Acylsulfonamide safety-catch linker : promise and limitations for solid-phase oligosaccharide synthesis

Safety-catch linkers are useful for solid-phase oligosaccharide synthesis as they are orthogonal to many common protective groups. A new acylsulfonamide safety-catch linker was designed, synthesized and employed during glycosylations using an automated carbohydrate synthesizer. The analysis of the cleavage products revealed shortcomings for oligosaccharide synthesis

Six-body Light-Front Tamm-Dancoff approximation and wave functions for the massive Schwinger model

The spectrum of the massive Schwinger model in the strong coupling region is obtained by using the light-front Tamm-Dancoff (LFTD) approximation up to including six-body states. We numerically confirm that the two-meson bound state has a negligibly small six-body component. Emphasis is on the usefulness of the information about states (wave functions). It is used for identifying the three-meson bound state among the states below the three-meson threshold. We also show that the two-meson bound state is well described by the wave function of the relative motion.Comment: 19 pages, RevTeX, 7 figures are available upon request; Minor errors have been corrected; Final version to appear in Phys.Rev.

Calculation of production and decay of radioisotopes for future irradiation experiments and ion beam facilities

Abstract.: The design of future radioactive ion beam (RIB) facilites requires the forecast of radio isotope inventory after irradiation. At CERN - ISOLDE, we developed a software that estimates the activity of irradiated materials as a function of time dedicated to radioactive waste management. This tool can also be used for licensing procedures, planning of irradiation experiments and the estimation of yield

ERTS-1 applications to Minnesota land use mapping

Land use class definitions that can be operationally employed with ERTS-1 imagery are being developed with the cooperation of personnel from several state, regional, and federal agencies with land management responsibilities within the state and the University of Minnesota. Investigations of urban, extractive, forest, and wetlands areas indicate that it is feasible to subdivide each of these classes into several sub-classes with the use of ERTS-1 images from one or more time periods

Sonoluminescing air bubbles rectify argon

The dynamics of single bubble sonoluminescence (SBSL) strongly depends on the percentage of inert gas within the bubble. We propose a theory for this dependence, based on a combination of principles from sonochemistry and hydrodynamic stability. The nitrogen and oxygen dissociation and subsequent reaction to water soluble gases implies that strongly forced air bubbles eventually consist of pure argon. Thus it is the partial argon (or any other inert gas) pressure which is relevant for stability. The theory provides quantitative explanations for many aspects of SBSL.Comment: 4 page

Dynamics of the Light-Cone Zero Modes: Theta Vacuum of the Massive Schwinger Model

The massive Schwinger model is quantized on the light cone with great care on the bosonic zero modes by putting the system in a finite (light-cone) spatial box. The zero mode of $A_{-}$ survives Dirac's procedure for the constrained system as a dynamical degree of freedom. After regularization and quantization, we show that the physical space condition is consistently imposed and relates the fermion Fock states to the zero mode of the gauge field. The vacuum is obtained by solving a Schr\"odinger equation in a periodic potential, so that the theta is understood as the Bloch momentum. We also construct a one-meson state in the fermion-antifermion sector and obtained the Schr\"odinger equation for it.Comment: 23 pages, RevTex, no figure

Diagnostic Role of Chromosomal Instability in Melanoma

Early diagnosis gives melanoma patients the best chance for long term survival. However discrimination of an early melanoma from an unusual/atypical benign nevus can represent a significant challenge. There are no current pathological markers to definitively define malignant potential in these indeterminate lesions. Thus, there is a need for improved diagnostic tools. Chromosomal instability (CIN) is a hallmark of cancer and is markedly prevalent in melanoma. Advances in genomics have opened the door for the development of molecular tools to better segregate benign and malignant lesions. This paper focuses on CIN in melanoma and the role of current diagnostic approaches

Zero Mode and Symmetry Breaking on the Light Front

We study the zero mode and the spontaneous symmetry breaking on the light front (LF). We use the discretized light-cone quantization (DLCQ) of Maskawa-Yamawaki to treat the zero mode in a clean separation from all other modes. It is then shown that the Nambu-Goldstone (NG) phase can be realized on the trivial LF vacuum only when an explicit symmetry-breaking mass of the NG boson $m_{\pi}$ is introduced. The NG-boson zero mode integrated over the LF must exhibit singular behavior $\sim 1/m_{\pi}^2$ in the symmetric limit $m_{\pi}\to 0$, which implies that current conservation is violated at zero mode, or equivalently the LF charge is not conserved even in the symmetric limit. We demonstrate this peculiarity in a concrete model, the linear sigma model, where the role of zero-mode constraint is clarified. We further compare our result with the continuum theory. It is shown that in the continuum theory it is difficult to remove the zero mode which is not a single mode with measure zero but the accumulating point causing uncontrollable infrared singularity. A possible way out within the continuum theory is also suggested based on the ``$\nu$ theory''. We finally discuss another problem of the zero mode in the continuum theory, i.e., no-go theorem of Nakanishi-Yamawaki on the non-existence of LF quantum field theory within the framework of Wightman axioms, which remains to be a challenge for DLCQ, ``$\nu$ theory'' or any other framework of LF theory.Comment: 60 pages, the final section has been expanded. A few minor corrections; version to be published in Phys. Rev.