Pectus excavatum asociado a ectopia cordis en un neonato bovino

Se presenta el caso de un neonato bovino de 4 horas de nacido con Pectus excavatum asociada a Ectopia cordis . Se destaca la importancia del caso debido a la rareza de presentación de las dos patologías conjuntas en animales, aunada a la ausencia de no reporte del Pectus exacavatum en Bovinos

Pectus excavatum asociado a ectopia cordis en un neonato bovino

Pectus excavatum associated to Cordis ectopia was diagnosticed in a 4 hours old neonatal cay. This case has a big concerned because of the presentation of two pathologies in animals is uncommon, and Pectus excavatum had never been reported before in bovine.Se presenta el caso de un neonato bovino de 4 horas de nacido con Pectus excavatum asociada a Ectopia cordis. Se destaca la importancia del caso debido a la rareza de presentación de las dos patologías conjuntas en animales, aunada a la ausencia de no reporte del Pectus exacavatum en Bovinos

Influence of Lipid Saturation Grade and Headgroup Charge: A Refined Lung Surfactant Adsorption Model

Rapid adsorption of surfactant material to the air/liquid interface of the lung is essential for maintaining normal lung function. The detailed mechanism of this process, however, remains unclear. In this study, we elucidate the influence of lipid saturation grade and headgroup charge of surface layer lipids on surfactant protein (SP)-induced vesicle insertion into monolayers spread at the air/water interface of a film balance. We used dipalmitoylphosphatidlycholine (DPPC),1,2-dipalmitoyl-sn-glycero-3-phosphoglycerol (DPPG), 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC), and 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol (POPG) as monolayer lipids doped with either hydrophobic surfactant-specific protein SP-B or SP-C (0.2 and 0.4 mol %, respectively). Vesicles consisting of DPPC/DPPG (4:1, mol ratio) were injected into a stirred subphase to quantify adsorption kinetics. Based on kinetic film balance and fluorescence measurements, a refined model describing distinct steps of vesicle adsorption to surfactant monolayers is presented. First, in a protein-independent step, lipids from vesicles bridged to the interfacial film by Ca2+ ions are inserted into defects of a disordered monolayer at low surface pressures. Second, in a SP-facilitated step, active material insertion involving an SP-B- or SP-C-induced flip-flop of lipids occurs at higher surface pressures. Negatively charged lipids obviously influence the threshold pressures at which this second protein-mediated adsorption mechanism takes place