Synthesis and biological evaluation of platinum complexes of highly functionalized aroylaminocarbo-N-thioyl prolinate containing tetrahydropyrrolo[3,4-c]pyrrole-1,3(2H,3aH)-dione moieties

Platinum complexes, derived from two families of bidentate funcionalized aroylaminocarbo-N-thyoyl prolinates, are prepared using mild conditions from prolinates, which are available via 1,3-dipolar cycloadditions. The resulting four coordinated neutral square-planar platinum(II) complexes are very stable and are fully characterized. Their structures are determined by spectroscopic and analytical methods and one of them by single crystal X-ray diffraction analysis. In this pattern, the platinum exhibits distorted square planar geometry, with cis-bond angles ranging from 89.42(2) and 94.37(6)° and trans-bond angles of 176.19(6) and 177.08(6)°, respectively. Anti(myco)bacterial and antifungal studies of all these new compounds are carried out under standardized protocols.This work is a part of Samet Belveren's ongoing PhD thesis granted by Mersin University (Project no. BAP-SBE TEB(SB) 2017-2-TP3-2564). We gratefully acknowledge financial support from Mersin University and the Spanish Ministerio de Economía y Competitividad (MINECO) (projects CTQ2013-43446-P and CTQ2014-51912-REDC), the Spanish Ministerio de Economía, Industria y Competitividad, Agencia Estatal de Investigación (AEI) and Fondo Europeo de Desarrollo Regional (FEDER, EU) (projects CTQ2016-76782-P and CTQ2016-81797-REDC), the Generalitat Valenciana (PROMETEOII/2014/017), University of Alicante and Mersin University (Project. MEU-2017-COL-01007-M150D)

New constraints on micro-seismicity and stress state in the western part of the North Anatolian Fault Zone : Observations from a dense seismic array

Major funding was provided by the UK Natural Environment Research Council (NERC) under grant NE/I028017/1 and partially supported by Boğaziçi University Research Fund (BAP) under grant 6922. We would like to thank all the project members from the University of Leeds, Boğaziçi University, Kandilli Observatory, Aberdeen University and Sakarya University. I would also like to thank Prof. Ali Pinar and Dr. Kıvanç Kekovalı for their valuable comments. Some of the figures were generated by GMT software (Wessel and Smith, 1995).Peer reviewedPostprin

Middle interhemispheric holoprosencephaly with subdural hematoma

Background: A 4-month-old boy with prenatal sonography findings consistent with corpus callosum agenesis and ventriculomegaly presented. Patient was born at 37-weeks from 18-yearold woman, gravida 1 para 1. There was no history of teratogen exposure in utero such as radiation, alcohol, drug or postnatal trauma. There was no family history of brain malformations nor chromosomal abnormalities. Clinically no facial abnormality was observed. The mother had gestational diabetes during pregnancy. The baby was delivered by means of cesarean section because of severe eclampsia at 37 weeks. Postnatal routine physical examination of patient was normal

Coronary arterial anomalies in a large group of patients undergoing coronary angiography in southeast Turkey

Background: The prevalence of coronary artery anomalies (CAA) are reportedbetween 0.6–1.3% in the literature. CAA are usually asymptomatic incidental findings, but they may deteriorate coronary circulation, cause symptoms andlead to sudden cardiac death; especially in young athletes. Since interventionalprocedures are increasing rapidly for treatment of coronary artery disease (CAD) inthe modern era, comprehensive understanding of CAA is becoming progressively critical element in dealing with CAD.Materials and methods: We reviewed the database of the Cardiac Catheterisation Laboratory of Sani Konukoglu University Hospital in Gaziantep, Turkey. All patientswho were subjected to coronary angiography from 1998 to 2006 were included.Results: Among 53,655 coronary angiographies performed, CAA were foundin 653 patients (incidence of 1.21%); 590 (90.3%) patients had anomalies oforigin and distribution and 63 (11.7%) had coronary fistulae. Separate origins ofleft anterior descending (LAD) and left circumflex (LCX) coronary artery from theleft sinus of Valsalva was the most common anomaly (64.1%). Coronary arteriesbranching from anomalous aortic origin was the second most common anomaly(16.5%). Right coronary artery (RCA) originating from left sinus of Valsalva or leftmain coronary artery (LMCA) was observed in 55 (8.4%) patients, LCX arising fromRCA or right sinus of Valsalva (RSV) was seen in 52 (7.9%) patients and LMCA orLAD originating from RSV was seen in 14 (0.2%) patients. There were 16 (2.45%) patients with single coronary artery and 1 (0.15%) patient with LMCA originating from pulmonary artery.Conclusions: The incidence and the pattern of CAA in our patient population were similar with previous studies. Angiographic recognition of these vessels is importantbecause of their clinical significance and importance in patients undergoing coronary angioplasty or cardiac surgery

Nodular regenerative hyperplasia of the liver and portal thrombosis

Background: A 35-year-old female presented with upper gastrointestinal tract bleeding. Fifteen years ago, the diagnosis of esophageal varices caused by idiopathic portal venous thrombus was made. Follow-up examinations revealed mild elevation of bilirubin levels and normal alphafetoprotein level on blood tests. Splenectomy had been performed 6 years previously due to portal hypertension caused by portal venous thrombus

Titanium based bone implants production using laser powder bed fusion technology

Additive manufacturing (AM) enables fully dense biomimetic implants in the designed geometries from preferred materials such as titanium and its alloys. Titanium aluminum vanadium (Ti6Al4V) is one of the pioneer metal alloys for bone implant applications, however, the reasons for eliminating the toxic effects of Ti6Al4V and maintaining adequate mechanical strength have increased the potential of commercially pure titanium (cp-Ti) to be used in bone implants. This literature review aims to evaluate the production of cp-Ti and Ti6Al4V biomedical implants with laser powder bed fusion (L-PBF) technology, which has a very high level of technological matureness and industrialization level. The optimization of L-PBF manufacturing parameters and post-processing techniques affect the obtained microstructure leading to various mechanical, corrosion and biological behaviors of the manufactured titanium. All of the features are considered in the light of specifications and needs of bone implant applications. The most critical disadvantages of the L-PBF technology, such as residual stresses and leading deformations are introduced and the potential solutions are discussed. Moreover, the manufacturability of porous bone implants that causes benefit and harm in L-PBF applications are assessed.Peer ReviewedObjectius de Desenvolupament Sostenible::3 - Salut i BenestarPostprint (published version

LWIR all-atomic layer deposition ZnO bilayer microbolometer for thermal imaging

We propose an all-ZnO bilayer microbolometer, operating in the long-wave infrared regime that can be implemented by consecutive atomic layer deposition growth steps. Bilayer design of the bolometer provides very high absorption coefficients compared to the same thickness of a single ZnO layer. High absorptivity of the bilayer structure enables higher performance (lower noise equivalent temperature difference and time constant values) compared to single-layer structure. We observe these results computationally by conducting both optical and thermal simulations. © 2017 Society of Photo-Optical Instrumentation Engineers (SPIE)

Demographic Features of Turkish Literature Audiences and Applied Analysis of the Factors Affecting Their Reading Preferences,

The purpose of this study is to determine factors affecting reading preferences in parallel with the demographic features of Turkish literature audiences. The study lasted approximately for 7 months. (N=650) individuals attended the study in total. The universe of the study is Turkey while the sample of the study is composed of 8 different provinces. These provinces are İstanbul, Ankara, İzmir, Bursa, Kocaeli, Sakarya, Trabzon and Gaziantep. A questionnaire form whose reliability and validity had been ensured before and which was composed of 5 point Likert scale was used in the study. The questionnaire form was reformed in accordance with the topic of the study, it was subjected to validity and reliability test and it was carried into main practice through taking views of experts. Data acquired from the results of main practice was analyzed by using SPSS 18.0 packet program and the value of 0.924 was acquired as Cronbach’s Alpha co-efficient. This value indicates that the measuring tool used in this study is quite reliable. The questionnaire is composed of two sections. In the first section, there are questions with regard to determine demographic features of the participants while in the second section, there are scaled questions composed of 120 items. 0.05 of significance level was taken into account among variables in terms of relations and differences. Methods such as different statistics anova, factor and hypothesis tests were applied in the analysis. Moreover, 4 different literary works were mentioned in the study so as to determine attitudes and behaviors of the participants towards literary works. Opinions of the participants were demanded about novels such as İntibah (Rebirth), Araba Sevdası (Ambition for Car), Mai ve Siyah (Blue and Black) and Çalıkuşu (The Wren). At the end of the study, it was found out that the participants followed academic publications more frequently, the use of computer and internet had an effect on reading e-book and up-to-date books were read more than those books written in a foreign or ancient language (Ottoman Turkish). Furthermore, it was determined that education and age variables of the participants had an effect on reading habits while gender, age and education variables had an effect in some reading factors