459 research outputs found
Slow equivariant lump dynamics on the two sphere
The low-energy, rotationally equivariant dynamics of n CP^1 lumps on S^2 is
studied within the approximation of geodesic motion in the moduli space of
static solutions. The volume and curvature properties of this moduli space are
computed. By lifting the geodesic flow to the completion of an n-fold cover of
the moduli space, a good understanding of nearly singular lump dynamics within
this approximation is obtained.Comment: 12 pages, 3 figure
Emissions budgets for shipping in a 2°C and a 4°C global warming scenario, and implications for operational efficiency
To achieve the widely accepted goal of keeping global temperature rise below 2°C above pre-industrial levels, greenhouse gas emissions must reduce drastically over the coming decades. Under this premise, the assumption that the shipping industry realises the same proportionate CO2 emission reductions as all other sectors on average has strong implications. This paper begins by considering an appropriate global CO2 emissions budget associated with a temperature rise of 2°C. Next, a range of future demand scenarios for international transport shipping are presented. Meeting the demand in any of the scenarios, while remaining within the emissions budget, requires stringent increases in overall operational efficiency. Different emissions and efficiency trajectories â with efficiency expressed in terms of the Energy Efficiency Operational Indicator (EEOI) â in line with the 2°C target are analysed. The potential short and long term levers of operational efficiency are explored
Magnetic bubble refraction and quasibreathers in inhomogeneous antiferromagnets
The dynamics of magnetic bubble solitons in a two-dimensional isotropic
antiferromagnetic spin lattice is studied, in the case where the exchange
integral J(x,y) is position dependent. In the near continuum regime, this
system is described by the relativistic O(3) sigma model on a spacetime with a
spatially inhomogeneous metric, determined by J. The geodesic approximation is
used to describe low energy soliton dynamics in this system: n-soliton motion
is approximated by geodesic motion in the moduli space of static n-solitons,
equipped with the L^2 metric. Explicit formulae for this metric for various
natural choices of J(x,y) are obtained. From these it is shown that single
soliton trajectories experience refraction, with 1/J analogous to the
refractive index, and that this refraction effect allows the construction of
simple bubble lenses and bubble guides. The case where J has a disk
inhomogeneity (taking the value J_1 outside a disk, and J_2<J_1 inside) is
considered in detail. It is argued that, for sufficiently large J_1/J_2 this
type of antiferromagnet supports approximate quasibreathers: two or more
coincident bubbles confined within the disk which spin internally while their
shape undergoes periodic oscillations with a generically incommensurate period.Comment: Conference proceedings paper for talk given at Nonlinear Physics
Theory and Experiment IV, Gallipoli, Italy, June 200
Quantum lump dynamics on the two-sphere
It is well known that the low-energy classical dynamics of solitons of
Bogomol'nyi type is well approximated by geodesic motion in M_n, the moduli
space of static n-solitons. There is an obvious quantization of this dynamics
wherein the wavefunction evolves according to the Hamiltonian H_0 equal to
(half) the Laplacian on M_n. Born-Oppenheimer reduction of analogous mechanical
systems suggests, however, that this simple Hamiltonian should receive
corrections including k, the scalar curvature of M_n, and C, the n-soliton
Casimir energy, which are usually difficult to compute, and whose effect on the
energy spectrum is unknown. This paper analyzes the spectra of H_0 and two
corrections to it suggested by work of Moss and Shiiki, namely H_1=H_0+k/4 and
H_2=H_1+C, in the simple but nontrivial case of a single CP^1 lump moving on
the two-sphere. Here M_1=TSO(3), a noncompact kaehler 6-manifold invariant
under an SO(3)xSO(3) action, whose geometry is well understood. The symmetry
gives rise to two conserved angular momenta, spin and isospin. A hidden
isometry of M_1 is found which implies that all three energy spectra are
symmetric under spin-isospin interchange. The Casimir energy is found exactly
on the zero section of TSO(3), and approximated numerically on the rest of M_1.
The lowest 19 eigenvalues of H_i are found for i=0,1,2, and their spin-isospin
and parity compared. The curvature corrections in H_1 lead to a qualitatively
unchanged low-level spectrum while the Casimir energy in H_2 leads to
significant changes. The scaling behaviour of the spectra under changes in the
radii of the domain and target spheres is analyzed, and it is found that the
disparity between the spectra of H_1 and H_2 is reduced when the target sphere
is made smaller.Comment: 35 pages, 3 figure
CO2 abatement goals for international shipping
The Paris Agreement, which entered into force in 2016, sets the ambitious climate change mitigation goal of limiting the global temperature increase to below 2°C and ideally 1.5°C. This puts a severe constraint on the remaining global GHG emissions budget. While international shipping is also a contributor to anthropogenic GHG emissions, and CO2 in particular, it is not included in the Paris Agreement. This article discusses how a share of a global CO2 budget over the twenty-first century could be apportioned to international shipping, and, using a range of future trade scenarios, explores the requisite cuts to the CO2 intensity of shipping. The results demonstrate that, under a wide range of assumptions, existing short-term levers of efficiency must be urgently exploited to achieve mitigation commensurate with that required from the rest of the economy, with virtually full decarbonization of international shipping required as early as before mid-century
El territoi d'Emporion i les seves dades paleoambientals
Se aportan nuevos datos que provienen de un sondeo efectuado en las marismas del ArnpurdĂĄn (Girona). En resumen, la Ă©poca ibĂ©rica se caracteriza por un aprovechamiento sostenibie de los recursos naturales y ia romana por potenciar mĂĄs ei cultivo de/ oiivo que el de los cereales; ia triada cereai/oiivo/viña es mĂĄs tĂpica de los perĂodos medievales y posteriores. Predomina en ia zona un paisaje de ralos aicornocaies y encinares mixtos, con pocos pinos, determinado por un clima mediterrĂĄneo templado con escasas precipitaciones.New data are presented frorn a core takan frorn the wetiands of the Emporda (Girona). in summary, the iberian period is characterised by sustainable use of natural resources, whiie the Roman period shows more intensive cuitivation of olives than of cereals; the triad cereal/ olive/ vine is typicai of the medieval and iater periods. The predorninant landscape NI the area supported cork oak and other mixed species, with few pines, typical of a temperate Mediterranean ciirnate with iittle precipitation
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The Emotional Word-Emotional Face Stroop task in the ABCD study: Psychometric validation and associations with measures of cognition and psychopathology
Characterizing the interactions among attention, cognitive control, and emotion during adolescence may provide important insights into why this critical developmental period coincides with a dramatic increase in risk for psychopathology. However, it has proven challenging to develop a single neurobehavioral task that simultaneously engages and differentially measures these diverse domains. In the current study, we describe properties of performance on the Emotional Word-Emotional Face Stroop (EWEFS) task in the Adolescent Brain Cognitive Development (ABCD) Study, a task that allows researchers to concurrently measure processing speed/attentional vigilance (i.e., performance on congruent trials), inhibitory control (i.e., Stroop interference effect), and emotional information processing (i.e., difference in performance on trials with happy as compared to angry distracting faces). We first demonstrate that the task manipulations worked as designed and that Stroop performance is associated with multiple cognitive constructs derived from different measures at a prior time point. We then show that Stroop metrics tapping these three domains are preferentially associated with aspects of externalizing psychopathology and inattention. These results highlight the potential of the EWEFS task to help elucidate the longitudinal dynamics of attention, inhibitory control, and emotion across adolescent development, dynamics which may be altered by level of psychopathology
SLAP Is a Negative Regulator of FcΔRI Receptor-Mediated Signaling and Allergic Response
Binding of antigen to IgE-high affinity FcΔRI complexes on mast cells and basophils results in the release of preformed mediators such as histamine and de novo synthesis of cytokines causing allergic reactions. Src-like adapter protein (SLAP) functions co-operatively with c-Cbl to negatively regulate signaling downstream of the T cell receptor, B cell receptor, and receptor tyrosine kinases (RTK). Here, we investigated the role of SLAP in FcΔRI-mediated mast cell signaling, using bone marrow derived mast cells (BMMCs) from SLAP knock out (SLAP KO) mice. Mature SLAP-KO BMMCs displayed significantly enhanced antigen induced degranulation and synthesis of IL-6, TNFα, and MCP-1 compared to wild type (WT) BMMCs. In addition, SLAP KO mice displayed an enhanced passive cutaneous anaphylaxis response. In agreement with a negative regulatory role, SLAP KO BMMCs showed enhanced FcΔRI-mediated signaling to downstream effector kinases, Syk, Erk, and Akt. Recombinant GST-SLAP protein binds to the FcΔRIÎČ chain and to the Cbl-b in mast cell lysates, suggesting a role in FcΔRI down regulation. In addition, the ubiquitination of FcΔRIÎł chain and antigen mediated down regulation of FcΔRI is impaired in SLAP KO BMMCs compared to the wild type. In line with these findings, stimulation of peripheral blood human basophils with FcΔRIα antibody, or a clinically relevant allergen, resulted in increased SLAP expression. Together, these results indicate that SLAP is a dynamic regulator of IgE-FcΔRI signaling, limiting allergic responses
Kinetics of plasma cellâfree DNA and creatine kinase in a canine model of tissue injury
Background:
Cellâfree DNA (cfDNA) comprises short, doubleâstranded circulating DNA sequences released from damaged cells. In people, cfDNA concentrations correlate well with disease severity and tissue damage. No reports are available regarding cfDNA kinetics in dogs.
Objectives/Hypothesis:
Cellâfree DNA will have a short biological halfâlife and would be able to stratify mild, moderate, and severe tissue injury. Our study aims were to determine the kinetics and biological halfâlife of cfDNA and to contrast them with those of creatine kinase (CK).
Animals:
Three groups of 10 dogs undergoing open ovariohysterectomy, surgery for cranial cruciate ligament rupture (CCLR), or hemilaminectomy.
Methods:
Plasma for cfDNA and CK analysis was collected at admission, at induction of anesthesia, postsurgery (time 0) and at 6, 12, 24, 36, 48, 60, and 72 hours after surgery.
Results:
The biological halfâlife of plasma cfDNA and CK were 5.64 hours (95% confidence interval [CI 95], 4.36â7.98 hours) and 28.7 hours (CI95, 25.3â33.3 hours), respectively. In the hemilaminectomy group, cfDNA concentrations differed significantly from admission at 6â12 hours after surgery. Creatine kinase activity differed among the surgical groups and reached a peak 6 hours after surgery. In the ovariohysterectomy and CCLR groups, plasma CK activity 72 hours after surgery did not differ from admission activity of the ovariohysterectomy group. In contrast, in the hemilaminectomy group, plasma CK activity after 72 hours did not return to the ovariohysterectomy group admission activity.
Conclusions and Clinical Importance:
Plasma CK activity has a longer biological halfâlife than previously thought. In contrast to plasma CK activity, cfDNA has a short halfâlife and could be a useful marker for peracute severe tissue injury
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