404 research outputs found
Optimized biomimetic hair sensor arrays for sensing oscillating air flows
Artificial hair sensor arrays are bio-inspired from flow-sensitive filiform hairs of the crickets, one of nature’s best in sensing small air flows. The presented hair sensor arrays aim to realize higher sensitivities compared to our previous sensor arrays by means of model-based design optimizations and fabricated with advanced MEMS technologies. The artificial hair-sensor arrays display a clear figure-of-eight response and show remarkable sensitivities to oscillating air flows down to 0.85 mm/s surpassing noise levels even at 1 kHz operational bandwidths
Common variable immunodeficiency, impaired neurological development and reduced numbers of T regulatory cells in a 10-year-old boy with a STAT1 gain-of-function mutation
Recently, gain-of-function (GOF) mutations in the gene encoding signal transducer and activator of transcription 1 (STAT1) have been associated with chronic mucocutaneous candidiasis (CMC). This case report describes a 10-year-old boy presenting with signs of common variable immunodeficiency (CVID), failure to thrive, impaired neurological development, and a history of recurrent mucocutaneous Candida infections. Sequencing of the STAT1 gene identified a heterozygous missense mutation in exon 7 encoding the STAT1 coiled-coil domain (c.514T > C, p.Phe172Leu). In addition to hypogammaglobulinemia with B-cell deficiency, and a low percentage of Th17 cells, immunological analysis of the patient revealed a marked depletion of forkhead-box P3+-expressing regulatory T cells (Tregs). In vitro stimulation of T cells from the patient with interferon-α (IFNα) and/or IFNɣ resulted in a significantly increased expression of STAT1-regulated target genes such as MIG1, IRF1, MX1, MCP1/CCL2, IFI-56K, and CXCL10 as compared to IFN-treated cells from a healthy control, while no IFNα/ɣ-mediated up-regulation of the FOXP3 gene was found. These data demonstrate that the STAT1 GOF mutation F172L, which results in impaired stability of the antiparallel STAT1 dimer conformation, is associated with inhibited Treg cell development and neurological symptoms
Earth system modeling with endogenous and dynamic human societies: the copan:CORE open World-Earth modeling framework
Analysis of Earth system dynamics in the Anthropocene requires explicitly taking into account the increasing magnitude of processes operating in human societies, their cultures, economies and technosphere and their growing feedback entanglement with those in the physical, chemical and biological systems of the planet. However, current state-of-the-art Earth system models do not represent dynamic human societies and their feedback interactions with the biogeophysical Earth system and macroeconomic integrated assessment models typically do so only with limited scope. This paper (i) proposes design principles for constructing world-Earth models (WEMs) for Earth system analysis of the Anthropocene, i.e., models of social (world)-ecological (Earth) coevolution on up to planetary scales, and (ii) presents the copan:CORE open simulation modeling framework for developing, composing and analyzing such WEMs based on the proposed principles. The framework provides a modular structure to flexibly construct and study WEMs. These can contain biophysical (e.g., carbon cycle dynamics), socio-metabolic or economic (e.g., economic growth or energy system changes), and sociocultural processes (e.g., voting on climate policies or changing social norms) and their feedback interactions, and they are based on elementary entity types, e.g., grid cells and social systems. Thereby, copan:CORE enables the epistemic flexibility needed for contributions towards Earth system analysis of the Anthropocene given the large diversity of competing theories and methodologies used for describing socio-metabolic or economic and sociocultural processes in the Earth system by various fields and schools of thought. To illustrate the capabilities of the framework, we present an exemplary and highly stylized WEM implemented in copan:CORE that illustrates how endogenizing sociocultural processes and feedbacks such as voting on climate policies based on socially learned environmental awareness could fundamentally change macroscopic model outcomes
The Charge Form Factor of the Neutron at Low Momentum Transfer from the Reaction
We report new measurements of the neutron charge form factor at low momentum
transfer using quasielastic electrodisintegration of the deuteron.
Longitudinally polarized electrons at an energy of 850 MeV were scattered from
an isotopically pure, highly polarized deuterium gas target. The scattered
electrons and coincident neutrons were measured by the Bates Large Acceptance
Spectrometer Toroid (BLAST) detector. The neutron form factor ratio
was extracted from the beam-target vector asymmetry
at four-momentum transfers , 0.20, 0.29 and 0.42
(GeV/c).Comment: 5 pages, 3 figures, submitted to Phys. Rev. Let
Earth system modeling with endogenous and dynamic human societies: the copan:CORE open World-Earth modeling framework
Analysis of Earth system dynamics in the Anthropocene requires to explicitly
take into account the increasing magnitude of processes operating in human
societies, their cultures, economies and technosphere and their growing
feedback entanglement with those in the physical, chemical and biological
systems of the planet. However, current state-of-the-art Earth System Models do
not represent dynamic human societies and their feedback interactions with the
biogeophysical Earth system and macroeconomic Integrated Assessment Models
typically do so only with limited scope. This paper (i) proposes design
principles for constructing World-Earth Models (WEM) for Earth system analysis
of the Anthropocene, i.e., models of social (World) - ecological (Earth)
co-evolution on up to planetary scales, and (ii) presents the copan:CORE open
simulation modeling framework for developing, composing and analyzing such WEMs
based on the proposed principles. The framework provides a modular structure to
flexibly construct and study WEMs. These can contain biophysical (e.g. carbon
cycle dynamics), socio-metabolic/economic (e.g. economic growth) and
socio-cultural processes (e.g. voting on climate policies or changing social
norms) and their feedback interactions, and are based on elementary entity
types, e.g., grid cells and social systems. Thereby, copan:CORE enables the
epistemic flexibility needed for contributions towards Earth system analysis of
the Anthropocene given the large diversity of competing theories and
methodologies used for describing socio-metabolic/economic and socio-cultural
processes in the Earth system by various fields and schools of thought. To
illustrate the capabilities of the framework, we present an exemplary and
highly stylized WEM implemented in copan:CORE that illustrates how endogenizing
socio-cultural processes and feedbacks could fundamentally change macroscopic
model outcomes
Measurement of the proton electric to magnetic form factor ratio from \vec ^1H(\vec e, e'p)
We report the first precision measurement of the proton electric to magnetic
form factor ratio from spin-dependent elastic scattering of longitudinally
polarized electrons from a polarized hydrogen internal gas target. The
measurement was performed at the MIT-Bates South Hall Ring over a range of
four-momentum transfer squared from 0.15 to 0.65 (GeV/c).
Significantly improved results on the proton electric and magnetic form factors
are obtained in combination with previous cross-section data on elastic
electron-proton scattering in the same region.Comment: 4 pages, 2 figures, submitted to PR
Spin-Momentum Correlations in Quasi-Elastic Electron Scattering from Deuterium
We report on a measurement of spin-momentum correlations in quasi-elastic
scattering of longitudinally polarized electrons with an energy of 720 MeV from
vector-polarized deuterium. The spin correlation parameter was
measured for the reaction for missing
momenta up to 350 MeV/ at a four-momentum transfer squared of 0.21
(GeV/c). The data give detailed information about the spin structure of the
deuteron, and are in good agreement with the predictions of microscopic
calculations based on realistic nucleon-nucleon potentials and including
various spin-dependent reaction mechanism effects. The experiment demonstrates
in a most direct manner the effects of the D-state in the deuteron ground-state
wave function and shows the importance of isobar configurations for this
reaction.Comment: 4 pages, 3 figures, submitted to Phys. Rev. Lett. for publicatio
A gas analyzer for the internal polarized target of the HERMES experiment
A gas analyzer has been developed for the internal polarized target of the HERMES experiment at DESY in order to determine the relative amount of atomic and molecular hydrogen or deuterium in a gas sample. The precise quantitative knowledge of this ratio is crucial because the nucleons in atoms and molecules contribute differently to the average nuclear polarization of the target gas. A new calibration technique used to derive the relative sensitivity to atoms and molecules is presented. As an example, it is shown how the gas analyzer is used within the HERMES environment to divide the molecules in the gas sample into an unpolarized and a potentially polarized fraction
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