M.leprae binds to a 28-30 kDa phosphorylated glycoprotein of rat peripheral nerve

This article does not have an abstract

MAXIMUM DATA RATE DETERMINATION OF A TELEPHONE TRANSMISSION CHANNEL

The transmission channel is an electrical medium that bridges the distance from the source to the destination. It may be apair of wires, a coaxial cable, a radio path, or an optical fiber. Every channel introduces some amount of transmission loss orattenuation and, therefore, the transmitted power progressively decreases with increasing distance. The signal is alsodistorted in the transmission channel because of different attenuation at different frequencies. Signals usually containcomponents at many frequencies and if some are attenuated and some are not, the shape of the signal changes. This change isknown as distortion. Note that a transmission channel often includes many speech or data channels that are multiplexed intothe same cable pair or fiber. In this paper we present the determination of maximum data rate of a telephone channel.Keywords: Bandwidth, Data Rate, Symbol Rate, Transmission Channe

A STUDY ON WEALTH MANAGEMENT AND CLIENT INVESTMENT SERVICE, BANGALORE

Wealth management and client investment services are essential components of the financial industry, catering to the complex and diverse needs of clients seeking to grow, preserve, and manage their wealth. Whether through personalized advisory services or technology-driven solutions, the overarching goal is to provide clients with a path toward financial security and prosperity. the evolving landscape of wealth management, with a particular emphasis on the fusion of traditional and digital service models. This dynamic environment offers clients a range of options to suit their preferences and adapt to changing market conditions. The fundamental concepts and principles that under pin the wealth management and client investment services landscape, shedding light on the paramount importance of aligning financial strategies with clients' unique goals, risk tolerances, and investment time horizons. Furthermore, this abstract highlights the ongoing transformation within wealth management, especially the convergence of traditional and digital service models, catering to clients' diverse preferences and adapting to a rapidly changing economic and regulatory environment. Wealth management's changing environment, with a focus on the blending of traditional and digital service approaches. Customers have a variety of options in this dynamic environment to fit their interests and adjust to shifting market conditions. The core ideas and principles that guide wealth management and client investment services, emphasizing the critical role that matching financial strategies to customers' individual objectives, risk tolerances, and time horizons plays in their success. In order to meet the complicated and varied demands of clients looking to increase, maintain, and manage their wealth, client investment services and wealth management are crucial elements of the financial sector. The main objective is to offer clients a route toward financial security and prosperity, whether through individualized consulting services or technology-driven solutions. In addition, this emphasizes the ongoing transition in wealth management, particularly the fusion of traditional and digital service models, addressing the varied preferences of customers, and adjusting to a quickly altering regulatory and economic environment

Evaluation of nutrient management for better growth, yield and economics of fenugreek

A field experiment was conducted to study the effect of nutrient management combinations in fenugreek (Trigonella foenum-graecum). Growth as well as seed and straw yields of fenugreek were significantly influenced by different treatments. Application of recommended dose through inorganic form (50%) + neem cake @ 638 kg ha-1 + Rhizobium melilotii + phosphate solubilising bacteria (PSB) recorded the highest plant height of 34.98 cm, leaves of 82.35 and branches of 5.5 at the final harvest stage. This treatment also recorded significantly highest straw yields. The maximum seed yield, net returns and benefit cost ratio were obtained in the combination of 50% recommended dose of fertilizer (RDF) + poultry manure (PM) @1000 kg ha-1 + Rhizobium melilotii + phosphate solubilising bacteria (PSB). &nbsp

Serological responses to prednisolone treatment in leprosy reactions: study of TNF-α, antibodies to phenolic glycolipid-1, lipoarabinomanan, ceramide and S100-B.

BACKGROUND: Corticosteroids have been extensively used in the treatment of immunological reactions and neuritis in leprosy. The present study evaluates the serological response to steroid treatment in leprosy reactions and neuritis. METHODS: Seven serological markers [TNF-α, antibodies to Phenolic glycolipid-1 (PGL-1 IgM and IgG), Lipoarabinomannan (LAM IgG1 and IgG3), C2-Ceramide and S100 B] were analyzed longitudinally in 72 leprosy patients before, during and after the reaction. At the onset of reaction these patients received a standard course of prednisolone. The levels of the above markers were measured by Enzyme linked immunosorbent assay (ELISA) and compared with the individuals own value in the month prior to the reaction and presented as percentage increase. RESULTS: One month before the reaction individuals showed a varying increase in the level of different markers such as TNF-α (53%) and antibodies to Ceramide (53%), followed by to PGL-1 (51%), S100B (50%) and LAM (26%). The increase was significantly associated with clinical finding of nerve pain, tenderness and new nerve function impairment. After one month prednisolone therapy, there was a fall in the levels [TNF-α (60%), C2-Ceramide (54%), S100B (67%), PGL-1(47%) and LAM (52%)] with each marker responding differently to steroid. CONCLUSION: Reactions in leprosy are inflammatory processes wherein a rise in set of serological markers can be detected a month before the clinical onset of reaction, some of which remain elevated during their action and steroid treatment induces a variable fall in the levels, and this forms the basis for a variable individual response to steroid therapy

Cytokine and Protein Markers of Leprosy Reactions in Skin and Nerves: Baseline Results for the North Indian INFIR Cohort

Leprosy affects skin and peripheral nerves. Although we have effective antibiotics to treat the mycobacterial infection, a key part of the disease process is the accompanying inflammation. This can worsen after starting antibacterial treatment with episodes of immune mediated inflammation, so called ‘reactions’. These reactions are associated with worsening of the nerve damage. We recruited a cohort of 303 newly diagnosed leprosy patients in North India with the aim of understanding and defining the pathological processes better. We took skin and nerve biopsies from patients and examined them to define which molecules and mediators of inflammation were present. We found high levels of the cytokines Tumour Necrosis Factor alpha, Transforming Growth Factor beta and inducible Nitric Oxide Synthase in biopsies from patients with reactions. We also found high levels of bacteria and inflammation in the nerves. These experiments tell us that we need to determine which other molecules are present and to explore ways of switching off the production of these pro-inflammatory molecules

Women’s Empowerment Mitigates the Negative Effects of Low Production Diversity on Maternal and Child Nutrition in Nepal

We use household survey data from Nepal to investigate relationships between women’s empowerment in agriculture and production diversity on maternal and child dietary diversity and anthropometric outcomes. Production diversity is positively associated with maternal and child dietary diversity, and weight-for-height z-scores. Women’s group membership, control over income, reduced workload, and overall empowerment are positively associated with better maternal nutrition. Control over income is positively associated with height-for-age z-scores (HAZ), and a lower gender parity gap improves children’s diets and HAZ. Women’s empowerment mitigates the negative effect of low production diversity on maternal and child dietary diversity and HAZ

Improvement of two traditional Basmati rice varieties for bacterial blight resistance and plant stature through morphological and marker-assisted selection

Bacterial blight (BB) is a major production threat to Basmati, the aromatic rice prized for its unique quality. In order to improve the BB resistance of two elite, traditional BB-susceptible Basmati varieties (Taraori Basmati and Basmati 386), we utilized the strategy of limited marker-assisted backcrossing for introgression of two major BB resistance genes, Xa21 and xa13, coupled with phenotype-based selection for improvement of their plant type and yield. Improved Samba Mahsuri, an elite high-yielding, fine-grain-type BB-resistant rice variety served as donor for BB resistance. Backcross-derived improved Basmati lines at BC1F5 possessing a single resistance gene (i.e. either Xa21 or xa13) displayed moderate resistance to BB, while lines possessing both Xa21 and xa13 showed significantly higher levels of resistance. Two-gene pyramid lines (Xa21 + xa13) possessing good grain and cooking quality similar to their respective traditional Basmati parents, short plant stature (<110 cm plant height) and higher grain yield than the recurrent parent(s) were identified and advanced. This work demonstrates the successful application of marker-assisted selection in conjunction with phenotype-based selection for targeted introgression of multiple resistance genes into traditional Basmati varieties along with improvement of their plant stature and yield

Improving risk models for patients having emergency bowel cancer surgery using linked electronic health records: a national cohort study

BACKGROUND: Life-saving emergency major resection of colorectal cancer (CRC) is a high-risk procedure. Accurate prediction of post-operative mortality for patients undergoing this procedure is essential for both healthcare performance monitoring and pre-operative risk assessment. Risk-adjustment models for CRC patients often include patient and tumour characteristics, widely available in cancer registries and audits. We investigated to what extent inclusion of additional physiological and surgical measures, available through linkage or additional data collection, improves accuracy of risk models. METHODS: Linked, routinely-collected data on patients undergoing emergency CRC surgery in England between December 2016 and November 2019 were used to develop a risk model for 90-day mortality. Backwards selection identified a 'selected model' of physiological and surgical measures in addition to patient and tumour characteristics. Model performance was assessed compared to a 'basic model' including only patient and tumour characteristics. Missing data was multiply imputed. RESULTS: 846 of 10,578 (8.0%) patients died within 90 days of surgery. The selected model included seven pre-operative physiological and surgical measures (pulse rate, systolic blood pressure, breathlessness, sodium, urea, albumin, and predicted peritoneal soiling), in addition to the ten patient and tumour characteristics in the basic model (calendar year of surgery, age, sex, ASA grade, TNM T stage, TNM N stage, TNM M stage, cancer site, number of comorbidities, emergency admission). The selected model had considerably better discrimination compared to the basic model (C-statistic: 0.824 versus 0.783, respectively). CONCLUSION: Linkage of disease-specific and treatment-specific datasets allowed the inclusion of physiological and surgical measures in a risk model alongside patient and tumour characteristics which improves the accuracy of the prediction of the mortality risk for CRC patients having emergency surgery. This improvement will allow more accurate performance monitoring of healthcare providers and enhance clinical care planning

Comparing the Clinical and Histological Diagnosis of Leprosy and Leprosy Reactions in the INFIR Cohort of Indian Patients with Multibacillary Leprosy

Leprosy affects skin and peripheral nerves. Although we have antibiotics to treat the mycobacterial infection, the accompanying inflammation is a major part of the disease process. This can worsen after starting antibacterial treatment with episodes of immune mediated inflammation, so called reactions. These are associated with worsening of nerve damage. However, diagnosing these reactions is not straightforward. They can be diagnosed clinically by examination or by microscopic examination of the skin biopsies. We studied a cohort of 303 newly diagnosed leprosy patients in India and compared the diagnosis rates by clinical examination and microscopy and found that the microscopic diagnosis has higher rates of diagnosis for both types of reaction. This suggests that clinicians and pathologists have different thresholds for diagnosing reactions. More work is needed to optimise both clinical and pathological diagnosis. In this cohort 43% of patients had Borderline Tuberculoid leprosy, an immunologically active type, and 20% of the biopsies showed only minimal inflammation, perhaps these patients had very early disease or self-healing. The public health implication of this work is that leprosy centres need to be supported by pathologists to help with the clinical management of difficult cases