Evidence for particle-hole excitations in the triaxial strongly-deformed well of ^{163}Tm

Two interacting, strongly-deformed triaxial (TSD) bands have been identified in the Z = 69 nucleus ^{163}Tm. This is the first time that interacting TSD bands have been observed in an element other than the Z = 71 Lu nuclei, where wobbling bands have been previously identified. The observed TSD bands in ^{163}Tm appear to be associated with particle-hole excitations, rather than wobbling. Tilted-Axis Cranking (TAC) calculations reproduce all experimental observables of these bands reasonably well and also provide an explanation for the presence of wobbling bands in the Lu nuclei, and their absence in the Tm isotopes.Comment: 13 pages, 7 figure

High-spin structure and Band Termination in 103^{103}Cd

Excited states of the neutron deficient $^{103}$Cd nucleus have been investigated via the $^{72}$Ge($^{35}$Cl, p3n) reaction at beam energy of 135 MeV by use of in-beam spectroscopic methods. Gamma rays depopulating the excited states were detected using the Gammasphere spectrometer with high-fold $\gamma$-ray coincidences. A quadrupole $\gamma$-ray coincidence analysis ($\gamma^{4}$) has been used to extend the known level scheme. The positive parity levels have been established up to $J = 35/2\hbar$ and $E_{x} = 7.071$ MeV. In addition to the observation of highly-fragmented level scheme belonging to the positive-parity sequences at E$_{x}\sim$ 5 MeV, the termination of a negative-parity sequence connected by $E2$ transitions has been established at $J = 47/2 \hbar$ and $E_{x} = 11.877$ MeV. The experimental results corresponding to both the positive- and negative-parity sequences have been theoretically interpreted in the framework of the core particle coupling model. Evidence is presented for a shape change from collective prolate to non-collective oblate above the $J^{\pi} = 39/2^{-}$ (8011 keV) level and for a smooth termination of the negative-parity band.Comment: 19 pages, 8 figures. Submitted to Phys. Rev.

High-spin structure and Band Termination in 103^{103}Cd

Excited states of the neutron deficient $^{103}$Cd nucleus have been investigated via the $^{72}$Ge($^{35}$Cl, p3n) reaction at beam energy of 135 MeV by use of in-beam spectroscopic methods. Gamma rays depopulating the excited states were detected using the Gammasphere spectrometer with high-fold $\gamma$-ray coincidences. A quadrupole $\gamma$-ray coincidence analysis ($\gamma^{4}$) has been used to extend the known level scheme. The positive parity levels have been established up to $J = 35/2\hbar$ and $E_{x} = 7.071$ MeV. In addition to the observation of highly-fragmented level scheme belonging to the positive-parity sequences at E$_{x}\sim$ 5 MeV, the termination of a negative-parity sequence connected by $E2$ transitions has been established at $J = 47/2 \hbar$ and $E_{x} = 11.877$ MeV. The experimental results corresponding to both the positive- and negative-parity sequences have been theoretically interpreted in the framework of the core particle coupling model. Evidence is presented for a shape change from collective prolate to non-collective oblate above the $J^{\pi} = 39/2^{-}$ (8011 keV) level and for a smooth termination of the negative-parity band.Comment: 19 pages, 8 figures. Submitted to Phys. Rev.

A Composite Chiral Pair of Rotational Bands in the odd-A Nucleus 135Nd

High-spin states in 135Nd were populated with the 110Pd(30Si,5n)135Nd reaction at a 30Si bombarding energy of 133 MeV. Two Delta(I)=1 bands with close excitation energies and the same parity were observed. These bands are directly linked by Delta(I)=1 and Delta(I)=2 transitions. The chiral nature of these two bands is confirmed by comparison with three-dimensional tilted axis cranking calculations. This is the first observation of a three-quasiparticle chiral structure and established the primarily geometric nature of this phenomenon.Comment: 10 pages, 5 figures (1 in color), 1 table, submitted to Physics Review Letters, written in REVTEX4 forma

Lifetime measurements of Triaxial Strongly Deformed bands in 163^{163}Tm

With the Doppler Shift Attenuation Method, quadrupole transition moments, $Q_t$, were determined for the two recently proposed Triaxial Strongly Deformed (TSD) bands in $^{163}$Tm. The measured $Q_t$ moments indicate that the deformation of these bands is larger than that of the yrast, signature partners. However, the measured values are smaller than those predicted by theory. This observation appears to be valid for TSD bands in several nuclei of the regionComment: 8 pages, 5 figures. Submitted to Physical Review

An Intrinsically Disordered Region of the Acetyltransferase p300 with Similarity to Prion-Like Domains Plays a Role in Aggregation

Several human diseases including neurodegenerative disorders and cancer are associated with abnormal accumulation and aggregation of misfolded proteins. Proteins with high tendency to aggregate include the p53 gene product, TAU and alpha synuclein. The potential toxicity of aberrantly folded proteins is limited via their transport into intracellular sub-compartments, the aggresomes, where misfolded proteins are stored or cleared via autophagy. We have identified a region of the acetyltransferase p300 that is highly disordered and displays similarities with prion-like domains. We show that this region is encoded as an alternative spliced variant independently of the acetyltransferase domain, and provides an interaction interface for various misfolded proteins, promoting their aggregation. p300 enhances aggregation of TAU and of p53 and is a component of cellular aggregates in both tissue culture cells and in alpha-synuclein positive Lewy bodies of patients affected by Parkinson disease. Down-regulation of p300 impairs aggresome formation and enhances cytotoxicity induced by misfolded protein stress. These data unravel a novel activity of p300, offer new insights into the function of disordered domains and implicate p300 in pathological aggregation that occurs in neurodegeneration and cancer

Complex ferromagnetic state and magnetocaloric effect in single crystalline Nd_{0.7}Sr_{0.3}MnO_{3}

The magnetocaloric effect in single crystalline Nd_{0.7}Sr_{0.3}MnO_{3} is investigated by measuring the field-induced adiabatic change in temperature which reveals a single negative peak around 130 K well below the Curie temperature (T_C=203 K). In order to understand this unusual magnetocaloric effect, we invoke the reported {55}^Mn spin-echo nuclear magnetic resonance, electron magnetic resonance and polarized Raman scattering measurements on Nd_{0.7}Sr_{0.3}MnO_{3}. We show that this effect is a manifestation of a competition between the double exchange mechanism and correlations arising from coupled spin and lattice degrees of freedom which results in a complex ferromagnetic state. The critical behavior of Nd_{0.7}Sr_{0.3}MnO_{3} near Curie temperature is investigated to study the influence of the coupled degrees of freedom. We find a complicated behavior at low fields in which the order of the transition could not be fixed and a second-order-like behavior at high fields.Comment: Accepted for publication in Phys. Rev.

Understanding the Dynamical State of Globular Clusters: Core-Collapsed vs Non Core-Collapsed

We study the dynamical evolution of globular clusters using our H\'enon-type Monte Carlo code for stellar dynamics including all relevant physics such as two-body relaxation, single and binary stellar evolution, Galactic tidal stripping, and strong interactions such as physical collisions and binary mediated scattering. We compute a large database of several hundred models starting from broad ranges of initial conditions guided by observations of young and massive star clusters. We show that these initial conditions very naturally lead to present day clusters with properties including the central density, core radius, half-light radius, half-mass relaxation time, and cluster mass, that match well with those of the old Galactic globular clusters. In particular, we can naturally reproduce the bimodal distribution in observed core radii separating the "core-collapsed" vs the "non core-collapsed" clusters. We see that the core-collapsed clusters are those that have reached or are about to reach the equilibrium "binary burning" phase. The non core-collapsed clusters are still undergoing gravo-thermal contraction.Comment: 42 pages, 12 figures, 1 table, submitted to MNRA

miR-139-5p is a regulator of metastatic pathways in breast cancer

Metastasis is a complex, multistep process involved in the progression of cancer from a localized primary tissue to distant sites, often characteristic of the more aggressive forms of this disease. Despite being studied in great detail in recent years, the mechanisms that govern this process remain poorly understood. In this study, we identify a novel role for miR-139-5p in the inhibition of breast cancer progression. We highlight its clinical relevance by reviewing miR-139-5p expression across a wide variety of breast cancer subtypes using in-house generated and online data sets to show that it is most frequently lost in invasive tumors. A biotin pull-down approach was then used to identify the mRNA targets of miR-139-5p in the breast cancer cell line MCF7. Functional enrichment analysis of the pulled-down targets showed significant enrichment of genes in pathways previously implicated in breast cancer metastasis (P < 0.05). Further bioinformatic analysis revealed a predicted disruption to the TGFβ, Wnt, Rho, and MAPK/PI3K signaling cascades, implying a potential role for miR-139-5p in regulating the ability of cells to invade and migrate. To corroborate this finding, using the MDA-MB-231 breast cancer cell line, we show that overexpression of miR-139-5p results in suppression of these cellular phenotypes. Furthermore, we validate the interaction between miR-139-5p and predicted targets involved in these pathways. Collectively, these results suggest a significant functional role for miR-139-5p in breast cancer cell motility and invasion and its potential to be used as a prognostic marker for the aggressive forms of breast cancer

Принципы стратегического планирования деятельности нефтяной компании Кот Д’Ивуар

В процессе исследования проводился: анализ современных мировых тенденций развития нефтегазовой промышленности; были проанализированы основные принципы и методы стратегического планирования развития компаний российского нефтегазового комплекса; на примере конкретных компаний; проведен сравнительный анализ методов и принципов стратегического планирования НГК России и нефтегазового сектора Кот-д’Ивуара.In the process of the study, the analysis of the current global trends in the development of the oil and gas industry was carried out; the main principles and methods of strategic planning for the development of companies of the Russian oil and gas complex were analyzed; on the example of specific companies; a comparative analysis of the methods and principles of strategic planning of the Russian oil and gas industry and the oil and gas sector in Cote d'Ivoire