UNDERSTANDING THE WEATHER- AND SOIL-RELATED VARIABILITY IN AGRICULTURAL WATER FOOTPRINTS: CASE STUDY OF MAIZE AND SOYBEANS GROWN IN THE ST. JOSEPH WATERSHED

Introduced in 2002, the water footprint is a valuable tool for understanding the consumption of freshwater resources. The traditional approach to quantifying the water footprint is to sum the green, blue, and gray water footprint components. The green water footprint is the volume of water that comes from precipitation, is stored in the soil, and used by vegetation. The blue water footprint is the volume of surface or ground water that is withdrawn and applied to cultivated lands via irrigation. These components are based on the evapotranspiration of green and blue water resources, respectively. The gray water footprint is the volume of water that is needed to dilute the resultant pollutants to ensure compliance with water quality standards in natural water bodies. Though applicable to many products and at a range of scales, the water footprint methodology is most commonly applied to agricultural products. This is because of the large volumes of water that products from this industry require. For example, in the U.S., maize and soybeans require 190 x 109 and 120 x 109 m3 in total water per year. Due to the large demands of water, applying the water footprint to an area with intensive agriculture is beneficial to effective resource management, even in areas with abundant water resources such as the Great Lakes Basin, which contains 21% of the world’s freshwater resources. Thus, the St. Joseph watershed, which is located in this area, will be investigated for how maize and soybean produced affect the freshwater resources. Because of the lack of insight gained from the traditional water footprint regarding the effects that water depletion has on local landscapes, a new approach is proposed, called the relative water footprint. Using this approach, it is shown that relative to a natural landscape of woody vegetation and deciduous trees, the agricultural water demands of the St. Joseph watershed are greatly reduced, at least in terms of the green water footprint. However, the blue and gray water footprints for maize and soybeans may still be significant and highly variable, with blue water footprints dependent on rainfall patterns, soil types, and irrigation scheduling, and gray water footprints dependent on fertilizer application rates

Freshmen Who Plan to Transfer (Analysis)

On the 2009 WELS baseline survey of incoming fall 2009 freshmen, thirteen percent indicate some likelihood of transferring prior to graduation. Western administrators are interested in the retention rate of these students, as well as demographic and educational history characteristics. This is a brief exploratory analysis of these questions

On Hecke theory for Hermitian modular forms

In this paper we outline the Hecke theory for Hermitian modular forms in the sense of Hel Braun for arbitrary class number of the attached imaginary-quadratic number field. The Hecke algebra turns out to be commutative. Its inert part has a structure analogous to the case of the Siegel modular group and coincides with the tensor product of its $p$-components for inert primes $p$. This leads to a characterization of the associated Siegel-Eisenstein series. The proof also involves Hecke theory for particular congruence subgroups

Reactors for microbial electrobiotechnology

From the first electromicrobial experiment to a sophisticated microbial electrochemical process - it all takes place in a reactor. Whereas the reactor design and materials used strongly influence the obtained results, there are no common platforms for MES reactors. This is a critical convention gap, as cross-comparison and benchmarking among MES as well as MES vs. conventional biotechnological processes is needed. Only knowledge driven engineering of MES reactors will pave the way to application and commercialization. In this chapter we first assess the requirements on reactors to be used for bioelectrochemical systems as well as potential losses caused by the reactor design. Subsequently, we compile the main types and designs of reactors used for MES so far, starting from simple H-cells to stirred tank reactors. We conclude with a discussion on the weaknesses and strengths of the existing types of reactors for bioelectrochemical systems that are scored on design criteria and draw conclusions for the future engineering of MES reactors. [GRAPHICS]

Evaluation of pharmaceutical concerns in Germany: frequency and potential reasons.

BACKGROUND: Generic substitution can have unintended consequences. In Germany, brand name to generic or generic to generic switching is mainly driven by rebate contracts. Frequent switching may raise concerns about bio- and therapeutic equivalence. Expected patient confusion may result in compromised medication adherence or new onset of other drug-related problems. Since 2008, pharmacists are allowed to deviate from rebate contracts by denying substitution due to pharmaceutical concerns on an individual basis. OBJECTIVES: To explore the frequency of documented pharmaceutical concerns in Germany between July 2011 and December 2013 and to identify the medicines most frequently related to pharmaceutical concerns in 2013. METHODS: We analyzed documented pharmaceutical concerns in all prescribed drugs at the expense of any statutory health insurance company requiring pharmacies' generic substitution according to rebate contracts. RESULTS: Since July 2011, the frequency of documented pharmaceutical concerns in relation to prescribed drug products with rebate contracts requiring substitution increased consistently and doubled between July 2011 and July 2013. Overall in 2013, the trend of the two previous years continued and reached approximately 1.5%. The most affected drugs/drug classes were thyroid hormones (in particular combinations with iodide; 15.9%) followed by ondansetron (12.5%), and levothyroxine (11.3%). For all drugs/drug classes under investigation, product-, patient- or disease-related aspects could be identified which are potential reasons to deny substitution and to document pharmaceutical concerns. CONCLUSIONS: Although there is no electronic recording of the specific reasons for pharmaceutical concerns in claims data, our analyses support the assumption that pharmacists make use of this instrument based on individual clinical decisions and as required by contract. Pharmaceutical concerns are, therefore, an important instrument for pharmacies to refuse generic substitution. They are considered to prevent compromised medication safety and to assure pharmacotherapy effectiveness in a generic substitution environment driven by low drug prizes above all

Transgenic analysis of the atrialnatriuretic factor (ANF) promoter: Nkx2-5 and GATA-4 binding sites are required for atrial specific expression of ANF

AbstractThe atrial natriuretic factor (ANF) gene is initially expressed throughout the myocardial layer of the heart, but during subsequent development, expression becomes limited to the atrial chambers. Mouse knockout and mammalian cell culture studies have shown that the ANF gene is regulated by combinatorial interactions between Nkx2-5, GATA-4, Tbx5, and SRF; however, the molecular mechanisms leading to chamber-specific expression are currently unknown. We have isolated the Xenopus ANF promoter in order to examine the temporal and spatial regulation of the ANF gene in vivo using transgenic embryos. The mammalian and Xenopus ANF promoters show remarkable sequence similarity, including an Nkx2-5 binding site (NKE), two GATA sites, a T-box binding site (TBE), and two SRF binding sites (SREs). Our transgenic studies show that mutation of either SRE, the TBE or the distal GATA element, strongly reduces expression from the ANF promoter. However, mutations of the NKE, the proximal GATA, or both elements together, result in relatively minor reductions in transgene expression within the myocardium. Surprisingly, mutation of these elements results in ectopic ANF promoter activity in the kidneys, facial muscles, and aortic arch artery-associated muscles, and causes persistent expression in the ventricle and outflow tract of the heart. We propose that the NKE and proximal GATA elements serve as crucial binding sites for assembly of a repressor complex that is required for atrial-specific expression of the ANF gene

Nucleon electromagnetic form factors from lattice QCD using a nearly physical pion mass

We present lattice QCD calculations of nucleon electromagnetic form factors using pion masses $m_\pi$ = 149, 202, and 254 MeV and an action with clover-improved Wilson quarks coupled to smeared gauge fields, as used by the Budapest-Marseille-Wuppertal collaboration. Particular attention is given to removal of the effects of excited state contamination by calculation at three source-sink separations and use of the summation and generalized pencil-of-function methods. The combination of calculation at the nearly physical mass $m_\pi$ = 149 MeV in a large spatial volume ($m_\pi L_s$ = 4.2) and removal of excited state effects yields agreement with experiment for the electric and magnetic form factors $G_E(Q^2)$ and $G_M(Q^2)$ up to $Q^2$ = 0.5 GeV$^2$.Comment: v2: published version; 30 pages, 25 figures, 6 table