Geothermal electricity generation and desalination: an integrated process design to conserve latent heat with operational improvements

A new process combination is proposed to link geothermal electricity generation with desalination. The concept involves maximizing the utilization of harvested latent heat by passing the turbine exhaust steam into a multiple effect distillation system and then into an adsorption desalination system. Processes are fully integrated to produce electricity, desalted water for consumer consumption, and make-up water for the geothermal extraction system. Further improvements in operational efficiency are achieved by adding a seawater reverse osmosis system to the site to utilize some of the generated electricity and using on-site aquifer storage and recovery to maximize water production with tailoring of seasonal capacity requirements and to meet facility maintenance requirements. The concept proposed conserves geothermally harvested latent heat and maximizes the economics of geothermal energy development. Development of a fully renewable energy electric generation-desalination-aquifer storage campus is introduced within the framework of geothermal energy development

Floquet stroboscopic divisibility in non-Markovian dynamics

We provide a general discussion of the Liouvillian spectrum for a system coupled to a non-Markovian bath using Floquet theory. This approach is suitable when the system is described by a time-convolutionless master equation with time-periodic rates. Surprisingly, the periodic nature of rates allow us to have a stroboscopic divisible dynamical map at discrete times, which we refer to as Floquet stroboscopic divisibility. We illustrate the general theory for a Schr\"odinger cat which is roaming inside a non-Markovian bath, and demonstrate the appearance of stroboscopic revival of the cat at later time after its death. Our theory may have profound implications in entropy production in non-equilibrium systems.Comment: We changed the title and explained in more detail the definition of non-Markovian dynamics used in the manuscrip

Effect of age on the prognostic value of left ventricular function in patients with acute coronary syndrome:a prospective registry study

Objective: This study aims to study the prognostic impact of LV function on mortality and examine the effect of age on the prognostic value of left ventricular function.  Methods: We examined the Myocardial Ischaemia National Audit Project (MINAP) registry (2006-2010) data with a mean follow up of 2.1 years. LV function was categorized into good (ejection fraction (EF) ≥50%), moderate (EF 30-49%) and poor (EF <30%) categories. Cox-proportional hazards models were constructed to examine the prognostic significance of LV function in different age groups (<65, 65-74, 75-84 and ≥85 years) on all-cause mortality adjusting for baseline variables.  Results: Of 424,848 patients, LV function data available for 123,609. Multiple imputations were used to impute missing values of LV function and the final sample for analyses were drawn from 414,305. After controlling for confounders, 339,887 participants were included in the regression models. For any age group, mortality was higher with worsening degree of LV impairment. Increased age reduced the adverse prognosis associated with reduced LV function (hazard ratios (HRs) of death comparing poor LV function to good LV function were 2.11 95%CI 1.88-2.37 for age <65 years and 1.28 95%CI 1.20-1.36 for age ≥85 years. Older patients had a high mortality risk even in those with good LV function. HRs of mortality for ≥85 compared to <65 years (HR=1.00) within good, moderate and poor ejection fractions groups were 5.89, 4.86 and 3.43, respectively.  Conclusions: In patients with ACS, clinicians should interpret the prognostic value of LV function taking into account patient’s age

Cost effectiveness and resource allocation of Plasmodium falciparum malaria control in Myanmar: a modelling analysis of bed nets and community health workers.

BACKGROUND: Funding for malaria control and elimination in Myanmar has increased markedly in recent years. While there are various malaria control tools currently available, two interventions receive the majority of malaria control funding in Myanmar: (1) insecticide-treated bed nets and (2) early diagnosis and treatment through malaria community health workers. This study aims to provide practical recommendations on how to maximize impact from investment in these interventions. METHODS: A simple decision tree is used to model intervention costs and effects in terms of years of life lost. The evaluation is from the perspective of the service provider and costs and effects are calculated in line with standard methodology. Sensitivity and scenario analysis are undertaken to identify key drivers of cost effectiveness. Standard cost effectiveness analysis is then extended via a spatially explicit resource allocation model. FINDINGS: Community health workers have the potential for high impact on malaria, particularly where there are few alternatives to access malaria treatment, but are relatively costly. Insecticide-treated bed nets are comparatively inexpensive and modestly effective in Myanmar, representing a low risk but modest return intervention. Unlike some healthcare interventions, bed nets and community health workers are not mutually exclusive nor are they necessarily at their most efficient when universally applied. Modelled resource allocation scenarios highlight that in this case there is no "one size fits all" cost effectiveness result. Health gains will be maximized by effective targeting of both interventions

A non-contact capacitance type level transducer for liquid characterization

The liquid properties such as buoyancy, pressure at a depth, relative electrical permittivity, electrical conductivity, thermal conductivity, absorption of radiation, liquid surface reflection of sound or light waves, are used to design the different types of liquid level transducers for liquid level measurement in any process industry. The contact-type level-sensing transducers have the disadvantage that their characteristic properties may change due to physical or chemical reaction between the liquid and the probing material, and hence may affect accuracy besides their life time. The non-contact-type level-sensing probes may have longer life period, but they are comparatively costly and require various environmental and experimental precautionary measures when being used. In this paper, a low-cost non-contact capacitance type liquid level measuring technique has been designed and used for liquid identification objectives. The results obtained are very much consistent with the theoretical derivations

Capacitive transducer circuits for liquid level measurement

This work is making use of the capacitive element that is made of two electrodes - a column of liquid the level of which is to be measured, and a metallic tube that is pulled and fitted over a PVC tube of accordingly smaller dimensions. Both of the electrodes are provided with contact terminals for easy connection within a bridge circuit, which is powered by a sinusoidal source of given amplitude and known frequency. Precautionary measures are taken for improved linearity and minimal interference of the power supply on experimental data obtained as a result of measurement. The experimental data shows good consistency with the theoretical details and derivations

Efficacy and effectiveness of dihydroartemisinin-piperaquine versus artesunate-mefloquine in falciparum malaria: an open-label randomised comparison.

BACKGROUND: Artemisinin-based combinations are judged the best treatments for multidrug-resistant Plasmodium falciparum malaria. Artesunate-mefloquine is widely recommended in southeast Asia, but its high cost and tolerability profile remain obstacles to widespread deployment. To assess whether dihydroartemisinin-piperaquine is a suitable alternative to artesunate-mefloquine, we compared the safety, tolerability, efficacy, and effectiveness of the two regimens for the treatment of uncomplicated falciparum in western Myanmar (Burma). METHODS: We did an open randomised comparison of 3-day regimens of artesunate-mefloquine (12/25 mg/kg) versus dihydroartemisinin-piperaquine (6.3/50 mg/kg) for the treatment of children aged 1 year or older and in adults with uncomplicated falciparum malaria in Rakhine State, western Myanmar. Within each group, patients were randomly assigned supervised or non-supervised treatment. The primary endpoint was the PCR-confirmed parasitological failure rate by day 42. Failure rates at day 42 were estimated by Kaplan-Meier survival analysis. This study is registered as an International Standard Randomised Controlled Trial, number ISRCTN27914471. FINDINGS: Of 652 patients enrolled, 327 were assigned dihydroartemisinin-piperaquine (156 supervised and 171 not supervised), and 325 artesunate-mefloquine (162 and 163, respectively). 16 patients were lost to follow-up, and one patient died 22 days after receiving dihydroartemisinin-piperaquine. Recrudescent parasitaemias were confirmed in only two patients; the day 42 failure rate was 0.6% (95% CI 0.2-2.5) for dihydroartemisinin-piperaquine and 0 (0-1.2) for artesunate-mefloquine. Whole-blood piperaquine concentrations at day 7 were similar for patients with observed and non-observed dihydroartemisinin-piperaquine treatment. Gametocytaemia developed more frequently in patients who had received dihydroartemisinin-piperaquine than in those on artesunate-mefloquine: day 7, 18 (10%) of 188 versus five (2%) of 218; relative risk 4.2 (1.6-11.0) p=0.011. INTERPRETATION: Dihydroartemisinin-piperaquine is a highly efficacious and inexpensive treatment of multidrug-resistant falciparum malaria and is well tolerated by all age groups. The effectiveness of the unsupervised treatment, as in the usual context of use, equalled its supervised efficacy, indicating good adherence without supervision. Dihydroartemisinin-piperaquine is a good alternative to artesunate-mefloquine

Geographic Resource Allocation Based on Cost Effectiveness: An Application to Malaria Policy.

Healthcare services are often provided to a country as a whole, though in many cases the available resources can be more effectively targeted to specific geographically defined populations. In the case of malaria, risk is highly geographically heterogeneous, and many interventions, such as insecticide-treated bed nets and malaria community health workers, can be targeted to populations in a way that maximises impact for the resources available. This paper describes a framework for geographically targeted budget allocation based on the principles of cost-effectiveness analysis and applied to priority setting in malaria control and elimination. The approach can be used with any underlying model able to estimate intervention costs and effects given relevant local data. Efficient geographic targeting of core malaria interventions could significantly increase the impact of the resources available, accelerating progress towards elimination. These methods may also be applicable to priority setting in other disease areas

Sound absorption performance of sustainable foam materials: Application of analytical and numerical tools for the optimization of forecasting models

Traditional models used to predict acoustic properties of poroelastic materials are usually applied to fibrous layers or polyurethane foams. However, for new materials like complex cellular foams these procedures may not be applied due to the different cell microstructure. To this aim, the sound absorbing properties of novel sustainable foam materials are investigated as a function of the nature and loading of waste powders and their effects on the microstructure and the acoustic properties. The foams are prepared from naturally occurring alginates that are in situ polymerized. The morphology and the acoustic properties of the foam-cells appear linked to the particle size distribution of the starting powder. Determination of the parameters of Johnson\u2013Champoux\u2013Allard acoustic model (tortuosity, viscous characteristic length, thermal characteristic length, porosity and flow resistivity) was performed using five different forecasting methods, including traditional analytical model for fibrous materials as well as inverse procedure. A new procedure for tortuosity computation of foam is proposed and validated. Transfer Matrix Method calculation of the absorption coefficient was performed and compared with the experimental data, in order to assess the validity of the model. Indirect method technique is demonstrated to be dependent on experimental measurement of thermal characteristic length