Lixiviação de nutrientes em substrato enriquecido com biochar.

Resumo

Guia para identificação dos principais solos do Estado do Paraná.

Conceitos e definições; Principais solos do Estado do Paraná.bitstream/item/36228/1/Guia-para-identificacao.pd

Explaining variability in early stages of [18F]-flortaucipir tau-PET binding: Focus on sex differences

INTRODUCTION Female sex is associated with increased [18F]-flortaucipir signal, which may be affected by amyloid pathology, age, and off-target binding in skull and meninges. METHODS In this cross-sectional study comprising 52 females and 52 matched males, we examined sex-related differences in regional tau-positron emission tomography (PET) with and without considering off-target binding. We assessed the respective contributions of sex, age, amyloid-PET burden, and off-target binding to tau-PET signal. We explored associations between age at menopause and hormone replacement therapy (HRT) use with regional tau-PET signals. RESULTS Female sex was associated with increased regional tau both independently and interactively with amyloid, but amyloid-independent associations were largely reduced when controlling for off-target binding. Age but not age*sex interactions explained a small but significant amount of tau-PET signal in temporoparietal regions. Considering the sample size and limited range of amyloid-PET burden, no clear associations between regional tau-PET signals and age at menopause or HRT use could be found. DISCUSSION Female sex is associated with increased [18F]-flortaucipir signal mainly through its interaction with amyloid

Conexiones entre las características sensoriales y la información que proporcionan los tests de estabilidad del aceite de soja

The relationship between sensorial deterioration (shelf-life) and induction period of refined soybean oil was studied, according to data obtained with the Rancimat method and peroxide value during 190 days of storage of the sample at room temperature. The Rancimat curve was obtained at 110 ºC, 10 l/h of air flow and 5,0 g of sample and showed an induction period of 6.75 h. From the variation of the peroxide value the induction period was 107 days, equivalent to 6,4 meg/kg. The sensorial analysis was carried out by a well trained panel which established that the sensorial deterioration of the sample was 102 days.<br><br>Se estudió la relación existente entre el deterioro sensorial (vida útil) del aceite de soja y el tiempo de inducción de la oxidación, según datos obtenidos con el Rancimat y la variación del índice de peróxidos durante el almacenamiento del aceite a lo largo de 190 días a temperatura ambiente. La curva del Rancimat se calculó a 110°C con flujo de aire de 101/ h, 5,0 g de muestra, resultando un período de inducción de 6,75 h. Según la variación del índice de peróxidos, el período de inducción resultó de 107 días, equivalente a 6,4 meq/kg. El análisis sensorial estuvo a cargo de catadores quienes establecieron que el deterioro sensorial se producía a los 102 días

Conexiones entre las características sensoriales y la información que proporcionan los tests de estabilidad del aceite de soja

The relationship between sensorial deterioration (shelf-life) and induction period of refined soybean oil was studied, according to data obtained with the Rancimat method and peroxide value during 190 days of storage of the sample at room temperature. The Rancimat curve was obtained at 110 ºC, 10 l/h of air flow and 5,0 g of sample and showed an induction period of 6.75 h. From the variation of the peroxide value the induction period was 107 days, equivalent to 6,4 meg/kg. The sensorial analysis was carried out by a well trained panel which established that the sensorial deterioration of the sample was 102 days.Se estudió la relación existente entre el deterioro sensorial (vida útil) del aceite de soja y el tiempo de inducción de la oxidación, según datos obtenidos con el Rancimat y la variación del índice de peróxidos durante el almacenamiento del aceite a lo largo de 190 días a temperatura ambiente. La curva del Rancimat se calculó a 110°C con flujo de aire de 101/ h, 5,0 g de muestra, resultando un período de inducción de 6,75 h. Según la variación del índice de peróxidos, el período de inducción resultó de 107 días, equivalente a 6,4 meq/kg. El análisis sensorial estuvo a cargo de catadores quienes establecieron que el deterioro sensorial se producía a los 102 días

Lifestyle Affects Amyloid Burden and Cognition Differently in Men and Women

OBJECTIVE Evidence on associations of lifestyle factors with Alzheimer's pathology and cognition are ambiguous, potentially because they rarely addressed inter-relationships of factors and sex effects. While considering these aspects, we examined the relationships of lifestyle factors with brain amyloid burden and cognition. METHODS We studied 178 cognitively normal individuals (women, 49%; 65.0 [7.6] years) and 54 individuals with mild cognitive impairment (women, 35%; 71.3 [8.3] years) enrolled in a prospective study of volunteers who completed $^{18}$ F-Flutemetamol amyloid positron emission tomography. Using structural equation modeling, we examined associations between latent constructs representing metabolic/vascular risk, physical activity, and cognitive activity with global amyloid burden and cognitive performance. Furthermore, we investigated the influence of sex in this model. RESULTS Overall, higher cognitive activity was associated with better cognitive performance and higher physical activity was associated with lower amyloid burden. The latter association was weakened to a nonsignificant level after excluding multivariate outliers. Examination of the moderating effect of sex in the model revealed an inverse association of metabolic/vascular risk with cognition in men, whereas in women metabolic/vascular risk trended toward increased amyloid burden. Furthermore, a significant inverse association between physical activity and amyloid burden was found only in men. Inheritance of an APOE4 allele was associated with higher amyloid burden only in women. INTERPRETATION Sex modifies effects of certain lifestyle-related factors on amyloid burden and cognition. Notably, our results suggest that the negative impact of metabolic/vascular risk influences the risk of cognitive decline and Alzheimer's disease through distinct paths in women and men. ANN NEUROL 2022;92:451-463

White matter hyperintensity patterns: associations with comorbidities, amyloid, and cognition

BACKGROUND White matter hyperintensities (WMHs) are often measured globally, but spatial patterns of WMHs could underlie different risk factors and neuropathological and clinical correlates. We investigated the spatial heterogeneity of WMHs and their association with comorbidities, Alzheimer's disease (AD) risk factors, and cognition. METHODS In this cross-sectional study, we studied 171 cognitively unimpaired (CU; median age: 65 years, range: 50 to 89) and 51 mildly cognitively impaired (MCI; median age: 72, range: 53 to 89) individuals with available amyloid (18F-flutementamol) PET and FLAIR-weighted images. Comorbidities were assessed using the Cumulative Illness Rating Scale (CIRS). Each participant's white matter was segmented into 38 parcels, and WMH volume was calculated in each parcel. Correlated principal component analysis was applied to the parceled WMH data to determine patterns of WMH covariation. Adjusted and unadjusted linear regression models were used to investigate associations of component scores with comorbidities and AD-related factors. Using multiple linear regression, we tested whether WMH component scores predicted cognitive performance. RESULTS Principal component analysis identified four WMH components that broadly describe FLAIR signal hyperintensities in posterior, periventricular, and deep white matter regions, as well as basal ganglia and thalamic structures. In CU individuals, hypertension was associated with all patterns except the periventricular component. MCI individuals showed more diverse associations. The posterior and deep components were associated with renal disorders, the periventricular component was associated with increased amyloid, and the subcortical gray matter structures was associated with sleep disorders, endocrine/metabolic disorders, and increased amyloid. In the combined sample (CU + MCI), the main effects of WMH components were not associated with cognition but predicted poorer episodic memory performance in the presence of increased amyloid. No interaction between hypertension and the number of comorbidities on component scores was observed. CONCLUSION Our study underscores the significance of understanding the regional distribution patterns of WMHs and the valuable insights that risk factors can offer regarding their underlying causes. Moreover, patterns of hyperintensities in periventricular regions and deep gray matter structures may have more pronounced cognitive implications, especially when amyloid pathology is also present

Levantamento de reconhecimento dos solos do Noroeste do Estado do Paraná: (informe preliminar).

A execucao do levantamento dos solos vem sendo realizada de maneira a atender as necessidades do estado e ao plano basico da EPFS, que visa ao inventario dos recursos potenciais dos solos do territorio nacional, consistindo na identificacao, classificacao, distribuicao e determinacao da area das diversas unidades de solos, de modo a proporcionar elementos basicos essenciais para planejamentos, principalmente os referntes a futuros trabalhos de levantamentos detalhados e ao estabelecimento racional de projetos de experimentacao e pesquisa, com possibilidades de aplicacao dos resultados em areas representativas de cada unidade que apresente expressao geografica importante, permitindo a extrapolacao dos resultados para solos semelhantes. O objetivo e o estudo dosdiferentes solos do Parana, atraves do reconhecimento da sua distribuicao geografica, delimitacao das areas por eles ocupadas e investigacao das suas caracteristicas morfologicas, fisicas e quimicas. O carater generalizado do mapeamento limita a precisao de detalhes cartograficos e nao pode ter por finalidade responder questoes de utilizacao de terras, problemas de fertilidade e produtividade em areas especificas. Procurou-se, tanto quanto possivel, elaborar a presente publicacao em forma simples, evitando ao maximo o excessivo emprego de termos tecnicos, a fim de poder atingir um maior numero de pessoas que dela possam fazer uso. Far-se-a, em seguida, a publicacao do levantamento do Noroeste e, finalmente, de todo o estado, abrangendo as suas varias regioes.bitstream/item/212067/1/EPFS-BT-14-1970.pdf; bitstream/item/125769/1/Levantamento-de-Reconhecimento-dos-Solos-do-Noroeste-do-Estado-do-Parana.pdfAcompanha 1 mapa, color. Escala 1:300.000

Cardio-Facio-Cutaneous Syndrome: Clinical Features, Diagnosis, and Management Guidelines

Cardio-facio-cutaneous syndrome (CFC) is one of the RASopathies that bears many clinical features in common with the other syndromes in this group, most notably Noonan syndrome and Costello syndrome. CFC is genetically heterogeneous and caused by gene mutations in the Ras/mitogen-activated protein kinase pathway. the major features of CFC include characteristic craniofacial dysmorphology, congenital heart disease, dermatologic abnormalities, growth retardation, and intellectual disability. It is essential that this condition be differentiated from other RASopathies, as a correct diagnosis is important for appropriate medical management and determining recurrence risk. Children and adults with CFC require multidisciplinary care from specialists, and the need for comprehensive management has been apparent to families and health care professionals caring for affected individuals. To address this need, CFC International, a nonprofit family support organization that provides a forum for information, support, and facilitation of research in basic medical and social issues affecting individuals with CFC, organized a consensus conference. Experts in multiple medical specialties provided clinical management guidelines for pediatricians and other care providers. These guidelines will assist in an accurate diagnosis of individuals with CFC, provide best practice recommendations, and facilitate long-term medical care.CFC International, Vestal, New YorkNational Institutes of HealthNational Institutes of Health (NIH)Univ Minnesota, Dept Pediat & Ophthalmol, Div Genet & Metab, Minneapolis, MN 55454 USAUniv Minnesota, Dept Pediat, Div Clin Behav Neuroscience, Minneapolis, MN 55454 USAChildrens Hosp & Clin Minnesota, St Paul, MN USATexas Childrens Hosp, Dept Mol & Human Genet, Houston, TX 77030 USABaylor Coll Med, Houston, TX 77030 USABenioff Childrens Hosp, Madison Clin Pediat Diabet, San Francisco, CA USAUniv Calif San Francisco, San Francisco, CA 94143 USAUniversidade Federal de São Paulo, Med Genet Ctr, São Paulo, BrazilCatholic Univ, A Gemelli Sch Med, Inst Med Genet, Rome, ItalyUniv Kentucky, Dept Pediat, Lexington, KY USAUniv Texas Hlth Sci Ctr San Antonio, Dept Orthoped, San Antonio, TX 78229 USABoston Childrens Hosp, Dept Cardiol, Boston, MA USABoston Childrens Hosp, Div Genet, Boston, MA USAHarvard Univ, Sch Med, Boston, MA USAEmory Univ, Sch Med, Dept Human Genet, Atlanta, GA USAEmory Univ, Sch Med, Dept Ophthalmol, Atlanta, GA 30322 USAUniv Calif San Francisco, Dept Neurol, San Francisco, CA USAYoungstown State Univ, Special Educ & Sch Psychol, Dept Counseling, Youngstown, OH 44555 USACFC Int, Vestal, NY USAUniv Calif Davis, UC Davis MIND Inst, Dept Pediat, Div Genom Med, Sacramento, CA 95817 USAUniversidade Federal de São Paulo, Med Genet Ctr, São Paulo, BrazilNational Institutes of Health: R01-AR062165Web of Scienc