Extracting Physician Group Intelligence from Electronic Health Records to Support Evidence Based Medicine

Evidence-based medicine employs expert opinion and clinical data to inform clinical decision making. The objective of this study is to determine whether it is possible to complement these sources of evidence with information about physician “group intelligence” that exists in electronic health records. Specifically, we measured laboratory test “repeat intervals”, defined as the amount of time it takes for a physician to repeat a test that was previously ordered for the same patient. Our assumption is that while the result of a test is a direct measure of one marker of a patient's health, the physician's decision to order the test is based on multiple factors including past experience, available treatment options, and information about the patient that might not be coded in the electronic health record. By examining repeat intervals in aggregate over large numbers of patients, we show that it is possible to 1) determine what laboratory test results physicians consider “normal”, 2) identify subpopulations of patients that deviate from the norm, and 3) identify situations where laboratory tests are over-ordered. We used laboratory tests as just one example of how physician group intelligence can be used to support evidence based medicine in a way that is automated and continually updated

Structure Formation Inside Triaxial Dark Matter Halos: Galactic Disks, Bulges and Bars

We investigate the formation and evolution of galactic disks immersed in assembling live DM halos. Disk/halo components have been evolved from the cosmological initial conditions and represent the collapse of an isolated density perturbation. The baryons include gas (which participates in star formation [SF]) and stars. The feedback from the stellar energy release onto the ISM has been implemented. We find that (1) The growing triaxial halo figure tumbling is insignificant and the angular momentum (J) is channeled into the internal circulation; (2) Density response of the disk is out of phase with the DM, thus diluting the inner halo flatness and washing out its prolateness; (3) The total J is neathly conserved, even in models accounting for feedback; (4) The specific J for the DM is nearly constant, while that for baryons is decreasing; (5) Early stage of disk formation resembles the cat's cradle -- a small amorphous disk fueled via radial string patterns; (6) The initially puffed up gas component in the disk thins when the SF rate drops below ~5 Mo/yr; (7) About 40%-60% of the baryons remain outside the SF region; (8) Rotation curves appear to be flat and account for the observed disk/halo contributions; (9) A range of bulge-dominated to bulgeless disks was obtained; Lower density threshold for SF leads to a smaller, thicker disk; Gravitational softening in the gas has a substantial effect on various aspects of galaxy evolution and mimics a number of intrinsic processes within the ISM; (10) The models are characterized by an extensive bar-forming activity; (11) Nuclear bars, dynamically coupled and decoupled form in response to the gas inflow along the primary bars.Comment: 18 pages, 16 figures, accepted by the Astrophysical Journal. Minor revisions. The high-resolution figures can be found at http://www.pa.uky.edu/~shlosman/research/galdyn/figs07a

Stellar Bar Evolution in Cuspy and Flat-Cored Triaxial CDM Halos

We analyze the evolution of stellar bars in galactic disks in mildly triaxial flat-core and cuspy CDM halos. We use tailored simulations of rigid and live halos which include the feedback from disk/bar onto the halo in order to test the work by El-Zant & Shlosman (2002). The latter used the Liapunov exponents to analyze the fate of bars in analytical asymmetric halos. We find: (1) The bar growth is similar in all rigid axisymmetric and triaxial halos. (2) Bars in live models vertically buckle and form a pseudobulge with a boxy/peanut shape. (3) In live axisymmetric halos, the bar strength varies little during the secular evolution. The bar pattern speed anticorrelates with the halo core size. The bar strength is larger for smaller disk-to-halo mass ratios within disk radii, the bar size correlates with the halo core sizes, and the bar pattern speeds -- with the halo central mass concentration. Bars embedded in live triaxial halos have a starkly different fate: they dissolve on ~1.5-5 Gyr due to the onset of chaos over continuous zones, leaving behind a weak oval distortion. The onset of chaos is related to the halo triaxiality, the fast rotating bar and the halo cuspiness. Before the bar dissolves, the region outside it develops strong spiral structures, especially in the live triaxial halos. (4) More angular momentum is absorbed by the triaxial halos as compared to the axisymmetric models and its exchange is mediated by resonances. (5) Cuspy halos are more susceptible than flat-core halos to having their prolateness washed out by the bar. We analyze these results in terms of the stability of trajectories and development of chaos. We set constraints on the triaxiality of DM halos by comparing our predictions to recent observations of bars out to z~1.Comment: 17 pages, 14 figures, Astrophysical Journal, in press, Vol. 637. Updated version (text, references

Nuclear Magnetic Resonance Quantum Computing Using Liquid Crystal Solvents

Liquid crystals offer several advantages as solvents for molecules used for nuclear magnetic resonance quantum computing (NMRQC). The dipolar coupling between nuclear spins manifest in the NMR spectra of molecules oriented by a liquid crystal permits a significant increase in clock frequency, while short spin-lattice relaxation times permit fast recycling of algorithms, and save time in calibration and signal-enhancement experiments. Furthermore, the use of liquid crystal solvents offers scalability in the form of an expanded library of spin-bearing molecules suitable for NMRQC. These ideas are demonstrated with the successful execution of a 2-qubit Grover search using a molecule ($^{13}$C$^{1}$HCl$_3$) oriented in a liquid crystal and a clock speed eight times greater than in an isotropic solvent. Perhaps more importantly, five times as many logic operations can be executed within the coherence time using the liquid crystal solvent.Comment: Minor changes. Published in Appl. Phys. Lett. v.75, no.22, 29 Nov 1999, p.3563-356

Encoding One Logical Qubit Into Six Physical Qubits

We discuss two methods to encode one qubit into six physical qubits. Each of our two examples corrects an arbitrary single-qubit error. Our first example is a degenerate six-qubit quantum error-correcting code. We explicitly provide the stabilizer generators, encoding circuit, codewords, logical Pauli operators, and logical CNOT operator for this code. We also show how to convert this code into a non-trivial subsystem code that saturates the subsystem Singleton bound. We then prove that a six-qubit code without entanglement assistance cannot simultaneously possess a Calderbank-Shor-Steane (CSS) stabilizer and correct an arbitrary single-qubit error. A corollary of this result is that the Steane seven-qubit code is the smallest single-error correcting CSS code. Our second example is the construction of a non-degenerate six-qubit CSS entanglement-assisted code. This code uses one bit of entanglement (an ebit) shared between the sender and the receiver and corrects an arbitrary single-qubit error. The code we obtain is globally equivalent to the Steane seven-qubit code and thus corrects an arbitrary error on the receiver's half of the ebit as well. We prove that this code is the smallest code with a CSS structure that uses only one ebit and corrects an arbitrary single-qubit error on the sender's side. We discuss the advantages and disadvantages for each of the two codes.Comment: 13 pages, 3 figures, 4 table

Cavity approach for real variables on diluted graphs and application to synchronization in small-world lattices

We study XY spin systems on small world lattices for a variety of graph structures, e.g. Poisson and scale-free, superimposed upon a one dimensional chain. In order to solve this model we extend the cavity method in the one pure-state approximation to deal with real-valued dynamical variables. We find that small-world architectures significantly enlarge the region in parameter space where synchronization occurs. We contrast the results of population dynamics performed on a truncated set of cavity fields with Monte Carlo simulations and find excellent agreement. Further, we investigate the appearance of replica symmetry breaking in the spin-glass phase by numerically analyzing the proliferation of pure states in the message passing equations.Comment: 10 pages, 3 figure

Density Waves Inside Inner Lindblad Resonance: Nuclear Spirals in Disk Galaxies

We analyze formation of grand-design two-arm spiral structure in the nuclear regions of disk galaxies. Such morphology has been recently detected in a number of objects using high-resolution near-infrared observations. Motivated by the observed (1) continuity between the nuclear and kpc-scale spiral structures, and by (2) low arm-interarm contrast, we apply the density wave theory to explain the basic properties of the spiral nuclear morphology. In particular, we address the mechanism for the formation, maintenance and the detailed shape of nuclear spirals. We find, that the latter depends mostly on the shape of the underlying gravitational potential and the sound speed in the gas. Detection of nuclear spiral arms provides diagnostics of mass distribution within the central kpc of disk galaxies. Our results are supported by 2D numerical simulations of gas response to the background gravitational potential of a barred stellar disk. We investigate the parameter space allowed for the formation of nuclear spirals using a new method for constructing a gravitational potential in a barred galaxy, where positions of resonances are prescribed.Comment: 18 pages, 9 figures, higher resolution available at http://www.pa.uky.edu/~ppe/papers/nucsp.ps.g