10 research outputs found
Polysulfates block SARSâCoVâ2 uptake through electrostatic interactions
- Author
- Achazi K.
- Amin M.
- Andreano E.
- Baba M.
- Benesch J. L. P.
- Bhatia S.
- Cagno V.
- Cagno V.
- Cao Y.
- Chu H.
- Clausen T. M.
- Dernedde J.
- Donskyi I.
- Donskyi I. S.
- Gu H.
- Hoffmann M.
- Jin L.
- Jones S. T.
- Kim S. Y.
- Koehler M.
- Kwon P. S.
- Lan J.
- Lemos A. C. B.
- Ma L.
- Manning G. S.
- Nahmias A. J.
- Oduah E. I.
- Paolisso P.
- Pouyan P.
- Record M. T.
- Rosenberg R. D.
- Shang J.
- Tang Z.
- Thachil J.
- Tree J. A.
- TĂŒrk H.
- Wallert M.
- Wang C.
- Wang G.
- Wei Q.
- Wei Q.
- Wölfel R.
- Xu X.
- Xu X.
- Xu X.
- Yang Y.
- Zhu N.
- Ziem B.
- Publication venue
- Publication date
- 01/01/2021
- Field of study
Get PDFHere we report that negatively charged polysulfates can bind to the spike protein of SARS-CoV-2 via electrostatic interactions. Using a plaque reduction assay, we compare inhibition of SARS-CoV-2 by heparin, pentosan sulfate, linear polyglycerol sulfate (LPGS) and hyperbranched polyglycerol sulfate (HPGS). Highly sulfated LPGS is the optimal inhibitor, with a half-maximal inhibitory concentration (IC50) of 67 ÎŒg/mL (approx. 1.6 ÎŒM). This synthetic polysulfates exhibit more than 60-fold higher virus inhibitory activity than heparin (IC50: 4084 ÎŒg/mL), along with much lower anticoagulant activity. Furthermore, in molecular dynamics simulations, we verified that LPGS can bind stronger to the spike protein than heparin, and that LPGS can interact even more with the spike protein of the new N501Y and E484K variants. Our study demonstrates that the entry of SARS-CoV-2 into host cells can be blocked via electrostatic interaction, therefore LPGS can serve as a blueprint for the design of novel viral inhibitors of SARS-CoV-2
Ăber die Wirkung von Barbituraten bei Ratten verschiedenen Alters
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1969
- Field of study
No full textSystemische Heparingabe mildert die radiogene Mucositis enoralis im Mausmodell durch Interaktion mit Repopulierungsprozessen
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
No full textPolysulfates Block SARSâCoVâ2 Uptake through Electrostatic Interactions**
- Author
- Achazi K.
- Amin M.
- Andreano E.
- Baba M.
- Benesch J. L. P.
- Bhatia S.
- Cagno V.
- Cagno V.
- Cao Y.
- Chu H.
- Clausen T. M.
- Dernedde J.
- Donskyi I.
- Donskyi I. S.
- Gu H.
- Hoffmann M.
- Jin L.
- Jones S. T.
- Kim S. Y.
- Koehler M.
- Kwon P. S.
- Lan J.
- Lemos A. C. B.
- Ma L.
- Manning G. S.
- Nahmias A. J.
- Oduah E. I.
- Paolisso P.
- Pouyan P.
- Record M. T.
- Rosenberg R. D.
- Shang J.
- Tang Z.
- Thachil J.
- Tree J. A.
- TĂŒrk H.
- Wallert M.
- Wang C.
- Wang G.
- Wei Q.
- Wei Q.
- Wölfel R.
- Xu X.
- Xu X.
- Xu X.
- Yang Y.
- Zhu N.
- Ziem B.
- Publication venue
- 'Wiley'
- Publication date
- Field of study
No full textPolysulfate hemmen durch elektrostatische Wechselwirkungen die SARSâCoVâ2âInfektion**
- Author
- Achazi K.
- Amin M.
- Andreano E.
- Baba M.
- Benesch J. L. P.
- Bhatia S.
- Cagno V.
- Cao Y.
- Chu H.
- Clausen T. M.
- Dernedde J.
- Donskyi I.
- Donskyi I. S.
- Gu H.
- Hoffmann M.
- Jin L.
- Jones S. T.
- Kim S. Y.
- Koehler M.
- Kwon P. S.
- Lan J.
- Lemos A. C. B.
- Ma L.
- Manning G. S.
- Nahmias A. J.
- Oduah E. I.
- Paolisso P.
- Pouyan P.
- Record M. T.
- Rosenberg R. D.
- Shang J.
- Tang Z.
- Thachil J.
- Tree J. A.
- TĂŒrk H.
- Wallert M.
- Wang C.
- Wang G.
- Wei Q.
- Wei Q.
- Wölfel R.
- Xu X.
- Xu X.
- Xu X.
- Yang Y.
- Zhu N.
- Ziem B.
- Publication venue
- 'Wiley'
- Publication date
- Field of study
No full textIdentical and Nonidentical Twins: Risk and Factors Involved in Development of Islet Autoimmunity and Type 1 Diabetes
- Author
- B. lo
- Aas S.
- Abbondondolo M.
- Adams T.
- Alies P.
- Allen L.
- Amado D.
- Anderson M.
- Antinozzi P.
- Asif I.
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- Badias F.
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- Martin J.
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- Patrick V.
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- Publication venue
- 'American Diabetes Association'
- Publication date
- 01/02/2019
- Field of study
No full textCardiovascular Aspects of Radiolog
Effect of Oral Insulin on Prevention of Diabetes in Relatives of Patients With Type 1 Diabetes A Randomized Clinical Trial
- Author
- B. lo
- Abbondondolo M.
- Adams T.
- Alies P.
- Alkanani A.
- Anderson M.
- Antinozzi P.
- Asif D.A.I.
- Atkinson M.
- Baden L.
- Badias F.
- Baidal D.
- Baker A.
- Barker J.
- Barr M.
- Bassi M.
- Battaglia M.
- Batts E.
- Beam C.
- Beck G.
- Benoist C.
- Betancourt J.
- Bingley P.
- Blau A.
- Blum J.
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- Boonstra M.
- Bosi E.
- Boulware D.
- Bounmananh L.
- Bourcier K.
- Braun J.
- Bream S.
- Brickman W.
- Brillon D.
- Buckner J.
- Bui V.
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- Burke B.
- Burroughs C.
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- Carr L.
- Chase H.
- Chase P.
- Clare-Salzler M.
- Clements M.
- Clynes R.
- Colman P.
- Cowie C.
- Craig C.
- Cuthbertson D.
- Deemer M.
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- Dial M.
- DiMeglio L.
- Drye M.
- Eberhard C.
- Eisenbarth G.
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- Escobar E.
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- Roncarolo M.
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- Santiago I.
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- Shultz A.
- Siegelman M.
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- Zafonte S.J.
- Ziegler A.
- Zimmerman D.
- Zinman B.
- Publication venue
- 'American Medical Association (AMA)'
- Publication date
- 21/11/2017
- Field of study
No full textTransplantation and autoimmunit
The Anticoagulant and Nonanticoagulant Properties of Heparin
- Author
- A Achilles
- A Adam
- A Amirkhosravi
- A Cuker
- A EI Proudfoot
- A Friedl
- A K Kakkar
- A K Lindahl
- A Koenig
- A M Gomes
- A Nelson
- A Sedigh
- A YY Lee
- B Casu
- B M Revelle
- C Ettelaie
- C G Freeman
- C IPR Blaukovitch
- C Kannemeier
- C Longstaff
- C Oschatz
- C PW Klerk
- C Vancheri
- C Wang
- Chris P. Reutelingsperger
- D Alonso
- D B Pfankuchen
- D R Coombe
- D Sanford
- Danielle M. H. Beurskens
- E I Oduah
- E Lefkou
- E M Stewart
- E Marciniak
- E Seyrek
- E Tkachenko
- E Young
- F Macbeth
- F Redini
- G AF Nicolaes
- G Cassinelli
- G J Cole
- G Meyer
- G MT Chang
- G S Aldea
- G SV Kuschert
- Gerry A. F. Nicolaes
- H H Lipowsky
- H Hochart
- H JM Groen
- H. Coenraad Hemker
- I Manduteanu
- I Stelmach
- J Aznar
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- J Li
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- Joram P. Huckriede
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- L Borsig
- L H Lam
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- L Thunberg
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- M D Stewart
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- M J Morgan
- M J Sculpher
- M Kato
- M Kragh
- M L von BrĂŒhl
- M Ledson
- M Levi
- M M Kemp
- M P Skinner
- M S Diamond
- M Saffarzadeh
- M Schindewolf
- M Schlesinger
- M X Wan
- N G dela Paz
- N Kitamura
- N M Kuderer
- N S Quinsey
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- O Ostrovsky
- O Saksela
- P Andrade-Gordon
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- P M Sandset
- P RB Joseph
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- P Zhou
- Q-YFE Hu
- R Al Dieri
- R Alyahya
- R C Becker
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- R J Linhardt
- R J Ludwig
- R Lever
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- R M Nelson
- R TS Lakshmi
- R Wagenvoord
- R Zarychanski
- Roy Schrijver
- S A Mousa
- S A Smith
- S A Smith
- S Bertini
- S Bertini
- S J Miller
- S Laporte
- S Lederman
- S R Coughlin
- S Soker
- S T Olson
- S W Rathbun
- S Yini
- T Iba
- T Liu
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- V Brinkmann
- V Kanabar
- V V Kiselyov
- W E Connor
- W Li
- W Y Liao
- X Chen
- X Li
- X Li
- X Xie
- Y B Ăzkurt
- Y Fan
- Y Pan
- Y Yang
- Y Yu
- Z Chen
- Z G Luan
- Z Luan
- Z Shriver
- Publication venue
- 'Georg Thieme Verlag KG'
- Publication date
- Field of study
No full textAnesthesia
- Author
- A Carlsson
- A Driessen
- A DâHollander
- A Granath
- A Mansell
- AB Froese
- AD McLaren
- AG Shapiro
- AH Giesecke
- AJ Linzbach
- AJ Linzbach
- AJ Marshall
- AM Master
- AS Keats
- AW Gelb
- B Landauer
- B Weiss
- BA Shapiro
- BA Shapiro
- BE Herman
- BE Marshall
- BE Tomlinson
- BG Covino
- BL Beattie
- Boston collaborative surveillance program
- BR Simpson
- C Emirgil
- C Kallina
- C Prys-Roberts
- CA Carmack
- CB Assidao
- CJ Vacanti
- CL Cogbill
- CR Stephen
- D Jung
- D Michel
- DC Chung
- DC Chung
- DC Finlayson
- DG Lappas
- DH Tyras
- DJ Greenblatt
- DL Bruce
- DR Stanski
- DT Mangano
- DV Pecora
- E Kraas
- E Lowenstein
- E RĂŒgheimer
- E RĂŒgheimer
- E RĂŒgheimer
- E RĂŒgheimer
- E Salehi
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- H Lutz
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- JM Turner
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- K Chan
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- KG Pulver
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- L Goldman
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- LRM Guerico Del
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- M Brandi
- M Brandi
- M Oduah
- MA Welch
- MB Laver
- MB Laver
- MF Roizen
- MF Weiss
- MJ Hensley
- MJ Mihalick
- MJ Tompkins
- MM Reidenberg
- MS Islam
- N Beer
- NE Bille Brahe
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- P Hamer
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- P Lawin
- P Lawin
- P Leblanc
- PA Steen
- PE Vanik
- PH Lorhan
- PH Lorhan
- PM Osswald
- PR Bromage
- PR Bromage
- PW Herrion
- R Begin
- R Dudziak
- R Miller
- R Virtanen
- RD Dripps
- RD Miller
- RH Bartlett
- RJ Wilder
- RK Stoelting
- RR Richard
- RS Kronenberg
- RW Miller
- S Deutsch
- S Fitzal
- S Hoyer
- S Muravchick
- S Palmberg
- S Tarhan
- SC Farrow
- T Pasch
- T StefĂąnsson
- T StefĂąnsson
- T StefĂąnsson
- TM Murphy
- TW Feeley
- U Klotz
- U Morr-Strathmann
- U Morr-Strathmann
- V Braun
- V Ehehalt
- VC Hachinski
- W Chowanetz
- W Hartung
- W Schimmler
- W Seeling
- W Tolksdorf
- WA Wallace
- WB Kannel
- WC Stevens
- WD Owens
- WE Powers
- WH Marshall
- WJ OâDonohue
- WT Ulmer
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1984
- Field of study
No full textSulfated Non-Saccharide Glycosaminoglycan Mimetics as Novel Drug Discovery Platform for Various Pathologies
- Author
- Abdeen S.
- Abdel Aziz M.H.
- Abdel Aziz M.H.
- Abushakra S.
- Afosah D.K.
- Afosah D.K.
- Agostino M.
- Al-Horani R.A.
- Al-Horani R.A.
- Al-Horani R.A.
- Al-Horani R.A.
- Al-Horani R.A.
- Al-Horani R.A.
- Al-Horani R.A.
- Al-Horani R.A.
- Al-Horani R.A.
- Al-Horani R.A.
- Al-Horani R.A.
- Al-Horani R.A.
- Aleman M.M.
- Almeida J.R.
- Aquino R.S.
- Arocas V.
- Asada M.
- Badellino K.O.
- Bauer P.I.
- Belting M.
- Blossom D.B.
- Bock P.E.
- Boothello R.S.
- Bourin M.C.
- Brown A.
- Byrnes J.R.
- Capila I.
- Cardin A.D.
- Carter W.J.
- Caterson B.
- Chander A.
- Choay J.
- Choudhary S.
- Correia-da-Silva M.
- Correia-da-Silva M.
- Correia-da-Silva M.
- Correia-da-Silva M.
- Crublet E.
- Daniel K. Afosah
- Dasgupta J.
- De Candia E.
- de Paz J.L.
- DeAngelis P.L.
- DeAngelis P.L.
- Desai U.R.
- Desai U.R.
- Desai U.R.
- Di Cera E.
- Emsley J.
- Ernst B.
- Ersdal-Badju E.
- Esko J.D.
- Esmon C.T.
- Fath M.A.
- Ferla S.
- Fischer B.M.
- Flick M.J.
- Fromm J.R.
- Fromm J.R.
- Frommherz K.J.
- Fu L.
- Gailani D.
- Gan Z.R.
- Gandhi N.S.
- Gangji R.N.
- Gettins P.G.W.
- Gozzo A.J.
- Guerrini M.
- Gunnarsson G.T.
- Gunnarsson G.T.
- Gunnarsson G.T.
- Gunnarsson G.T.
- Gunnarsson G.T.
- Gustafsen C.
- Hauske P.
- He R.
- Hedstrom L.
- Henry B.L.
- Henry B.L.
- Henry B.L.
- Henry B.L.
- Hileman R.E.
- Hileman R.E.
- Ho D.H.
- Holzmann J.
- Hoogewerf A.J.
- Hu Y.P.
- Huntington J.A.
- Imberty A.
- Jackson R.L.
- Jin L.
- Jinno A.
- Johnson D.J.
- Johnson D.J.
- Johnson Z.
- Jordan R.E.
- Karuturi R.
- Khatun Z.
- Kim M.
- Kim S.K.
- Kim S.K.
- Kishimoto T.K.
- Koester D.C.
- Kostoulas G.
- Krieger E.
- Kuschert G.S.
- Lane D.A.
- Lauer P.
- Lee Y.
- Lever R.
- Li W.
- Li W.
- Liang A.
- Liang W.G.
- Lima R.T.
- Liu H.
- Liu J.
- Loscalzo J.
- Luster A.D.
- Machovich R.
- Magnani J.L.
- Malik A.
- Margalit H.
- Mathias D.K.
- Matos P.M.
- Mayo K.H.
- McCoy A.J.
- Mehta A.Y.
- Mehta A.Y.
- Mehta A.Y.
- Mende M.
- Merdanovic M.
- Mizumoto S.
- Monien B.H.
- Monien B.H.
- Monien B.H.
- Monslow J.
- Motlekar N.A.
- Motlekar N.A.
- Moulard M.
- Mulloy B.
- Nagarajan B.
- Nahain A.A.
- Naviaux R.K.
- Nelson R.M.
- Neves A.R.
- Nordenman B.
- Oduah E.I.
- Olson S.T.
- Olson S.T.
- Ornitz D.M.
- OâBrien L.A.
- Pan J.
- Pantoliano M.W.
- Patel N.J.
- Patel N.J.
- Pellegrini L.
- Pervin A.
- Petitou M.
- Plosker G.L.
- Pomin V.H.
- Pratt C.W.
- Rabenstein D.L.
- Raghuraman A.
- Raghuraman A.
- Raman K.
- Raman R.
- Rami A. Al-Horani
- Rees C.R.
- Rezaie A.R.
- Rollins B.J.
- Rondanin R.
- Rosenberg R.D.
- Rossi D.
- Rumjon A.
- Ruoslahti E.
- Sabroe I.
- Saluja B.
- Saluja B.
- Samsonov S.A.
- Sankaranarayanan N.V.
- Sankaranarayanan N.V.
- Sarkar A.
- Sasisekharan R.
- Sasisekharan R.
- Schlessinger J.
- Severin I.C.
- Sheehan J.P.
- Shen A.
- Shukla D.
- Shukla D.
- Shute J.
- Sidhu P.S.
- Sidhu P.S.
- Smith G.F.
- Sobel M.
- Spencer J.L.
- Thompson L.D.
- Tiwari V.
- Tiwari V.
- Tollefsen D.M.
- Truong T.M.
- Tuder R.M.
- Turk B.
- Turner N.
- Verespy S.
- Verghese J.
- Verhamme I.M.
- Versteeg H.H.
- Vilas-Boas C.
- Volpi N.
- Volpi N.
- von dem Borne P.A.
- Walsh R.L.
- Weitz J.I.
- Wells T.N.
- Witt D.P.
- Witvrouw M.
- Wu L.
- WuDunn D.
- Yasuda T.
- Yin J.
- Yip G.W.
- Yomtova V.M.
- Zhang L.
- Zhao M.
- Publication venue
- 'Bentham Science Publishers Ltd.'
- Publication date
- Field of study
No full text
