59 research outputs found
Academic Dishonesty and Testing: How Student Beliefs and Test Settings Impact Decisions to Cheat
Research shows that academic dishonesty in post-secondary education runs particularly high among students in the specific disciplines of engineering, business, and nursing. The authors were interested in how student attitudes towards specific environments for testing might contribute to the prevalence or likelihood of cheating on tests and exams. It was hypothesized that while there would be no difference in their beliefs or attitudes regarding the acceptability of cheating behaviors in unproctored versus proctored settings, students would be more likely to engage in cheating behavior in an unproctored setting. Technology continues to transform the world around us at a rapid pace, allowing faculty to incorporate more technology into the classroom and to educate more students remotely via hybrid and online classes. While these opportunities have their benefits, they also present new challenges. The opportunity for cheating on tests increases, especially when exams are delivered in unproctored environments. An instrument was created to investigate the attitudes and behaviors of first- and second-year undergraduate engineering students while taking tests in both proctored and unproctored environments. In all, 734 students were surveyed from four different institutions of higher education. Students provided both qualitative and quantitative responses to questions related to their beliefs and attitudes toward cheating in today’s socially shareable society. Results indicated that both students’ attitudes and behaviors vary as a result of tests being delivered in a proctored versus unproctored environment
High-throughput Quantum Chemistry: Empowering the Search for Molecular Candidates behind Unknown Spectral Signatures in Exoplanetary Atmospheres
The identification of molecules in exoplanetary atmospheres is only possible
thanks to the availability of high-resolution molecular spectroscopic data.
However, due to its intensive and time-consuming generation process, at
present, only on order 100 molecules have high-resolution spectroscopic data
available, limiting new molecular detections.
Using routine quantum chemistry calculations (i.e., scaled harmonic frequency
calculations using the B97-1/def2-TZVPD model chemistry with median errors of
10cm-1), here we present a complementary high-throughput approach to rapidly
generate approximate vibrational spectral data for 2743 molecules made from the
biologically most important elements C, H, N, O, P and S. Though these data are
not accurate enough to enable definitive molecular detections and does not seek
to replace the need for high-resolution data, it has powerful applications in
identifying potential molecular candidates responsible for unknown spectral
features. We explore this application for the 4.1 micron (2439cm-1) feature in
the atmospheric spectrum of WASP-39b, listing potential alternative molecular
species responsible for this spectral line, together with SO2. Further
applications of this big data compilation also include identifying molecules
with strong absorption features that are likely detectable at quite low
abundances, and training set for machine learning predictions of vibrational
frequencies.
Characterising exoplanetary atmospheres through molecular spectroscopy is
essential to understand the planet's physico-chemical processes and likelihood
of hosting life. Our rapidly generated quantum chemistry big data set will play
a crucial role in supporting this understanding by giving directions into
possible initial identifications of the more unusual molecules to emerge
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Microflow of fluorescently labelled red blood cells in tumours expressing single isoforms of VEGF and their response to VEGF-R tyrosine kinase inhibition
This paper was presented at the 2nd Micro and Nano Flows Conference (MNF2009), which was held at Brunel University, West London, UK. The conference was organised by Brunel University and supported by the Institution of Mechanical Engineers, IPEM, the Italian Union of Thermofluid dynamics, the Process Intensification Network, HEXAG - the Heat Exchange Action Group and the Institute of Mathematics and its Applications.In this work we studied the functional differences between the microcirculation of murine tumours that only express single isoforms of vascular endothelial growth factor-A (VEGF), VEGF120 and VEGF188, and the effect of VEGF receptor tyrosine kinase (VEGF-R TK) inhibition on their functional response to the vascular disrupting agent, combretastatin A-4 phosphate (CA-4-P). We used measurement of fluorescentlylabelled
red blood cell (RBC) velocities in tumour microvessels to study this functional response. RBC velocity for control VEGF120-expressing tumours was over 50% slower than for control VEGF188-expressing tumours, which may be due to the immature and haemorrhagic vasculature of the VEGF120
tumour. After chronic treatment with a VEGF-R tyrosine kinase inhibitor, SU5416, RBC velocities in VEGF120 tumours were significantly increased compared to control VEGF120 tumours, and similar to velocities in both VEGF188 treatment groups. Control and SU5416 treated VEGF188 tumours were not
different from each other. Treatment of VEGF120 tumours with SU5416 reduced their vascular response to CA-4-P to a similar level to the VEGF188 tumours. Differential expression of VEGF isoforms not only affected vascular function in untreated tumours but also impacted on response to a vascular disrupting drug, CA-4-P, alone and in combination with an anti-angiogenic approach involving VEGF-R TK inhibition.
Analysis of RBC velocities is a useful tool in measuring functional responses to vascular targeted treatments.This study is funded by the Cancer Research UK
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Microflow of fluorescently labelled red blood cells in tumours expressing single isoforms of VEGF and their response to VEGF-R tyrosine kinase inhibition
In this work we studied the functional differences between the microcirculation of murine tumours that only express single isoforms of vascular endothelial growth factor-A (VEGF), VEGF120 and VEGF188, and the effect of VEGF receptor tyrosine kinase (VEGF-R TK) inhibition on their functional response to the vascular disrupting agent, combretastatin A-4 phosphate (CA-4-P). We used measurement of fluorescently- labelled red blood cell (RBC) velocities in tumour microvessels to study this functional response. RBC velocity for control VEGF120-expressing tumours was over 50% slower than for control VEGF188- expressing tumours, which may be due to the immature and haemorrhagic vasculature of the VEGF120 tumour. After chronic treatment with a VEGF-R tyrosine kinase inhibitor, SU5416, RBC velocities in VEGF120 tumours were significantly increased compared to control VEGF120 tumours, and similar to velocities in both VEGF188 treatment groups. Control and SU5416 treated VEGF188 tumours were not different from each other. Treatment of VEGF120 tumours with SU5416 reduced their vascular response to CA-4-P to a similar level to the VEGF188 tumours. Differential expression of VEGF isoforms not only affected vascular function in untreated tumours but also impacted on response to a vascular disrupting drug, CA-4-P, alone and in combination with an anti-angiogenic approach involving VEGF-R TK inhibition. Analysis of RBC velocities is a useful tool in measuring functional responses to vascular targeted treatments
Chaotic dynamics of falling disks
The study of the motion of flat bodies falling in a viscous medium dates back at least to Newton(1) and Maxwell(2), and is relevant to problems in meteorology(3), sedimentology(4), aerospace engineering(1) and chemical engineering(5-8). More recent theoretical studies(9-12) have emphasized the role played by deterministic chaos, although many experimental studies(1,5-8,13,14) were performed before the development of such ideas. Here we report experimental observations of the dynamics of disks falling in water/glycerol mixtures. We find four distinct types of motion, which are mapped out in a 'phase diagram'. The apparently complex behaviour can be reduced to a series of one-dimensional maps, which display a discontinuity at the crossover from periodic to chaotic motion. This discontinuity leads to an unusual intermittency transition(15), not previously observed experimentally, between the two behaviours.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/62793/1/388252a0.pd
Radio Astronomy
Contains reports on three research project.National Science Foundation (Grant GP-21348A#2)California Institute of Technology (Contract 952568)National Aeronautics and Space Administration (Grant NGR 22-009-421)U. S. Air Force - Electronic Systems Division (Contract F19628-73-C-0196
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The underlying causes of military outsourcing in the USA and UK: bridging the persistent gap between ends, ways and means since the beginning of the Cold War
This article reappraises the two most-studied country cases of military outsourcing: the USA and the UK. It argues that the contemporary wave of military contracting stretches back to the beginning of the cold war and not only to the demobilisation of armies in the 1990s or the neoliberal reforms introduced since the 1980s. It traces the political, technological and ideational developments that laid the groundwork for these reforms and practices since the early cold war and account for its endurance today. Importantly, it argues that a persistent gap between strategic objectives and resources, i.e. the challenge to reconcile ends and means, is an underlying driver of military contracting in both countries. Contemporary contracting is thus most closely tied to military support functions in support of wider foreign and defence political objectives. Security services in either state may not have been outsourced so swiftly, if at all, without decades of experience in outsourcing military logistics functions and the resultant vehicles, processes and familiarities with public-private partnerships. The article thus provides a wider and deeper understanding of the drivers of contractualisation, thereby improving our understanding of both its historical trajectory and the determinants of its present and potential futures
An investigation of the behavior of a classifying hydrocyclone with pseudoplastic fluids
Blood pressure-lowering effects of nifedipine/candesartan combinations in high-risk individuals: Subgroup analysis of the DISTINCT randomised trial
The DISTINCT study (reDefining Intervention with Studies Testing Innovative Nifedipine GITS - Candesartan Therapy) investigated the efficacy and safety of nifedipine GITS/candesartan cilexetil combinations vs respective monotherapies and placebo in patients with hypertension. This descriptive sub-analysis examined blood pressure (BP)-lowering effects in high-risk participants, including those with renal impairment (estimated glomerular filtration rate<90 ml min-1, n=422), type 2 diabetes mellitus (n=202), hypercholesterolaemia (n=206) and cardiovascular (CV) risk factors (n=971), as well as the impact of gender, age and body mass index (BMI). Participants with grade I/II hypertension were randomised to treatment with nifedipine GITS (N) 20, 30, 60 mg and/or candesartan cilexetil (C) 4, 8, 16, 32 mg or placebo for 8 weeks. Mean systolic BP and diastolic BP reductions after treatment in high-risk participants were greater, overall, with N/C combinations vs respective monotherapies or placebo, with indicators of a dose-response effect. Highest rates of BP control (ESH/ESC 2013 guideline criteria) were also achieved with highest doses of N/C combinations in each high-risk subgroup. The benefits of combination therapy vs monotherapy were additionally observed in patient subgroups categorised by gender, age or BMI. All high-risk participants reported fewer vasodilatory adverse events in the pooled N/C combination therapy than the N monotherapy group. In conclusion, consistent with the DISTINCT main study outcomes, high-risk participants showed greater reductions in BP and higher control rates with N/C combinations compared with respective monotherapies and lesser vasodilatory side-effects compared with N monotherapy
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