Saudi-American Bilateral Relations: a Case Study of the Consequences of Interdependence on International Relations

This study examines the consequences of interdependence between Saudi Arabia and the United States from 1960 to 1978 as it relates to the concepts of cooperation and conflict. Research on interdependence focuses primarily on relations among Western countries and on whether interdependence is increasing or decreasing between them. It has rarely addressed relations between countries with different levels of economic development or the consequence of interdependence for international relations in terms of conflict and cooperation. Specifically, this study examines the following question: Does the level of interdependence between Saudi Arabia and the United States have any affect on the level of bilateral conflict and cooperation between the two countries? The hypotheses are tested using regression analysis. The primary conclusion is that increases in bilateral interdependence between Saudi Arabia and the United States from 1960 to 1978 produced increased cooperation as well as conflict

Phenotypic and transcriptomic characterization of canine myeloid-derived suppressor cells

Myeloid-derived suppressor cells (MDSCs) are key players in immune evasion, tumor progression and metastasis. MDSCs accumulate under various pathological states and fall into two functionally and phenotypically distinct subsets that have been identified in humans and mice: polymorphonuclear (PMN)-MDSCs and monocytic (M)-MDSCs. As dogs are an excellent model for human tumor development and progression, we set out to identify PMN-MDSCs and M-MDSCs in clinical canine oncology patients. Canine hypodense MHC class II-CD5-CD21-CD11b+ cells can be subdivided into polymorphonuclear (CADO48A+CD14-) and monocytic (CADO48A-CD14+) MDSC subsets. The transcriptomic signatures of PMN-MDSCs and M-MDSCs are distinct, and moreover reveal a statistically significant similarity between canine and previously published human PMN-MDSC gene expression patterns. As in humans, peripheral blood frequencies of canine PMN-MDSCs and M-MDSCs are significantly higher in dogs with cancer compared to healthy control dogs (PMN-MDSCs: p < 0.001; M-MDSCs: p < 0.01). By leveraging the power of evolution, we also identified additional conserved genes in PMN-MDSCs of multiple species that may play a role in MDSC function. Our findings therefore validate the dog as a model for studying MDSCs in the context of cancer

Timing of maternal death: Levels, trends, and ecological correlates using sibling data from 34 sub-Saharan African countries.

Millennium Development Goal 5 has not been universally achieved, particularly in sub-Saharan Africa. Understanding whether maternal deaths occur during pregnancy, childbirth, or puerperium is important to effectively plan maternal health programs and allocate resources. Our main research objectives are to (1) describe the proportions and rates of mortality for the antepartum, intrapartum, and postpartum periods; (2) document how these trends vary by sub-region; and (3) investigate ecological correlations between these rates and maternal care interventions. We used data from the Demographic and Health Survey program, which comprises 84 surveys from 34 sub-Saharan African countries conducted between 1990 and 2014. We calculated age-standardized maternal mortality rates and time-specific maternal mortality rates and proportions, and we assessed correlations with maternal care coverage. We found high levels of maternal mortality in all three periods. Time-specific maternal mortality rates varied by country and region, with some showing an orderly decline in all three periods and others exhibiting alarming increases in antepartum and postpartum mortality. Ecological analysis showed that antenatal care coverage was significantly associated with low antepartum mortality, whereas the presence of a skilled attendant at childbirth was significantly associated with low postpartum mortality. In sub-Saharan Africa, maternal deaths occur at high rates in all three risk periods, and vary substantially by country and region. The provision of maternal care is a predictor of time-specific maternal mortality. These results confirm the need for country-specific interventions during the continuum of care to achieve the global commitment to eliminating preventable maternal mortality

Antenatal and childbirth care by sub-Saharan African region.

<p>Antenatal and childbirth care by sub-Saharan African region.</p

Timing of maternal death (antepartum, intrapartum and postpartum) by sub-Saharan African region.

<p>Timing of maternal death (antepartum, intrapartum and postpartum) by sub-Saharan African region.</p