Narrating Diaspora. The African Diaspora as a Counter-Narrative

This paper’s central goal is to examine the role that narratives, collective or other-wise, play in the construction of diaspora as an epistemic formation. In particular, we are interested in exploring the interplay between dominant narratives on diaspora and competing counter-narratives of diaspora. In order to do this, we resort to the concept of “imagined communities” by Benedict Anderson, arguing that the sense of a communion among members of communities is buttressed in collective narratives based on shared knowledge, values, norms, and culture. Furthermore, the paper draws on a typology developed by Carolin Gebauer and Roy Sommer which differentiates between narratives on and stories of migration. Adopting this distinction, we argue that narratives on diaspora provide a primarily etic (i.e., outsider) perspective on diasporic formations, as they emphasize group cohesion and a sense of shared group consciousness that unites members of diasporic communities. Such narratives are often found in academic scholarship and in public discourses about diaspora. By contrast, narratives of diaspora refer to discourses that provide an emic (i.e., insider) perspective, acknowledging the diversity and historicity of diasporic formations and their roles as epistemic communities. This emic perspective foregrounds historical ‘moments’ that have led to the development of the African diaspora in Germany, which articulates counter-narratives to various discourses, especially anti-Black racism

Hydrogeochemical processes in groundwater in Uganda: a national-scale analysis

Groundwater represents a vital source of freshwater to meet distributed, rapidly rising demands for safe drinking water, irrigation and industry in low-income countries across the tropics. The hydrochemistry of groundwater within deeply weathered crystalline rock aquifer systems that predominate at low latitudes, is determined primarily by long-term biogeochemical weathering of the parent bedrock. Here, we evaluate geochemical footprints and baseline chemical quality of groundwater that have developed from water-rock interactions across a range of geological environments in Uganda using a national database of hydrochemical and hydrogeological records from 3271 locations. Sampled groundwaters are mostly shallow (69% of samples from depths of <20 m below ground level), fresh at time of drilling (Electrical Conductivity <1000 μS cm−1 in 96% of samples), and of good quality (<8% of samples exceed WHO (2011) guidelines values for chemical parameters in drinking water). Unpalatably high concentrations of total soluble and suspended Fe are, however, common (21%) in meta-igneous, granitic and metamorphic formations. The dominant (95%) anionic facies of groundwater is bicarbonate (HCO3−), indicative of localized flow systems (i.e. discontinuous aquifers) in which chemical evolution of groundwater (e.g. as per Chebotarev sequence) is minimal. Low well yields (82% < 3.6 m3 h−1) and specific capacities (84% < 5 m2 d−1) support this inference; low aquifer transmissivities and storage serve to regulate naturally groundwater withdrawals (i.e. impacts of over-abstraction are localized). Overall, the results attest to the intrinsic high quality of groundwater that occurs in deeply weathered crystalline rock environments in Uganda, which may be expected across tropical Africa

The effect of anthelmintic treatment during pregnancy on HIV plasma viral load: results from a randomized, double-blind, placebo-controlled trial in Uganda.

BACKGROUND: To investigate the effect of helminth infections and their treatment during pregnancy on HIV load, we conducted a 2 × 2 factorial randomized controlled trial of albendazole versus placebo and praziquantel versus placebo in pregnant women in Entebbe, Uganda. METHODS: Two hundred sixty-four HIV-infected pregnant women from the Entebbe Mother and Baby Study (ISRCTN 32849447) were included in this analysis. Women were tested for helminth infections at enrollment, and mean HIV load was compared between infected and uninfected groups. The effect of anthelmintic treatment on HIV load was evaluated at 6 weeks after treatment and at delivery using linear regression and adjusting for enrollment viral load. RESULTS: Hookworm and Trichuris infections were associated with higher mean viral load at enrollment [adjusted mean difference 0.24 log10 copies/mL, 95% confidence interval (CI): 0.01 to 0.47, P = 0.03, and 0.37 log(10) copies/mL, 95% CI: 0.00 to 0.74, P = 0.05, respectively]. There were no associations between viral load and other helminth species. There was some evidence that albendazole reduced viral load at 6 weeks after treatment (adjusted mean difference -0.17, 95% CI: -0.36 to 0.01, P = 0.07); however, this effect did not differ according to mother's hookworm infection status and had diminished at delivery (adjusted mean difference -0.11, 95% CI: -0.28 to 0.07, P = 0.23). There was no effect of praziquantel treatment on HIV load at any time point. CONCLUSIONS: Infection with some soil-transmitted helminth species is associated with increased HIV load in pregnancy. Treatment with albendazole causes a small decrease in HIV load; however, this may not represent a direct effect of worm removal

The potential for the double risk of rabies and antimicrobial resistance in a high rabies endemic setting:Detection of antibiotic resistance in bacterial isolates from infected dog bite wounds in Uganda

BACKGROUND: Post-exposure treatment for dog bites in humans aims at alleviating the risk of rabies and promoting wound healing. Wound healing may be complicated by bacteria. This study identified the different bacteria and their antibiotic susceptibilities in infected dog bite wounds (DBWs) in Uganda. METHODS: A cross-sectional study was conducted among 376 dog bite patients. Wound swabs from patients with infected DBWs were collected and inoculated into recommended media. They were cultured for both aerobic and anaerobic bacteria. All isolated bacteria were identified based on colony characteristics, gram stain, and standard biochemical tests. Molecular identification was performed for strains that were resistant to three or more antibiotics. Antibiotic susceptibility testing was conducted using the disc diffusion method following the modified Kirby-Bauer method. The data were analysed using Stata version 15 software. RESULTS: Approximately half of the patients (52.9%, 199/376) presented with infected wounds. Majority of the swabs (84.4%, 168/199) were culture positive, and yielded a total of 768 isolates where about half (52.9%, 406/768) were gram positive bacteria, and about two-thirds (64.6%, 496/768) were recovered from category II wounds. Among the gram positive bacteria, 339 (83.5%) were aerobes where Staphylococcus aureus (103, 30.4%), Coagulase-negative staphylococci (68, 20.1%), and Corynebacterium spp (33, 9.7%) had the highest prevalence. For the 362 Gram negative isolates, 217 (59.9%) were aerobes and the commonest isolates were P. maltocida (64, 29.5%), Capnocytophaga canimorsus (36, 16.6%) and P. canis (26, 12.0%). Gram-positive isolates were resistant to metronidazole (93.6%), oxacillin (68.5%), ceftriaxone (14.6%) and amoxicillin/clavulanic acid (14.0%). Gram negative isolates were resistant to metronidazole (100%), ampicillin (30.7%), oxacillin (29.3%), and doxycycline (22.9%). Multidrug resistance was in 105 (29.0%) and 121/406 (29.8%) of the gram-negative and gram-positive isolates, respectively. All gram-positive isolates were susceptible to vancomycin and ciprofloxacin. CONCLUSIONS: Infection rates of DBWs in Uganda are high and the dominant bacterial isolates are Staphylococcus aureus, Pasteurella spps, and Capnocytophaga canimorsus. Multidrug resistance to commonly used antibiotics is high. The recommendation in the Uganda Clinical Guidelines to use metronidazole in the management of DBWs should be reviewed. DBWs should be enlisted for routine antimicrobial resistance surveillance and rational use of antimicrobial agents should be promoted. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13756-022-01181-0

Championing urban farmers in Kampala. Influences on local policy change in Uganda. Process and partnership for pro-poor policy change

This working paper presents an analysis of actors, events and influences affecting a policy change on urban agriculture in Kampala. It reviews the policy and institutional changes related to urban agriculture that occurred in Kampala from 1990 to 2006, and examines how and why they came about. The approach used here combined elements of three established methodologies, viz, episode studies; case study analysis; and outcome mapping. For this case study, the episode study component was central, with the case study and outcome mapping components used to cross-check and deepen the analysis. This information was assembled into three overlapping narratives: 1. A timeline of activities that played a role in changing attitudes and behaviour towards urban agriculture. 2. An analysis of the development of policies affecting urban agriculture in Kampala including the new ordinances. 3. A description of behaviour change of key actors related to the policy change These were summarised in a visual representation of the process and influences and analysed using a framework emphasising political context and the roles of evidence, linkages and external environment

Vorkommen von Spurenelementen in Flusssedimenten und Grund- und Oberflächenwasser in der Bergbauregion von Gatumba, Ruanda

Aufgrund der intensiven Landnutzung durch Bergbau und Landwirtschaft sind die Gewässer im Gatumba Mining District durch Stoffaustrag aus Abraumhalden und Erosion stark geprägt. Untersuchungen während einer Trocken- und Regenzeit hinsichtlich der Konzentration von Spurenelemente haben gezeigt, dass von einer Gesundheitsgefährdung der lokalen Bevölkerung derzeit nicht ausgegangen werden kann. In der Regel weisen die Wasserproben der Trockenzeit gegenüber denen der Regenzeit tendenziell höhere Konzentrationen auf. Die Konzentrationen der Sedimente zeigen keinen entsprechenden Trend

The impact of maternal infection with Mycobacterium tuberculosis on the infant response to bacille Calmette-Guérin immunization.

Bacille Calmette-Guérin (BCG) immunization provides variable protection against tuberculosis. Prenatal antigen exposure may have lifelong effects on responses to related antigens and pathogens. We therefore hypothesized that maternal latent Mycobacterium tuberculosis infection (LTBI) influences infant responses to BCG immunization at birth. We measured antibody (n = 53) and cellular (n = 31) responses to M. tuberculosis purified protein derivative (PPD) in infants of mothers with and without LTBI, in cord blood and at one and six weeks after BCG. The concentrations of PPD-specific antibodies declined between birth (median [interquartile range (IQR)]) 5600 ng ml(-1) [3300-11 050] in cord blood) and six weeks (0.00 ng ml(-1) [0-288]). Frequencies of PPD-specific IFN-γ-expressing CD4(+)T cells increased at one week and declined between one and six weeks (p = 0.031). Frequencies of IL-2- and TNF-α-expressing PPD-specific CD4(+)T cells increased between one and six weeks (p = 0.019, p = 0.009, respectively). At one week, the frequency of PPD-specific CD4(+)T cells expressing any of the three cytokines, combined, was lower among infants of mothers with LTBI, in crude analyses (p = 0.002) and after adjusting for confounders (mean difference, 95% CI -0.041% (-0.082, -0.001)). In conclusion, maternal LTBI was associated with lower infant anti-mycobacterial T-cell responses immediately following BCG immunization. These findings are being explored further in a larger study

Effects of maternal and infant co-infections, and of maternal immunisation, on the infant response to BCG and tetanus immunisation.

Some vaccines show poor efficacy in tropical countries. Within a birth cohort in Uganda, we investigated factors that might influence responses to BCG and tetanus immunisation. Whole blood assay responses to crude culture filtrate proteins of Mycobacterium tuberculosis (cCFP)) and tetanus toxoid (TT) were examined among 1506 and 1433 one-year-olds, respectively. Maternal Mansonella perstans infection was associated with higher interleukin (IL)-10 responses to both immunogens but no reduction in gamma interferon (IFN-γ), IL-5 and IL-13 responses; other maternal helminth infections showed little effect. Tetanus immunisation during pregnancy was associated with higher infant responses to TT; maternal BCG scar (from past immunisation) with lower infant IL-5 and IL-13 responses to cCFP. IFN-γ, IL-5 and IL-13 to TT were reduced in HIV-exposed-uninfected infants; infant malaria and HIV were associated with lower IFN-γ, IL-5 and IL-13 responses to both immunogens. We conclude that maternal helminth infections are unlikely to explain poor vaccine efficacy in the tropics. Effects of maternal immunisation on infant responses to vaccines should be explored. Prevention of infant malaria and HIV could contribute to effectiveness of immunisation programmes