Treatment of an aneurysmal bone cyst in a young dog: A case report

Background: An aneurysmal bone cyst (ABC) is a rare benign lytic lesion affecting the medullary canal of long bones. It has been widely reported in human medicine, but rarely described in domestic animals. Objective: To report the surgical treatment and long term follow-up of a dog affected by ABC. Methods: An 8-month-old, intact female Weimaraner was presented with lameness affecting the left front limb and progressive swelling of the mid-distal radius. Survey radiographs revealed a mid-distal diaphyseal radial lesion. Fine needle aspirates, biopsy, CT scan and histopathology results supported the diagnosis of ABC. Treatment consisted of partial corticotomy of the affected radius, filling of the cystic cavity with demineralised bone matrix and autologous bone graft and stabilisation using lag screws and a neutralisation plate. Results: The long-term follow-up, at 36 post-operative months, showed no recurrence of the cyst and bone modelling. Comparing preoperative radiographs with those at 36 months, bone modelling reduced the radial area by 23.3% in the craniocaudal radiographic view and 30% in the mediolateral projection. Conclusions: This treatment was sucessful in the case here described, with a 3 years follow-up

Incisivo lateral superior con dos raíces y dos conductos. Caso Clínico.

Las anomalías en la morfología del incisivo lateral superior son de muy baja frecuencia. Las anomalías de desarrollo radicular pueden presentarse como alteraciones tanto en el número de conductos, como en el número de raíces, así como en ambas regiones a la vez. En el presente trabajo, se reporta el caso de un paciente que se presenta a la consulta con malestar en el incisivo lateral superior izquierdo. En la radiografía preoperatoria se detectó la presencia de dos conductos y dos raíces, sin anomalía morfológica de su corona clínica, con requerimiento de tratamiento endodóntico. Concluimos que una correcta interpretación de las imágenes radiográficas preoperatorias es esencial, para poder detectar estas variantes y tomar las consideraciones necesarias para el adecuado tratamiento endodóntico.Fil: Martinez, P.. Universidad de Buenos Aires. Facultad de Odontología; Argentina;Fil: Boldo, M.. Universidad de Buenos Aires. Facultad de Odontología; Argentina;Fil: Corominola, P.. Universidad de Buenos Aires. Facultad de Odontología; Argentina;Fil: Sierra, L.. Universidad de Buenos Aires. Facultad de Odontología; Argentina;Fil: Lenarduzzi, A.. Universidad de Buenos Aires. Facultad de Odontología; Argentina;Fil: Fernández Solari, Jose Javier. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Fisiología; Argentina;Fil: Rodriguez, P.. Universidad de Buenos Aires. Facultad de Odontología; Argentina

A preliminary investigation of developer profiles based on their activities and code quality: who does what?

Developers work on different tasks in different conditions based on individual technical skills and personal habits. Identifying developer groups by mining their repositories is key for various tasks ranging from understanding developers types in open source projects, to help project managers concerned with the team allocation and coordination of human resources in companies. We aimed at identifying distinct groups of developer profiles based on well defined characteristics and at characterizing the most common quality issue types introduced by each profile in their code. We considered 77,932 commits of 33 open source Java projects, clustering their 2460 developers using dimensionality reduction techniques and applying the k-means algorithm. We identified five profiles among 2460 developers based on project experience, developer productivity and the common quality issues they introduce in the code. Results can be used by developer teams to detect and cope with harmful practices, in order to be more efficient by reducing the number of bugs they produce, looking for adequate training options, and balancing their teams.The research presented in this paper has been developed in the context of the TAED2 course at the GCED@FIB. This work has been partially funded by the “Beatriz Galindo” Spanish Program BEAGAL18/00064 and by the DOGO4ML Spanish research project (ref. PID2020-117191RB-I00)Peer ReviewedPostprint (author's final draft

Usher syndrome: An effective sequencing approach to establish a genetic and clinical diagnosis

12noUsher syndrome is an autosomal recessive disorder characterized by retinitis pigmentosa, sensorineural hearing loss and, in some cases, vestibular dysfunction. The disorder is clinically and genetically heterogeneous and, to date, mutations in 11 genes have been described. This finding makes difficult to get a precise molecular diagnosis and offer patients accurate genetic counselling. To overcome this problem and to increase our knowledge of the molecular basis of Usher syndrome, we designed a targeted resequencing custom panel. In a first validation step a series of 16 Italian patients with known molecular diagnosis were analysed and 31 out of 32 alleles were detected (97% of accuracy). After this step, 31 patients without a molecular diagnosis were enrolled in the study. Three out of them with an uncertain Usher diagnosis were excluded. One causative allele was detected in 24 out 28 patients (86%) while the presence of both causative alleles characterized 19 patients out 28 (68%). Sixteen novel and 27 known alleles were found in the following genes: USH2A (50%), MYO7A (7%), CDH23 (11%), PCDH15 (7%) and USH1G (2%). Overall, on the 44 patients the protocol was able to characterize 74 alleles out of 88 (84%). These results suggest that our panel is an effective approach for the genetic diagnosis of Usher syndrome leading to: 1) an accurate molecular diagnosis, 2) better genetic counselling, 3) more precise molecular epidemiology data fundamental for future interventional plans.partially_openembargoed_20160106Lenarduzzi, S.; Vozzi, D; Morgan, A.; Rubinato, E.; D'Eustacchio, A.; Osland, T.M.; Rossi, C.; Graziano, C.; Castorina, P.; Ambrosetti, U.; Morgutti, M.; Girotto, G.Lenarduzzi, Stefania; Vozzi, Diego; Morgan, Anna; Rubinato, Elisa; D'Eustacchio, A.; Osland, TERESA MARIA; Rossi, C.; Graziano, C.; Castorina, P.; Ambrosetti, U.; Morgutti, Marcello; Girotto, Giorgi

Caracterización hidrodinámica experimental de un tramo del Río Tercero (Ctalamochita) con fines hidroambientales

Fil: Lenarduzzi, Marcos. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Centro de Estudios y Tecnología del Agua; Argentina.Fil: García, Carlos M. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Centro de Estudios y Tecnología del Agua; Argentina.Fil: Herrero, Horacio. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Centro de Estudios y Tecnología del Agua; Argentina.Fil: Ragessi, Ivan Matias. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Centro de Estudios y Tecnología del Agua; Argentina.Fil: Hillman, Gerardo. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Centro de Estudios y Tecnología del Agua; Argentina.Fil: Cossavella, Ana María. Gobierno de la Provincia de Córdoba. Área Preservación y Control del Recurso de la Secretaria de Recursos Hídricos; Argentina.Fil: Cossavella, Ana María. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina.Fil: Nadal, Florencia. Instituto Nacional del Agua. Área de Limnología y Calidad de Agua; Argentina.El Río Tercero (Ctalamochita) está localizado en la Provincia de Córdoba, y es uno de los ríos más importantes en la región debido a su caudal relativo, por lo que es necesario garantizar la calidad de este recurso como fuente de agua potable para consumo de la población. En su primer tramo aguas abajo del sistema de embalses, en la ciudad de Río Tercero, se ubica un polo industrial, y por tal motivo es una zona crítica con potencial riesgo de contaminación. Así, es importante realizar un seguimiento del recurso con un enfoque integral, con el objetivo de detectar cambios tanto hidrodinámicos, como ambientales para elaborar un plan de acción a implementar en la cuenca. En este aspecto la Facultad de Ciencias Exactas, Físicas y Naturales de la Universidad Nacional de Córdoba (FCEFyN – UNC) realiza en forma periódica monitoreos de calidad de agua y aforos mediante métodos convencionales como por ejemplo aforo por vadeo con molinetes, pero la desventaja de esta técnica no es sólo la baja resolución espacial de los datos de velocidad, sino que debido a las elevadas velocidades del flujo en algunas secciones resulta difícil llevar a cabo el vadeo. Los Perfiladores de Corriente Acústica Doppler (ADCP), disponibles actualmente, permiten mejorar los muestreos obtenidos con técnicas convencionales logrando mayor resolución espacial y temporal de las velocidades del flujo, como así mayor precisión en el relevamiento de la morfología del cauce.Fil: Lenarduzzi, Marcos. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Centro de Estudios y Tecnología del Agua; Argentina.Fil: García, Carlos M. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Centro de Estudios y Tecnología del Agua; Argentina.Fil: Herrero, Horacio. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Centro de Estudios y Tecnología del Agua; Argentina.Fil: Ragessi, Ivan Matias. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Centro de Estudios y Tecnología del Agua; Argentina.Fil: Hillman, Gerardo. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Centro de Estudios y Tecnología del Agua; Argentina.Fil: Cossavella, Ana María. Gobierno de la Provincia de Córdoba. Área Preservación y Control del Recurso de la Secretaria de Recursos Hídricos; Argentina.Fil: Cossavella, Ana María. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina.Fil: Nadal, Florencia. Instituto Nacional del Agua. Área de Limnología y Calidad de Agua; Argentina.Ingeniería Civi

Development of a Versatile Laser Ultrasonic System and Application to On-Line Measurement for Process Control of Wall Thickness and Eccentrictiy of Steel Seamless Mechanical Tubing

Researchers at the Timken Company conceived a project to develop an on-line instrument for wall thickness measurement of steel seamless mechanical tubing based on laser ultrasonic technology. The instrument, which has been installed and tested at a piercing mill, provides data on tube eccentricity and concentricity. Such measurements permit fine-tuning of manufacturing processes to eliminate excess material in the tube wall and therefore provide a more precisely dimensioned product for their customers. The resulting process energy savings are substantial, as is lowered environmental burden. The expected savings are $85.8 million per year in seamless mechanical tube piercing alone. Applied across the industry, this measurement has a potential of reducing energy consumption by 6 x 10{sup 12} BTU per year, greenhouse gas emissions by 0.3 million metric tons carbon equivalent per year, and toxic waste by 0.255 million pounds per year. The principal technical contributors to the project were the Timken Company, Industrial Materials Institute (IMI, a contractor to Timken), and Oak Ridge National Laboratory (ORNL). Timken provided mill access as well as process and metallurgical understanding. Timken researchers had previously developed fundamental ultrasonic analysis methods on which this project is based. IMI developed and fabricated the laser ultrasonic generation and receiver systems. ORNL developed Bayesian and wavelet based real-time signal processing, spread-spectrum wireless communication, and explored feature extraction and pattern recognition methods. The resulting instrument has successfully measured production tubes at one of Timken's piercing mills. This report concentrates on ORNL's contribution through the CRADA mechanism. The three components of ORNL's contribution were met with mixed success. The real-time signal-processing task accomplished its goal of improvement in detecting time of flight information with a minimum of false data. The signal processing algorithm development resulted in a combination of processing steps that can be set to generate no spoofs from noise, while simultaneously missing fewer than 10% of good trials. The algorithm leads to a 95% probability that the estimate of time of flight is good to within 4 time bins or fewer for laser excitations above 30 mJ for the first two echoes of the signal. Receiver Operating Characteristic (ROC) curves for the algorithm indicate that the algorithm is very robust against errors for excitations above at 35 mJ and above, tolerable at 30 mJ and unacceptable below 30 mJ

Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk

The timing of puberty is a highly polygenic childhood trait that is epidemiologically associated with various adult diseases. Using 1000 Genomes Project-imputed genotype data in up to similar to 370,000 women, we identify 389 independent signals (P <5 x 10(-8)) for age at menarche, a milestone in female pubertal development. In Icelandic data, these signals explain similar to 7.4% of the population variance in age at menarche, corresponding to similar to 25% of the estimated heritability. We implicate similar to 250 genes via coding variation or associated expression, demonstrating significant enrichment in neural tissues. Rare variants near the imprinted genes MKRN3 and DLK1 were identified, exhibiting large effects when paternally inherited. Mendelian randomization analyses suggest causal inverse associations, independent of body mass index (BMI), between puberty timing and risks for breast and endometrial cancers in women and prostate cancer in men. In aggregate, our findings highlight the complexity of the genetic regulation of puberty timing and support causal links with cancer susceptibility