Nuclear Equation of State from Observations of Short Gamma-Ray Burst Remnants

The favoured progenitor model for short $\gamma$-ray bursts (SGRBs) is the merger of two neutron stars that triggers an explosion with a burst of collimated $\gamma$-rays. Following the initial prompt emission, some SGRBs exhibit a plateau phase in their $X$-ray light curves that indicates additional energy injection from a central engine, believed to be a rapidly rotating, highly magnetised neutron star. The collapse of this `protomagnetar' to a black hole is likely to be responsible for a steep decay in $X$-ray flux observed at the end of the plateau. In this letter, we show that these observations can be used to effectively constrain the equation of state of dense matter. In particular, we show that the known distribution of masses in binary neutron star systems, together with fits to the $X$-ray light curves, provide constraints that exclude the softest and stiffest plausible equations of state. We further illustrate how a future gravitational wave observation with Advanced LIGO/Virgo can place tight constraints on the equation of state, by adding into the picture a measurement of the chirp mass of the SGRB progenitor.Comment: accepted for publication in Phys. Rev.

The complement binding-like domains of the murine homing receptor facilitate lectin activity.

The leukocyte homing receptor (HR), the endothelial leukocyte adhesion molecule, and gmp140/platelet activation-dependent granule membrane protein are members of a family of adhesion molecules, termed the lectin cell adhesion molecules (LEC-CAMS) which are unified by a multi-domain structure containing a lectin motif, an epidermal growth factor-like (egf) motif, and variable numbers of a complement binding-like (CB) motif. Previous data have indicated a predominant role for the lectin motif in cell adhesion directed by the LEC-CAMS, although the egf-like domain of the HR may also play a potential role in cell binding. While the role(s) of the CB domains in the LEC-CAMS is currently not understood, they have been hypothesized to act as rigid spacers or stalks for lectin and perhaps, egf domain presentation. In this paper, we analyze the functional characteristics of murine HR-IgG chimeras containing the lectin, lectin plus egf, and lectin plus egf plus CB domains. The Mel 14 mAb, an adhesion blocking antibody which recognizes a conformational determinant in the N-terminus of the HR lectin domain, shows a significantly decreased affinity for a HR construct which lacks the CB motifs, consistent with the possibility that the CB domains are involved with lectin domain structure. In agreement with this conjecture, HR mutants lacking the CB domains show a profound decrease in lectin-specific interaction with the carbohydrate polyphosphomannan ester, suggesting that the changes in Mel 14 affinity for the lectin domain are reflected in lectin functionality. Various assays investigating the interactions between the HR deletion mutants and the peripheral lymph node high endothelium, including cell blocking, immunohistochemical staining, and radioactively labeled ligand binding, all showed that removal of the CB domains results in a lack of HR adhesive function. These results imply that the CB domains of the HR, and, by analogy, the other members of the LEC-CAM family, may play important structural roles involving induction of lectin domain conformation and resultant functionality

Are gravitational waves from giant magnetar flares observable?

Are giant flares in magnetars viable sources of gravitational radiation? Few theoretical studies have been concerned with this problem, with the small number using either highly idealized models or assuming a magnetic field orders of magnitude beyond what is supported by observations. We perform nonlinear general-relativistic magnetohydrodynamics simulations of large-scale hydromagnetic instabilities in magnetar models. We utilise these models to find gravitational wave emissions over a wide range of energies, from 10^40 to 10^47 erg. This allows us to derive a systematic relationship between the surface field strength and the gravitational wave strain, which we find to be highly nonlinear. In particular, for typical magnetar fields of a few times 10^15 G, we conclude that a direct observation of f-modes excited by global magnetic field reconfigurations is unlikely with present or near-future gravitational wave observatories, though we also discuss the possibility that modes in a low-frequency band up to 100 Hz could be sufficiently excited to be relevant for observation.Comment: 4 pages, 3 figures. Further information can be found at http://www.physik.uni-tuebingen.de/institute/astronomie-astrophysik/institut/theoretische-astrophysik/forschung.htm

Stability and Quasinormal Modes of Black holes in Tensor-Vector-Scalar theory: Scalar Field Perturbations

The imminent detection of gravitational waves will trigger precision tests of gravity through observations of quasinormal ringing of black holes. While General Relativity predicts just two polarizations of gravitational waves, the so-called plus and cross polarizations, numerous alternative theories of gravity predict up to six different polarizations which will potentially be observed in current and future generations of gravitational wave detectors. Bekenstein's Tensor-Vector-Scalar (TeVeS) theory and its generalization fall into one such class of theory that predict the full gamut of six polarizations of gravitational waves. In this paper we begin the study of quasinormal modes (QNMs) in TeVeS by studying perturbations of the scalar field in a spherically symmetric background. We show that, at least in the case where superluminal propagation of perturbations is not present, black holes are generically stable to this kind of perturbation. We also make a unique prediction that, as the limit of the various coupling parameters of the theory tend to zero, the QNM spectrum tends to $1/\sqrt{2}$ times the QNM spectrum induced by scalar perturbations of a Schwarzschild black hole in General Relativity due to the intrinsic presence of the background vector field. We further show that the QNM spectrum does not vary significantly from this value for small values of the theory's coupling parameters, however can vary by as much as a few percent for larger, but still physically relevant parameters.Comment: Published in Physical Review

Development of an algorithm for the diagnosis of otitis media

Background: The relative importance of signs and symptoms in the diagnosis of otitis media has not been adequately evaluated. This has led to a large degree of variation in the criteria used to diagnose otitis media, which has resulted in inconsistencies in clinical care and discrepant research findings. Methods: A group of experienced otoscopists examined children presenting for primary care. We investigated the signs and symptoms that these otoscopists used to distinguish acute otitis media (AOM), otitis media with effusion (OME), and no effusion. We used recursive partitioning to develop a diagnostic algorithm. To assess the algorithm, we validated it in an independent dataset. Results: Bulging of the tympanic membrane (TM) was the main finding that otoscopists used to discriminate AOM from OME; information regarding the presence or absence of other signs and symptoms added little to the diagnostic process. Overall, 92% of children with AOM had a bulging TM compared with 0% of children with OME. Opacification and/or an air-fluid level was the main finding that the otoscopists used to discriminate OME from no effusion; 97% of children diagnosed with OME had an opaque TM compared with 5% of children diagnosed with no effusion. An algorithm that used bulging and opacification of the TM correctly classified 99% of ears in an independent dataset. Conclusions: Bulging of the TM was the finding that best discriminated AOM from OME. The algorithm developed here may prove to be useful in clinical care, research, and education concerning otitis media. Copyright © 2012 by Academic Pediatric Association

Air Quality Monitoring in the Southeast Community in the City of Newport News, VA

Purpose: The objective of this study was to assess air quality in the Southeast Community of Newport News, VA by monitoring air pollutants, including PM2.5, PM10, VOCs, NO2, and SO2. Currently, there is a lack of community specified air quality data in Newport News despite observed environmental degradation and public health problems. Methods: Three air sampling sites were located within residential areas of the Southeast Community, while four industrial air sampling sites were chosen based on proximity to potential pollution sources, including traffic emissions, the coal pier, and industrial activities. All of the industrial sites were located on the boundaries of the community. Each site was continuously monitored for eight hours per day and was sampled at least twice for data accuracy. A GRIMM PM monitor was used to measure PM2.5 and PM10 and a MultiRae PRO (model PGM-6248) was used to continuously quantify VOCs, NO2, and SO2. Results: While average PM2.5 and PM10 from all sample sites were within the acceptable range of EPA air quality criteria, averaged VOCs in the industrial and highway areas were higher than those in the community. Conclusion: The findings of this research suggest a need for long-term monitoring air quality with a series of air pollutants in the community

Pleiotropy of FRIGIDA enhances the potential for multivariate adaptation.

An evolutionary response to selection requires genetic variation; however, even if it exists, then the genetic details of the variation can constrain adaptation. In the simplest case, unlinked loci and uncorrelated phenotypes respond directly to multivariate selection and permit unrestricted paths to adaptive peaks. By contrast, 'antagonistic' pleiotropic loci may constrain adaptation by affecting variation of many traits and limiting the direction of trait correlations to vectors that are not favoured by selection. However, certain pleiotropic configurations may improve the conditions for adaptive evolution. Here, we present evidence that the Arabidopsis thaliana gene FRI (FRIGIDA) exhibits 'adaptive' pleiotropy, producing trait correlations along an axis that results in two adaptive strategies. Derived, low expression FRI alleles confer a 'drought escape' strategy owing to fast growth, low water use efficiency and early flowering. By contrast, a dehydration avoidance strategy is conferred by the ancestral phenotype of late flowering, slow growth and efficient water use during photosynthesis. The dehydration avoidant phenotype was recovered when genotypes with null FRI alleles were transformed with functional alleles. Our findings indicate that the well-documented effects of FRI on phenology result from differences in physiology, not only a simple developmental switch