Ступінь приверженості до лікування та його ефективність у пацієнтів з гіпертонічною хворобою залежно від способу життя

Vitamin C is a widely used vitamin. Here we review the occurrence and properties of aldonolactone oxidoreductases, an important group of flavoenzymes responsible for the ultimate production of vitamin C and its analogs in animals, plants, and single-cell organisms

Circadian oscillator proteins across the kingdoms of life : Structural aspects 06 Biological Sciences 0601 Biochemistry and Cell Biology

Circadian oscillators are networks of biochemical feedback loops that generate 24-hour rhythms and control numerous biological processes in a range of organisms. These periodic rhythms are the result of a complex interplay of interactions among clock components. These components are specific to the organism but share molecular mechanisms that are similar across kingdoms. The elucidation of clock mechanisms in different kingdoms has recently started to attain the level of structural interpretation. A full understanding of these molecular processes requires detailed knowledge, not only of the biochemical and biophysical properties of clock proteins and their interactions, but also the three-dimensional structure of clockwork components. Posttranslational modifications (such as phosphorylation) and protein-protein interactions, have become a central focus of recent research, in particular the complex interactions mediated by the phosphorylation of clock proteins and the formation of multimeric protein complexes that regulate clock genes at transcriptional and translational levels. The three-dimensional structures for the cyanobacterial clock components are well understood, and progress is underway to comprehend the mechanistic details. However, structural recognition of the eukaryotic clock has just begun. This review serves as a primer as the clock communities move towards the exciting realm of structural biology

The effects of smoothing length on the onset of wave breaking in smoothed particle hydrodynamics (SPH) simulations of highly directionally spread waves

Ocean wave breaking is a difficult-to-model oceanographic process, which has implications for extreme wave statistics, the dissipation of wave energy, and air–sea interaction. Numerical methods capable of reliably simulating real-world directionally spread breaking waves are useful for investigating the physics of wave breaking and for the design of offshore structures and floating bodies. Smoothed particle hydrodynamics is capable of modelling highly steep and overturning free surfaces, which makes it a promising method for simulating breaking waves. This paper investigates the effect of smoothing length on simulated wave breaking in both following and crossing seas. To do so, we reproduce numerically the experiments of highly directionally spread breaking waves in McAllister et al. (J Fluid Mech 860:767–786, 2019. https://doi.org/10.1017/jfm.2018.886) using a range of normalised smoothing lengths: h/ dp= 1.4 , 1.7, 2.0, 2.3, with h smoothing length and dp particle spacing. The smallest smoothing length we use appears to adversely affect the fidelity of the simulated surface elevation, so that the tallest wave crest observed in experiments is not fully reproduced (coefficient of determination r2≈ 0.7). For smoothing lengths h/ dp= 1.7 , 2.0, and 2.3, the experiments are well reproduced (r2≥ 0.88); in these simulations smoothing length predominantly affects the spatial extent and duration of breaking. Qualitative and quantitative comparison of our simulations shows that values of h/ dp in the range 1.7 - 2 best reproduce the wave breaking phenomena observed in experiments.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Environmental Fluid Mechanic