25 research outputs found
Cannabinoid-based drugs targeting CB1 and TRPV1, the sympathetic nervous system, and arthritis
Engineering of Fermi level by nin diamond junction for control of charge states of NV centers
The charge-state control of nitrogen-vacancy (NV) centers in diamond is very important toward its applications because the NV centers undergo stochastic charge-state transitions between the negative charge state (NV⁻) and the neutral charge state (NV⁰) of the NV center upon illumination. In this letter, engineering of the Fermi level by a nin diamond junction was demonstrated for the control of the charge state of the NV centers in the intrinsic (i) layer region. By changing the size (d) of the i-layer region between the phosphorus-doped n-type layer regions (nin) from 2 μm to 10 μm, we realized the gradual change in the NV− charge-state population in the i-layer region from 60% to 80% under 532 nm excitation, which can be attributed to the band bending in the i-layer region. Also, we quantitatively simulated the changes in the Fermi level in the i-layer region depending on d with various concentrations of impurities in the i-layer region
Age dependence of the hydraulic resistances of the plasma membrane and the tonoplast (vacuolar membrane) in cells of Chara corallina
Osmotic water permeability of plasma and vacuolar membranes in protoplasts II. Theoretical basis
Temperature influences the ability of tall fescue to control transpiration in response to atmospheric vapour pressure deficit
Achiral Counterion Control of Enantioselectivity in a Brønsted Acid-Catalyzed Iodolactonization
Low soil temperature reducing the yield of drip irrigated rice in arid area by influencing anther development and pollination
Brønsted Acid Catalyzed Phosphoramidic Acid Additions to Alkenes: Diastereo- and Enantioselective Halogenative Cyclizations for the Synthesis of C
Delayed allogeneic skin graft rejection in CD26-deficient mice
Organ transplantation is an effective therapeutic tool for treating many terminal diseases. However, one of the biggest challenges of transplantation is determining how to achieve the long-term survival of the allogeneic or xenogeneic transplant by, for example, preventing transplant rejection. In the current study, CD26 gene-knockout mice were used to investigate the potential role of CD26/dipeptidyl peptidase-4 (DPPIV) in allogeneic skin graft rejection by tail-skin transplantation. Compared with wild-type (CD26(+/+)) counterparts, CD26(–/–) mice showed reduced necrosis of grafts and delayed graft rejection after skin transplantation. Concentrations of serum IgG, including its subclasses IgG1 and IgG2a, were significantly reduced in CD26(–/–) mice during graft rejection. Moreover, after allogeneic skin transplantation, the secretion levels of the cytokines IFN-γ, IL-2, IL-6, IL-4, and IL-13 were significantly reduced, whereas the level of the cytokine IL-10 was increased in the serum of CD26(–/–) mice compared with that in the serum of CD26(+/+) mice. Additionally, the concentration of IL-17 in serum and the percentage of cells secreting IL-17 in mouse peripheral blood lymphocytes (MPBLs) were both significantly lower, while the percentage of regulatory T cells (Tregs) was significantly higher in MPBLs of CD26(–/–) mice than in those of CD26(+/+) mice. Furthermore, a lower percentage of CD8(+) T cells in MPBLs and fewer infiltrated macrophages and T cells in graft tissues of CD26(–/–) mice were detected during graft rejection. These results indicate that CD26 is involved in allogeneic skin graft rejection and provides another hint that CD26 deficiency leads to less rejection due to lower activation and proliferation of host immune cells