Pd catalysts due to the variation of CO adsorption on the surface or bulk oxidation of Pd and the ability of the catalyst to regenerate the active sites. Herein, the catalytic performance and the hysteresis behavior of mesoporous silica aerogel supported Pd (Pd/a-SiO2), and commercial fumed silica-supported Pd (Pd/f-SiO2) were investigated and compared using CO oxidation as a probe reaction under different reaction conditions and operating parameters (i.e., catalyst weight, ramp rate, and flow rate). Surface and morphologic examination using XPS, FTIR, and TEM of Pd/a-SiO2 and Pd/f-SiO2 reveal a strong correlation between the catalyst surface and structure and its catalytic performance and stability under different reaction parameters. Moreover, this study presents the effect of surface area, particle size, and size distribution on diffusion and mass transport of reactants (CO, O2) and products (CO2) and active sites accessibility. This study showed that Pd/f-SiO2 had better efficiency under high (turbulence) flow. Moreover, intrinsic apparent activation energy (Ea) and the number of active sites were calculated from the Kinetics of CO oxidation fitted using Arrhenius plots indicate that the ramp rate has less effect on Pd/f-SiO2 catalytic behavior. Even though, Pd/f-SiO2 had higher relative active sites than Pd/a-SiO2, (Ea) was lower. Cyclic stability and long-term stabilities showed that both catalysts are stable and can regenerate the active sites. The current study contributes to understanding the catalysts\u27 surface, structural and morphological properties on the catalysts\u27 performance toward CO oxidation and other reactions under dynamic conditions

Synthesis and SomeReactions of 3-Methyl-4-aryl-1-phenyl-1H- pyrazolo[3,4-dipyrimidine-6-thiols

3-Methyl-4-aryl-1-phenyl-1H -pyrazolo[3,4-d]-pyrimidine-6-thiols( 11)were synthesised by the raction of thiourea with 3-methyl-\u27 -1-phenyl-4-arylidene-2-pyrazolin-5-ones(1) in ethanolic solution of potassium hydroxide. The mechanism of this reaction is discussed and further transformation of the products with different reagents (S-methylation, substitution of SR-group by arylamines, hydrazine, and azide) was carried out

Synthesis of Fused Heterocyclic Derivatives from 5-Ethyl-3-Hydrazino-5H-1,2,4-Triazino[5,6-b]Indole

5-Ethyl-3-hydrazino-5H-1,2,4-triazino[5,6-b ]indole II was used for the synthesis of various heterocyclic derivatives. This was performed by reaction of its 3-hydrazino group with different reagents such as acid anhydrides, ethylacetate, diethyl oxalate, thioglycolic acid, aroyl esters and acid chlorides. The structure of the products was confirmed by different spectroscopic and analytical methods

The Middle Atlas Geological karsts forms: Towards Geosites characterization

International audienceRich limestone Jurassic formations and huge water reservoir are natural characteristics of the Middle Atlas Chain in Morocco, which, therefore, offers geodiversity of karst geosystems. The geological, tectonic and hydro-geo-morphological nature of the history of Atlas orogeny has affected the eastern part of the Middle, ensuring the evolution of karst features on various sites of this zone. This study presents some touristic offers specific to the Middle Atlas, particularly in terms of genesis, structures, and functions that could develop and promote public tourism offers. It argues that this development depends on future geological funds identification and classification as Geosites. On the basis of the patrimonial process characterising the Middle Atlas, this study suggests the creation of a Geopark in the Middle Atlas, within the framework of the evaluation criteria of the UNESCO. The implementation of this suggestion would contribute to the socioeconomic development of this region of Morocco

TREATMENT OF SHIZOPHRENIC PATIENTS AND rTMS

Introduction: Schizophrenia (SCH) is a heterogeneous syndrome characterized by positive and negative symptoms. Despite appropriate medication, about 1/4 of patients suffer for refractory positive and/or negative symptoms, which are associated with functional handicap, increase of duration and of the number of hospitalizations. Numerous studies have suggested that the pathophysiology of auditory hallucinations (AH) is related to a hyper activity of the left temporoparietal cortex (TPC). On the other hand, negative symptoms are associated with a prefrontal hypoactivity and the efficiency of pharmacological treatments is frequently partial. Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive brain stimulation tool with excellent tolerability and safety. Given its hypothesized mechanisms of action and the clinical beneficial effects obtained in several types of pathology (Aleman et al. 2007), the efficacy of rTMS has been investigated for drug-resistant SCH symptoms. Objective: Our objective is to expose the knowledge concerning the rTMS use in the treatment of these symptoms and to purpose a critical analysis of these data. Method: a systematic review of the literature has been conducted using NIH Pubmed. The following search terms were used: TMS - rTMS - Schizophrenia - negative symptoms - hallucinations. Results: Concerning the treatment of AH, 16 publications and 4 meta analyses were selected. For the negative symptoms, we retained 16 studies and 3 meta analyses. The most extensively investigated application for rTMS in SCH is the use of low-frequency stimulation to the left TPC with the aim to improve AH symptomatology. When compared to sham, this type of acute course of rTMS has been proven to induce a substantial and significant reduction in AH. But this effect does not seem long-lasting and maintenance protocols must be developed. Concerning negative symptoms, the results are less solid but we find some works which demonstrate an improvement of these symptoms while various stimulation parameters were used. Recently, new parameters of stimulation in particular the theta burst stimulation have permitted us to obtain larger effects with longer duration. The interest of these new parameters will be discussed here. Conclusion: Overall, rTMS studies have demonstrated some promise in the treatment of SCH. However, more research is required to enhance rTMS efficacy and increase its beneficial effect duration and to test new therapeutic strategies in this topic

TREATMENT OF SHIZOPHRENIC PATIENTS AND rTMS

Introduction: Schizophrenia (SCH) is a heterogeneous syndrome characterized by positive and negative symptoms. Despite appropriate medication, about 1/4 of patients suffer for refractory positive and/or negative symptoms, which are associated with functional handicap, increase of duration and of the number of hospitalizations. Numerous studies have suggested that the pathophysiology of auditory hallucinations (AH) is related to a hyper activity of the left temporoparietal cortex (TPC). On the other hand, negative symptoms are associated with a prefrontal hypoactivity and the efficiency of pharmacological treatments is frequently partial. Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive brain stimulation tool with excellent tolerability and safety. Given its hypothesized mechanisms of action and the clinical beneficial effects obtained in several types of pathology (Aleman et al. 2007), the efficacy of rTMS has been investigated for drug-resistant SCH symptoms. Objective: Our objective is to expose the knowledge concerning the rTMS use in the treatment of these symptoms and to purpose a critical analysis of these data. Method: a systematic review of the literature has been conducted using NIH Pubmed. The following search terms were used: TMS - rTMS - Schizophrenia - negative symptoms - hallucinations. Results: Concerning the treatment of AH, 16 publications and 4 meta analyses were selected. For the negative symptoms, we retained 16 studies and 3 meta analyses. The most extensively investigated application for rTMS in SCH is the use of low-frequency stimulation to the left TPC with the aim to improve AH symptomatology. When compared to sham, this type of acute course of rTMS has been proven to induce a substantial and significant reduction in AH. But this effect does not seem long-lasting and maintenance protocols must be developed. Concerning negative symptoms, the results are less solid but we find some works which demonstrate an improvement of these symptoms while various stimulation parameters were used. Recently, new parameters of stimulation in particular the theta burst stimulation have permitted us to obtain larger effects with longer duration. The interest of these new parameters will be discussed here. Conclusion: Overall, rTMS studies have demonstrated some promise in the treatment of SCH. However, more research is required to enhance rTMS efficacy and increase its beneficial effect duration and to test new therapeutic strategies in this topic

Albatrellus confluens (Alb. & Schwein.) Kotl. & Pouz.: natural fungal compounds and synthetic derivatives with in vitro anthelmintic activities and antiproliferative effects against two human cancer cell lines

Neglected tropical diseases affect the world's poorest populations with soil-transmitted helminthiasis and schistosomiasis being among the most prevalent ones. Mass drug administration is currently the most important control measure, but the use of the few available drugs is giving rise to increased resistance of the parasites to the drugs. Different approaches are needed to come up with new therapeutic agents against these helminths. Fungi are a source of secondary metabolites, but most fungi remain largely uninvestigated as anthelmintics. In this report, the anthelmintic activity of Albatrellus confluens against Caenorhabditis elegans was investigated using bio-assay guided isolation. Grifolin (1) and neogrifolin (2) were identified as responsible for the anthelmintic activity. Derivatives 4-6 were synthesized to investigate the effect of varying the prenyl chain length on anthelmintic activity. The isolated compounds 1 and 2 and synthetic derivatives 4-6, as well as their educts 7-10, were tested against Schistosoma mansoni (adult and newly transformed schistosomula), Strongyloides ratti, Heligmosomoides polygyrus, Necator americanus, and Ancylostoma ceylanicum. Prenyl-2-orcinol (4) and geranylgeranyl-2-orcinol (6) showed promising activity against newly transformed schistosomula. The compounds 1, 2, 4, 5, and 6 were also screened for antiproliferative or cytotoxic activity against two human cancer lines, viz. prostate adenocarcinoma cells (PC-3) and colorectal adenocarcinoma cells (HT-29). Compound 6 was determined to be the most effective against both cell lines with IC50 values of 16.1 microM in PC-3 prostate cells and 33.7 microM in HT-29 colorectal cells