340 research outputs found
Studi Perbandingan Back Propogation
Keberhasilan pemahaman tentang bagaimana membuat komputer belajar akan membuka banyak
manfaat baru dari komputer. Sebuah pemahaman yang rinci tentang algoritma pengolahan informasi
untuk pembelajaran mesin dapat membuat pemahaman yang sebaik kemampuan belajar manusia.
Banyak jenis pembelajaran mesin yang kita tahu, beberapa diantaranya adalah Backpropagation (BP),
Extreme Learning Machine (ELM), dan Support Vector Machine (SVM). Penelitian ini menggunakan
lima data yang memiliki beberapa karakteristik. Hasil penelitian ini, dari ketiga model yang diamati
memberikan akurasi klasifikasi yang sebanding. Penelitian ini memiliki tiga kesimpulan, yang terbaik
dalam akurasi adalah BP, yang terbaik dalam stabilitas adalah SVM dan CPU time terbaik adalah
ELM untuk data bioinformatika
Inelastic transport theory from first-principles: methodology and applications for nanoscale devices
We describe a first-principles method for calculating electronic structure,
vibrational modes and frequencies, electron-phonon couplings, and inelastic
electron transport properties of an atomic-scale device bridging two metallic
contacts under nonequilibrium conditions. The method extends the
density-functional codes SIESTA and TranSIESTA that use atomic basis sets. The
inelastic conductance characteristics are calculated using the nonequilibrium
Green's function formalism, and the electron-phonon interaction is addressed
with perturbation theory up to the level of the self-consistent Born
approximation. While these calculations often are computationally demanding, we
show how they can be approximated by a simple and efficient lowest order
expansion. Our method also addresses effects of energy dissipation and local
heating of the junction via detailed calculations of the power flow. We
demonstrate the developed procedures by considering inelastic transport through
atomic gold wires of various lengths, thereby extending the results presented
in [Frederiksen et al., Phys. Rev. Lett. 93, 256601 (2004)]. To illustrate that
the method applies more generally to molecular devices, we also calculate the
inelastic current through different hydrocarbon molecules between gold
electrodes. Both for the wires and the molecules our theory is in quantitative
agreement with experiments, and characterizes the system-specific mode
selectivity and local heating.Comment: 24 pages, 17 figure
Nonequilibrium resonant spectroscopy of molecular vibrons
Quantum transport through single molecules is essentially affected by
molecular vibrations. We investigate the behavior of the prototype single-level
model with intermediate electron-vibron coupling and arbitrary coupling to the
leads. We have developed a theory which allows to explore this regime via the
nonequilibrium Green function formalism. We show that the nonequilibrium
resonant spectroscopy is able to determine the energies of molecular orbitals
and the spectrum of molecular vibrations. Our results are relevant to scanning
tunneling spectroscopy experiments, and demonstrate the importance of the
systematic and self-consistent investigation of the effects of the vibronic
dynamics onto the transport through single molecules.Comment: 4 pages, 5 figures, submitte
Establishment of a patient-derived orthotopic Xenograft (PDOX) model of HER-2-positive cervical cancer expressing the clinical metastatic pattern.
Squamous cell carcinoma of the cervix, highly prevalent in the developing world, is often metastatic and treatment resistant with no standard treatment protocol. Our laboratory pioneered the patient-derived orthotopic xenograft (PDOX) nude mouse model with the technique of surgical orthotopic implantation (SOI). Unlike subcutaneous transplant patient-derived xenograft (PDX) models, PDOX models metastasize. Most importantly, the metastasis pattern correlates to the patient. In the present report, we describe the development of a PDOX model of HER-2-positive cervical cancer. Metastasis after SOI in nude mice included peritoneal dissemination, liver metastasis, lung metastasis as well as lymph node metastasis reflecting the metastatic pattern in the donor patient. Metastasis was detected in 4 of 6 nude mice with primary tumors. Primary tumors and metastases in the nude mice had histological structures similar to the original tumor and were stained by an anti-HER-2 antibody in the same pattern as the patient's cancer. The metastatic pattern, histology and HER-2 tumor expression of the patient were thus preserved in the PDOX model. In contrast, subcutaneous transplantation of the patient's cervical tumors resulted in primary growth but not metastasis
Tumor-Targeting Salmonella typhimurium A1-R in Combination with Trastuzumab Eradicates HER-2-Positive Cervical Cancer Cells in Patient-Derived Mouse Models.
We have previously developed mouse models of HER-2-positive cervical cancer. Tumors in nude mice had histological structures similar to the original tumor and were stained by anti-HER-2 antibody in the same pattern as the patient's cancer. We have also previously developed tumor-targeting Salmonella typhimurium A1-R and have demonstrated its efficacy against patient-derived tumor mouse models, both alone and in combination. In the current study, we determined the efficacy of S. typhimurium A1-R in combination with trastuzumab on a patient-cancer nude-mouse model of HER-2 positive cervical cancer. Mice were randomized to 5 groups and treated as follows: (1) no treatment; (2) carboplatinum (30 mg/kg, ip, weekly, 5 weeks); (3) trastuzumab (20 mg/kg, ip, weekly, 5 weeks); (4) S. typhimurium A1-R (5 × 107 CFU/body, ip, weekly, 5 weeks); (5) S. typhimurium A1-R (5 × 107 CFU/body, ip, weekly, 5 weeks) + trastuzumab (20 mg/kg, ip, weekly, 5 weeks). All regimens had significant efficacy compared to the untreated mice. The relative tumor volume of S. typhimurium A1-R + trastuzumab-treated mice was smaller compared to trastuzumab alone (p = 0.007) and S. typhimurium A1-R alone (p = 0.039). No significant body weight loss was found compared to the no treatment group except for carboplatinum-treated mice (p = 0.021). Upon histological examination, viable tumor cells were not detected, and replaced by stromal cells in the tumors treated with S. typhimurium A1-R + trastuzumab. The results of the present study suggest that S. typhimurium A1-R and trastuzumab in combination are highly effective against HER-2-expressing cervical cancer
Proceedings of the Salford Postgraduate Annual Research Conference (SPARC) 2011
These proceedings bring together a selection of papers from the 2011 Salford Postgraduate Annual Research Conference(SPARC). It includes papers from PhD students in the arts and social sciences, business, computing, science and engineering, education, environment, built environment and health sciences. Contributions from Salford researchers are published here alongside papers from students at the Universities of Anglia Ruskin, Birmingham City, Chester,De Montfort, Exeter, Leeds, Liverpool, Liverpool John Moores and Manchester
Mechanism for the Suppression of Intermediate-Mass Black Holes
A model for the formation of supermassive primordial black holes in galactic
nuclei with the simultaneous suppression of the formation of intermediate-mass
black holes is presented. A bimodal mass function for black holes formed
through phase transitions in a model with a "Mexican hat" potential has been
found. The classical motion of the phase of a complex scalar field during
inflation has been taken into account. Possible observational manifestations of
primordial black holes in galaxies and constraints on their number are
discussed.Comment: 12 pages, 2 figure
Evolution of supermassive black holes
Supermassive black holes (SMBHs) are nowadays believed to reside in most
local galaxies, and the available data show an empirical correlation between
bulge luminosity - or stellar velocity dispersion - and black hole mass,
suggesting a single mechanism for assembling black holes and forming spheroids
in galaxy halos. The evidence is therefore in favour of a co-evolution between
galaxies, black holes and quasars. In cold dark matter cosmogonies, small-mass
subgalactic systems form first to merge later into larger and larger
structures. In this paradigm galaxy halos experience multiple mergers during
their lifetime. If every galaxy with a bulge hosts a SMBH in its center, and a
local galaxy has been made up by multiple mergers, then a black hole binary is
a natural evolutionary stage. The evolution of the supermassive black hole
population clearly has to be investigated taking into account both the
cosmological framework and the dynamical evolution of SMBHs and their hosts.
The seeds of SMBHs have to be looked for in the early Universe, as very
luminous quasars are detected up to redshift higher than z=6. These black holes
evolve then in a hierarchical fashion, following the merger hierarchy of their
host halos. Accretion of gas, traced by quasar activity, plays a fundamental
role in determining the two parameters defining a black hole: mass and spin. A
particularly intriguing epoch is the initial phase of SMBH growth. It is very
challenging to meet the observational constraints at z=6 if BHs are not fed at
very high rates in their infancy.Comment: Extended version of the invited paper to appear in the Proceedings of
the Conference "Relativistic Astrophysics and Cosmology - Einstein's Legacy
Perturbation Study of the Conductance through an Interacting Region Connected to Multi-Mode Leads
We study the effects of electron correlation on transport through an
interacting region connected to multi-mode leads based on the perturbation
expansion with respect to the inter-electron interaction. At zero temperature
the conductance defined in the Kubo formalism can be written in terms of a
single-particle Green's function at the Fermi energy, and it can be mapped onto
a transmission coefficient of the free quasiparticles described by an effective
Hamiltonian. We apply this formulation to a two-dimensional Hubbard model of
finite size connected to two noninteracting leads. We calculate the conductance
in the electron-hole symmetric case using the order self-energy. The
conductance shows several maximums in the dependence in some parameter
regions of , where () is the hopping matrix element in the
- (-) directions. This is caused by the resonance occurring in some of
the subbands, and is related with the dependence of the eigenvalues of the
effective Hamiltonian.Comment: 17 pages, 12 figures, to be published in J.Phys.Soc.Jpn. 71(2002)No.
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