6,343 research outputs found
Transition amplitude, partition function and the role of physical degrees of freedom in gauge theories
This work explores the quantum dynamics of the interaction between scalar
(matter) and vectorial (intermediate) particles and studies their thermodynamic
equilibrium in the grand-canonical ensemble. The aim of the article is to
clarify the connection between the physical degrees of freedom of a theory in
both the quantization process and the description of the thermodynamic
equilibrium, in which we see an intimate connection between physical degrees of
freedom, Gibbs free energy and the equipartition theorem. We have split the
work into two sections. First, we analyze the quantum interaction in the
context of the generalized scalar Duffin-Kemmer-Petiau quantum electrodynamics
(GSDKP) by using the functional formalism. We build the Hamiltonian structure
following the Dirac methodology, apply the Faddeev-Senjanovic procedure to
obtain the transition amplitude in the generalized Coulomb gauge and, finally,
use the Faddeev-Popov-DeWitt method to write the amplitude in covariant form in
the no-mixing gauge. Subsequently, we exclusively use the Matsubara-Fradkin
(MF) formalism in order to describe fields in thermodynamical equilibrium. The
corresponding equations in thermodynamic equilibrium for the scalar, vectorial
and ghost sectors are explicitly constructed from which the extraction of the
partition function is straightforward. It is in the construction of the
vectorial sector that the emergence and importance of the ghost fields are
revealed: they eliminate the extra non-physical degrees of freedom of the
vectorial sector thus maintaining the physical degrees of freedom
Site-selective protein modification via disulfide rebridging for fast tetrazine/trans-cyclooctene bioconjugation
An inverse electron demand Diels–Alder reaction between tetrazine and trans-cyclooctene (TCO) holds great promise for protein modification and manipulation. Herein, we report the design and synthesis of a tetrazine-based disulfide rebridging reagent, which allows the site-selective installation of a tetrazine group into disulfide-containing peptides and proteins such as the hormone somatostatin (SST) and the antigen binding fragment (Fab) of human immunoglobulin G (IgG). The fast and efficient conjugation of the tetrazine modified proteins with three different TCO-containing substrates to form a set of bioconjugates in a site-selective manner was successfully demonstrated for the first time. Homogeneous, well-defined bioconjugates were obtained underlining the great potential of our method for fast bioconjugation in emerging protein therapeutics. The formed bioconjugates were stable against glutathione and in serum, and they maintained their secondary structure. With this work, we broaden the scope of tetrazine chemistry for site-selective protein modification to prepare well-defined SST and Fab conjugates with preserved structures and good stability under biologically relevant conditions
On the Integrability and Chaos of an N=2 Maxwell-Chern-Simons-Higgs Mechanical Model
We apply different integrability analysis procedures to a reduced (spatially
homogeneous) mechanical system derived from an off-shell non-minimally coupled
N=2 Maxwell-Chern-Simons-Higgs model that presents BPS topological vortex
excitations, numerically obtained with an ansatz adopted in a special -
critical coupling - parametric regime. As a counterpart of the regularity
associated to the static soliton-like solution, we investigate the possibility
of chaotic dynamics in the evolution of the spatially homogeneous reduced
system, descendant from the full N=2 model under consideration. The originally
rich content of symmetries and interactions, N=2 susy and non-minimal coupling,
singles out the proposed model as an interesting framework for the
investigation of the role played by (super-)symmetries and parametric domains
in the triggering/control of chaotic behavior in gauge systems.
After writing down effective Lagrangian and Hamiltonian functions, and
establishing the corresponding canonical Hamilton equations, we apply global
integrability Noether point symmetries and Painleveproperty criteria to both
the general and the critical coupling regimes. As a non-integrable character is
detected by the pair of analytical criteria applied, we perform suitable
numerical simulations, as we seek for chaotic patterns in the system evolution.
Finally, we present some Comments on the results and perspectives for further
investigations and forthcoming communications.Comment: 18 pages, 5 figure
N=2-Maxwell-Chern-Simons model with anomalous magnetic moment coupling via dimensional reduction
An N=1--supersymmetric version of the Cremmer-Scherk-Kalb-Ramond model with
non-minimal coupling to matter is built up both in terms of superfields and in
a component-field formalism. By adopting a dimensional reduction procedure, the
N=2--D=3 counterpart of the model comes out, with two main features: a genuine
(diagonal) Chern-Simons term and an anomalous magnetic moment coupling between
matter and the gauge potential.Comment: 15 pages, Latex; one reference corrected; To be published in the Int.
J. Mod. Phys.
Self-dual vortices in a Maxwell-Chern-Simons model with non-minimal coupling
We find self-dual vortex solutions in a Maxwell-Chern-Simons model with
anomalous magnetic moment. From a recently developed N=2-supersymmetric
extension, we obtain the proper Bogomol'nyi equations together with a Higgs
potential allowing both topological and non-topological phases in the theory.Comment: 12 pages, 9 figures, 2 tables; some typos corrected, one reference
updated. To be published in the Int. J. Mod. Phys. A (1999
Resolved Young Binary Systems And Their Disks
We have conducted a survey of young single and multiple systems in the Taurus–Auriga star-forming region with the Atacama Large Millimeter Array (ALMA), substantially improving both the spatial resolution and sensitivity with which individual protoplanetary disks in these systems have been observed. These ALMA observations can resolve binary separations as small as 25–30 au and have an average 3σ detection level of 0.35 mJy, equivalent to a disk mass of 4 × 10−5 M ⊙ for an M3 star. Our sample was constructed from stars that have an infrared excess and/or signs of accretion and have been classified as Class II. For the binary and higher-order multiple systems observed, we detect λ = 1.3 mm continuum emission from one or more stars in all of our target systems. Combined with previous surveys of Taurus, our 21 new detections increase the fraction of millimeter-detected disks to over 75% in all categories of stars (singles, primaries, and companions) earlier than spectral type M6 in the Class II sample. Given the wealth of other information available for these stars, this has allowed us to study the impact of multiplicity with a much larger sample. While millimeter flux and disk mass are related to stellar mass as seen in previous studies, we find that both primary and secondary stars in binary systems with separations of 30–4200 au have lower values of millimeter flux as a function of stellar mass than single stars. We also find that for these systems, the circumstellar disk around the primary star does not dominate the total disk mass in the system and contains on average 62% of the total mass
Physiological Effects of Five Different Marine Natural Organic Matters (NOMs) and Three Different Metals (Cu, Pb, Zn) on Early Life Stages of the Blue Mussel (Mytilus galloprovincialis)
Metals are present in aquatic environments as a result of natural and anthropogenic inputs, and may induce toxicity to organisms. One of the main factors that influence this toxicity in fresh water is natural organic matter (NOM) but all NOMs are not the same in this regard. In sea water, possible protection by marine NOMs is not well understood. Thus, our study isolated marine NOMs by solid-phase extraction from five different sites and characterized them by excitation-emission fluorescence analysis—one inshore (terrigenous origin), two offshore (autochthonous origin), and two intermediate in composition (indicative of a mixed origin). The physiological effects of these five NOMS alone (at 8 mg/L), of three metals alone (copper, lead and zinc at 6 µg Cu/L, 20 µg Pb/L, and 25 µg Zn/L respectively), and of each metal in combination with each NOM, were evaluated in 48-h exposures of mussel larvae. Endpoints were whole body Ca2++Mg2+-ATPase activity, carbonic anhydrase activity and lipid peroxidation. By themselves, NOMs increased lipid peroxidation, Ca2++Mg2+-ATPase, and/or carbonic anhydrase activities (significant in seven of 15 NOM-endpoint combinations), whereas metals by themselves did not affect the first two endpoints, but Cu and Pb increased carbonic anhydrase activities. In combination, the effects of NOMs predominated, with the metal exerting no additional effect in 33 out of 45 combinations. While NOM effects varied amongst different isolates, there was no clear pattern with respect to optical or chemical properties. When NOMs were treated as a single source by data averaging, NOM had no effect on Ca2++Mg2+-ATPase activity but markedly stimulated carbonic anhydrase activity and lipid peroxidation, and there were no additional effects of any metal. Our results indicate that marine NOMs may have direct effects on this model marine organism, as well as protective effects against metal toxicity, and the quality of marine NOMs may be an important factor in these actions
Ordenha higiênica de leite de cabra.
Passos para ordenha higiênica; Limpeza da sala de ordenha e dos vasilhames.bitstream/item/132809/1/ID-38686.pd
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