Global Health Governance and the Commercial Sector: A Documentary Analysis of Tobacco Company Strategies to Influence the WHO Framework Convention on Tobacco Control

Heide Weishaar and colleagues did an analysis of internal tobacco industry documents together with other data and describe the industry's strategic response to the proposed World Health Organization Framework Convention on Tobacco Control

Wireless networked control systems with QoS-based sampling

The design of control, estimation or diagnosis algorithms most often assumes that all available process variables represent the system state at the same instant of time. However, this is never true in current network systems, because of the unknown deterministic or stochastic transmission delays introduced by the communication network. During the diagnosing stage, this will often generate false alarms. Under nominal operation, the different transmission delays associated with the variables that appear in the computation form produce discrepancies of the residuals from zero. A technique aiming at the minimisation of the resulting false alarms rate, that is based on the explicit modelling of communication delays and on their best-case estimation is propose

CBFA2T3::GLIS2‐positive acute leukemia with RAM and mixed T/megakaryocytic phenotype

Abstract Herein, we present a rare case of acute myeloid leukemia (AML) with CBFA2T3‐rearrangement and the expression of megakaryocytic and lymphoid markers, highlighting the need for a high suspicion index in differential diagnosis and applying adequate workup to avoid misdiagnosing this entity. CBFA2T3::GLIS2‐positive AML is primarily found in infants with non‐down syndrome acute megakaryoblastic leukemia (non‐DSAMKL). Flow cytometry immunophenotyping plays an important role in recognizing the unique immunophenotype of bright CD56 expression with dim/negative expression of HLA‐DR, CD38, and CD45 termed the RAM immunophenotype in this entity. Still, CBFA2T3::GLIS2‐positive acute leukemia with T/megakaryocytic markers could be misdiagnosed as T‐lymphoblastic leukemia/lymphoma, early T‐cell precursor acute lymphoblastic leukemia/lymphoma, NK lymphoblastic leukemia, AML with minimal differentiation, or AML with myelodysplasia‐related changes

Beyond Community Engagement: Transforming dialogues in art, education and the cultural sphere

This book reconsiders fundamental questions about relationships between community engagement, art and education within cultural spheres. Transdisciplinary chapters bring together researchers as “insider-practitioners” to challenge assumptions and offer new insights about practice, engagement and possibilities for transformation. The chapters reflect both localised projects and international perspectives on ecologies of practice as a key marker of the mobility of ideas as well as social mobility. Addressing socially engaged, informal pedagogy re-examines the aesthetic possibilities of social capital in the public domain. Re-considering contributions of education and research through transfer of knowledge and expertise across small social collectives, partnerships and larger institutional agencies is a growing practice. Examining equity and types of participation alongside issues of local and global significance is emergent in new, pop-up and continuing communities. Gauging social impact through case studies is an important project within the tertiary sector to ensure that critically reflexive visual research methodologies gain currency within contemporary neo-liberal funding and educational agendas. In the current milieux we ask, is all engagement transformative, educative, sustainable and linked to democratizing principles that address civic agendas? Re-imagining sites/situations of learning, culture and place as “practice encounters” utilises practices relevant for educators and practitioners. Applications of ecology, practice architectures and site ontologies inform broader social challenges. Conceiving arts-based research as a network, prioritises transitions and becomings to re-conceptualise the significance of relationships within local/global connectivity. Linking professional networks and agencies to adaptive communities, creates an expanded field of real world creative partnerships to enable changing pedagogies

Key points for the development of antioxidant cocktails to prevent cellular stress and damage caused by reactive oxygen species (ROS) during manned space missions

Exposure to microgravity and ionizing radiation during spaceflight missions causes excessive reactive oxygen species (ROS) production that contributes to cellular stress and damage in astronauts. Average spaceflight mission time is expected to lengthen as humanity aims to visit other planets. However, longer missions or spaceflights will undoubtedly lead to an increment in microgravity, ionizing radiation and ROS production. Strategies to minimize ROS damage are necessary to maintain the health of astronauts, future space colonists, and tourists during and after spaceflight missions. An antioxidant cocktail formulated to prevent or mitigate ROS damage during space exploration could help maintain the health of space explorers. We propose key points to consider when developing an antioxidant cocktail. We discuss how ROS damages our body and organs, the genetic predisposition of astronauts to its damage, characteristics and evidence of the effectiveness of antioxidants to combat excess ROS, differences in drug metabolism when on Earth and in space that could modify antioxidant effects, and the characteristics and efficacy of common antioxidants. Based on this information we propose a workflow for assessing astronaut resistance to ROS damage, infight monitoring of ROS production, and an antioxidant cocktail. Developing an antioxidant cocktail represents a big challenge to translate current medical practices from an Earth setting to space. The key points presented in this review could promote the development of different antioxidant formulations to maintain space explorers' health in the future