An agile information-architecture-driven approach for the development of user-centered interactive software

This is the author's version of the work. It is posted here for your personal use. Not for redistribution. The definitive Version of Record was published in Interacción '15: Proceedings of the XVI International Conference on Human Computer Interaction, http://dx.doi.org/10.1145/2829875.2829919.For the most part, Information Architecture processes include sets of activities and techniques to be carried out by the development team to create interactive applications effectively, involving usability concerns at every development step. In fact, plenty of process models have already been proposed to bridge the gap between User-Centered Development and Information Architecture, empowering the development team to build usable applications successfully. However, the combination of User- Centered Development and Information Architecture paradigms sometimes results in cumbersome process models containing lots of phases and activities to be considered, which increases the cycle time to have partial and validated software increments readily. As less effort has been devoted to speed up the usable Information Architecture development, the aim of this paper is to address such problem. To do so, we present Scrum-UIA, an agile and usable development process driven by the Information Architecture. This process is intended to develop web applications by splitting up responsibilities and tasks, and decreasing the time to perform technical activities, in order to readily obtain usable software increments.This work has been supported by the funding projects «eMadrid», granted by the Madrid Research Council (project code S2013/ICE-2715) and «Flexor», granted by the Spanish Government (project code TIN2014-52129-R)

Enhanced attention capture by emotional stimuli in mild traumatic brain injury

Mild traumatic brain injury (mTBI) may be associated with compromised executive functioning and altered emotional reactivity. Despite frequent affective and cognitive symptoms in mTBI, objective evidence for brain dysfunction is often lacking. Previously we have reported compromised performance in symptomatic mTBI patients in an executive reaction time (RT) test, a computer-based RT test engaging several executive functions simultaneously. Here, we investigated the cognitive control processes in mTBI in context of threat-related stimuli. We used behavioral measures and event-related potentials (ERP) to investigate attentional capture by task-relevant and task-irrelevant emotional stimuli during a Go-NoGo task requiring cognitive control. We also assessed subjective cognitive, somatic, and emotional symptoms with questionnaires. Twenty-seven subjects with previous mTBI and 17 controls with previous ankle injury participated in the study over 9 months post-injury. Electroencephalogram (EEG) was recorded while patients performed a modified executive RT-test. N2-P3 ERP component was used as a general measure of allocated attentional and executive processing resources. Although at the time of the testing, the mTBI and the control groups did not differ in symptom endorsement, mTBI patients reported having had more emotional symptoms overall since the injury than controls. The overall RT-test performance levels did not differ between groups. However, when threat-related emotional stimuli were used as Go-signals, the mTBI group was faster than the control group. In comparison to neutral stimuli, threat-related stimuli were associated with increased N2-P3 amplitude in all conditions. This threat-related enhancement of the N2-P3 complex was greater in mTBI patients than in controls in response to Go signals and NoGo signals, independent of relevance. We conclude that mTBI may be associated with enhanced attentional and executive resource allocation to threat-related stimuli. Along with behavioral evidence for enhanced attention allocation to threat stimuli, increased brain responses to threat were observed in mTBI. Enhanced attention capture by threat-related emotional stimuli may reflect inefficient top-down control of bottom-up influences of emotion, and might contribute to affective symptoms in mTBI.Fil: Exposito, Veronica. Tampere University Hospital; Finlandia. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Kuusinen, Venla. Tampere University Hospital; FinlandiaFil: Brause, Maarja. Tampere University Hospital; FinlandiaFil: Peräkylä, Jari. Tampere University Hospital; FinlandiaFil: Polvivaara, Markus. Tampere University Hospital; FinlandiaFil: Dos Santos Ribeiro, Rodolfo. Tampere University Hospital; FinlandiaFil: Öhman, Juha. Tampere University Hospital; FinlandiaFil: Hartikainen, Kaisa M.. Tampere University Hospital; Finlandi

Emotional Modulation of Frontal Alpha Asymmetry - a Novel Biomarker of Mild Traumatic Brain Injury

Objective findings of brain injury or dysfunction are typically lacking in mild traumatic brain injury (MTBI) despite prolonged post-concussion symptoms in some patients. Thus, there is a need for objective biomarkers of MTBI that reflect altered brain physiology underlying subjective symptoms. We have previously reported increased attention to threat-related stimuli in subjects with MTBI, suggesting a physiological vulnerability to depression. Vulnerability to depression has been linked with relatively greater activity of the right than left frontal cortex reflected in inverse pattern in frontal alpha with greater power on the left than right. We investigated whether patients with previous MTBI show this pattern of frontal activity reflected in more negative frontal alpha asymmetry (FAA) scores. Furthermore, in search for potential biomarkers of MTBI, we created a novel index, emotional modulation of FAA (eFAA) and investigated whether it correlates with subjective symptoms. EEG was recorded while subjects with previous MTBI and controls performed a computer-based reaction time task integrating different cognitive executive functions and containing either threat-related or emotionally neutral visual stimuli. Post-concussion symptoms and depression were assessed using the Rivermead Post-Concussion Symptoms Questionnaire (RPQ) and Beck's depression inventory (BDI). Task-induced FAA was assessed and eFAA calculated by subtracting FAA in the context of neutral stimuli from FAA in the context of emotional stimuli. The MTBI group showed FAA scores reflecting relatively greater right-sided frontal activity compared to healthy controls. eFAA differentiated the symptomatic MTBI from non-symptomatic MTBI group and from healthy controls. eFAA also correlated with RPQ and BDI scores. In conclusion, FAA pattern previously linked with vulnerability to depression, was observed in patients with previous MTBI. Furthermore, eFAA has potential as a biomarker of altered affective brain functions in MTBI

An overview of regulatory issues that affect the development of new waste treatment technologies

The development of new and innovative waste treatment technologies can significantly benefit the U.S. Department of Energy's (DOE) environmental restoration and waste management program. New technologies are expected to facilitate faster, better, cheaper, and safer remediation of existing waste problems. To encourage and direct the development of new waste treatment and management technologies, DOE established a research, development, demonstration, testing, and evaluation (RDDT E) program. The RDDT E program is managed by DOE's Office of Technology Development. The development, acceptance, and application of new technologies involves more than simply technical problems. If the best new technologies are to be applied in the fastest and most cost-effective manner possible, DOE must consider regulatory factors early and often in the technology development process. This report presents a number of regulatory issues that are relevant to any program intended to encourage the development of new waste treatment and management technologies. The report was prepared by Pacific Northwest Laboratory. 38 refs., 6 figs., 2 tabs

The Biochemistry, Ultrastructure, and Subunit Assembly Mechanism of AMPA Receptors

The AMPA-type ionotropic glutamate receptors (AMPA-Rs) are tetrameric ligand-gated ion channels that play crucial roles in synaptic transmission and plasticity. Our knowledge about the ultrastructure and subunit assembly mechanisms of intact AMPA-Rs was very limited. However, the new studies using single particle EM and X-ray crystallography are revealing important insights. For example, the tetrameric crystal structure of the GluA2cryst construct provided the atomic view of the intact receptor. In addition, the single particle EM structures of the subunit assembly intermediates revealed the conformational requirement for the dimer-to-tetramer transition during the maturation of AMPA-Rs. These new data in the field provide new models and interpretations. In the brain, the native AMPA-R complexes contain auxiliary subunits that influence subunit assembly, gating, and trafficking of the AMPA-Rs. Understanding the mechanisms of the auxiliary subunits will become increasingly important to precisely describe the function of AMPA-Rs in the brain. The AMPA-R proteomics studies continuously reveal a previously unexpected degree of molecular heterogeneity of the complex. Because the AMPA-Rs are important drug targets for treating various neurological and psychiatric diseases, it is likely that these new native complexes will require detailed mechanistic analysis in the future. The current ultrastructural data on the receptors and the receptor-expressing stable cell lines that were developed during the course of these studies are useful resources for high throughput drug screening and further drug designing. Moreover, we are getting closer to understanding the precise mechanisms of AMPA-R-mediated synaptic plasticity