The logistic principles in the education system

In article definitions of pedagogical logistics, the theoretical importance and her realization in an education system are considered. Theoretical concepts on implementation of consecutive transfer of knowledge in the conditions of educational logistics are describedВ статье рассматриваются дефиниции педагогической логистики, теоретическая значимость и реализация ее в системе образования. Описываются теоретические понятия по осуществлению последовательной передачи знаний в условиях образовательной логистик

Network educational programs

The article deals with topical issues of networking of educational organizations of the Russian Federation. An analysis of the theoretical justification of network interaction, which is used in the educational processВ статье рассмотрены актуальные вопросы сетевого взаимодействия образовательных организаций Российской Федерации. Произведен анализ теоретических обоснований сетевого взаимодействия, которое применяется в образовательном процесс

Principles of logistics and logistics system

Рассматриваются принципы логистической системы для организации рационального процесса движения образовательных услугThe article examines the principles of logistics system for the organization of rational process of the movement of educational service

Pedagogical logistics as a part of continuing education

The article analyzes opportunities for professional educational environment in the aspect of interaction between the school, College, University to improve the adequacy of the structure of knowledge transfer to studentsВ статье описываются возможности профессионального взаимодействия образовательной общеобразовательной школы, колледжа, вуза для повышения адекватности структуры передачи знаний обучающимс

Solar energy

This article is about the development of renewable sources in the form of solar energy. It features comprehensive discussions of many aspects of solar energy development in Russia and around the world. The purpose this article is to tell about advantages of solar energy

Lithium and magnesium isotopes fractionation by zone melting

The process of changing isotopic composition of the lithium and magnesium salts was studied by using the process of zone melting. It was founded in the paper that the process of separation of the lithium isotopes is more effective than for magnesium isotopes when the conditions of process were the same. The coefficients of isotopes separation were calculated and have the next value: [alpha]=1.006 for 26Mg isotope and [alpha]=1.0022 for {6}Li isotope

Protective Effect of Meso-Tetrakis-(3,5-di-tert-butyl-4-hydroxyphenyl)porphyrin on the In Vivo Impact of Trimethyltin Chloride on the Antioxidative Defense System

The in vivo effect of trimethyltin chloride (Me(3)SnCl), free base meso-tetrakis(3,5-di-tert-butyl-4-hydroxyphenyl)porphyrin (R′(4)PH(2)) and their equimolar mixture, on the enzymatic activity of catalase (CAT), superoxide dismutase (SOD), and on the total content of free sulfhydryl groups has been studied in rat liver and kidney. It was demonstrated that the simultaneous treatment of tested animals with the combination of Me(3)SnCl and R′(4)PH(2) reduced the toxic impact of Me(3)SnCl

Interaction between the Rev1 C-Terminal Domain and the PolD3 Subunit of Polζ Suggests a Mechanism of Polymerase Exchange upon Rev1/Polζ-Dependent Translesion Synthesis

Translesion synthesis (TLS) is a mutagenic branch of cellular DNA damage tolerance that enables bypass replication over DNA lesions carried out by specialized low-fidelity DNA polymerases. The replicative bypass of most types of DNA damage is performed in a two-step process of Rev1/Polζ-dependent TLS. In the first step, a Y-family TLS enzyme, typically Polη, Polι, or Polκ, inserts a nucleotide across a DNA lesion. In the second step, a four-subunit B-family DNA polymerase Polζ (Rev3/Rev7/PolD2/PolD3 complex) extends the distorted DNA primer-template. The coordinated action of error-prone TLS enzymes is regulated through their interactions with the two scaffold proteins, the sliding clamp PCNA and the TLS polymerase Rev1. Rev1 interactions with all other TLS enzymes are mediated by its C-terminal domain (Rev1-CT), which can simultaneously bind the Rev7 subunit of Polζ and Rev1-interacting regions (RIRs) from Polη, Polι, or Polκ. In this work, we identified a previously unknown RIR motif in the C-terminal part of PolD3 subunit of Polζ whose interaction with the Rev1-CT is among the tightest mediated by RIR motifs. Three-dimensional structure of the Rev1-CT/PolD3-RIR complex determined by NMR spectroscopy revealed a structural basis for the relatively high affinity of this interaction. The unexpected discovery of PolD3-RIR motif suggests a mechanism of “inserter” to “extender” DNA polymerase switch upon Rev1/Polζ-dependent TLS, in which the PolD3-RIR binding to the Rev1-CT (i) helps displace the “inserter” Polη, Polι, or Polκ from its complex with Rev1, and (ii) facilitates assembly of the four-subunit “extender” Polζ through simultaneous interaction of Rev1-CT with Rev7 and PolD3 subunits

Mediaaculture of Schoolchildren: Formation Technology in the Conditions of Children’s Health Camp

Статья посвящена исследованию уровней медиакультуры школьников и повышения их с помощью медиатехнологии в рамках детского оздоровительного лагеря. На материалах социально-педагогического эксперимента показано, что создание медиакружка в социально-культурном учреждении является эффективной технологией повышения уровней медиакультуры и медиаграмотности школьников, способствующей развитию у подрастающего поколения критичного, индивидуального, творческого мышления.The article is devoted to the study of the levels of media culture of schoolchildren and their increase with the help of media technology in the framework of a children’s recreation camp. Based on the materials of the socio-pedagogical experiment, it is shown that the creation of a media circle in a socio-cultural institution is an effective technology for increasing the levels of media culture and media literacy of schoolchildren. The active involvement of students aged 11–15 in the work of such a circle contributes to the development of a younger generation of critical, individual, creative thinking

Acute phlegmonous appendicitis in rare variant of appendix diverticulum (case report)

Background. Appendicitis-like diverticulitis is considered a rare disease and is usually the subject of clinical reports. Clinical manifestations of this pathology is similar to those of appendicitis, which is why a preoperative diagnosis is made quite rarely. When carrying out the study, we considered a clinical case of acute phlegmonous appendicitis with a rare variant of the appendix wall diverticulum.Material and methods. To assess clinical cases, a retrospective analysis of medical documentation (medical records of patients with diverticulitis in particular) was used. The assessment of clinical symptoms was accompanied by using general clinical, histological and microbiological methods.Results. Patient I., 62 years old, was diagnosed with acute appendicitis. An urgent appendectomy was carried out, during which the vermiform process was removed. It was located retrocecally, in the adhesive process and loose infiltrate. The length of the process is 7–8 cm, its diameter is 1–1,5 cm. 6 diverticula up to 0,7 cm in size are visible. When the process is cut, the pyoid contents protrudes from its lumen. In addition, the appendix removed during appendectomy was sent for pathological study. A standard histopathological study was carried out with the step-like sectioning and hematoxylin and eosin staining.Conclusion. From the results of a pathological study, it was found that the layers of the vermiform process wall with diverticula are diffusely infiltrated by polymorphonuclear leukocytes. The mucous membrane is anesthetized and had ulcerative defects. The patient was diagnosed with phlegmonous appendicitis, periappendicitis, diverticulitis.Vermiform process diverticulitis is not a common pathology, however a timely diagnosis can cause quite severe complications